Protein Alignment CG14516 and Lta4h

DIOPT Version :9

• Sequence 1: NP_651674.3
• Gene: CG14516 / 43444
• FlyBaseID: FBgn0039640
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_032543.2
• Gene: Lta4h / 16993
• MGIID: 96836
• Length: 611
• Species: Mus musculus
• Alignment Length: 570
• Identity: 125/570 - (21%)
• Similarity: 212/570 - (37%)
• Gaps: 132/570 - (23%)

  Fly    76 TCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNITIEPQLSGNFTFAGS 140
            ||:...|.|    ||.:.|| .|:...|...:                            |..|:
Mouse     7 TCSLASPAS----VCRTQHL-HLRCSVDFARR----------------------------TLTGT 38

  Fly   141 VQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFF-----VI 200
            ..:.::..|:      :...|.:...|.::.:|..||:        ..:|.:|..|.:     .|
Mouse    39 AALTVQSQEE------NLRSLTLDTKDLTIEKVVINGQ--------EVKYTLGESQGYKGSPMEI 89

  Fly   201 ELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEVHNETRWVAS------------TQFQATDA 253
            .|...|.|:.|.|:.:.|:             :....:..:|:..            :|.||...
Mouse    90 SLPIALSKNQEIVIEISFE-------------TSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHC 141

  Fly   254 RRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYLVAYA 318
            |...||.|.|::|..:|..::.|:.:..:.:............||.....|.:.:|:..||:|..
Mouse   142 RAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALV 206

  Fly   319 ISDFTHISSG-NFAVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIAL-PEFQAGA 381
            :........| ...||:..:.::.:....|....:|...:| ....:...:.|::.| |.|..|.
Mouse   207 VGALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAED-LGGPYVWGQYDLLVLPPSFPYGG 270

  Fly   382 MENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYME 446
            ||| ..:||....:|       |.:|. :::|:.||::|.|.|||||...|...|||||...|:|
Mouse   271 MEN-PCLTFVTPTLL-------AGDKS-LSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLE 326

  Fly   447 YLTADAVAPE----------WKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEISE--IFDR 499
            ......:..|          |.:|..          .:.....||..:..|.:.:::..  .:..
Mouse   327 RHICGRLFGEKFRHFHALGGWGELQN----------TIKTFGESHPFTKLVVDLKDVDPDVAYSS 381

  Fly   500 ISYAKGSTIIRMMAHFLTNP-IFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVK 563
            |.|.||..::..:...|..| :|...|..|:::.:|.|.|.||...||....|     |....:.
Mouse   382 IPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDDWKSFLYSHFK-----DKVDLLN 441

  Fly   564 EI-MDTWTLQTGYPVVKVSRHPNSDV------IRLEQVRFVYTNTTREDE 606
            :: .:||....|.|.||    ||.||      |.|.| |:|   |.:|::
Mouse   442 QVDWNTWLYAPGLPPVK----PNYDVTLTNACIALSQ-RWV---TAKEED 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	82/422 (19%)
		M1_APN_2	121..576	CDD:189008	101/487 (21%)
		ERAP1_C	652..974	CDD:288671
Lta4h	NP_032543.2	leuko_A4_hydro	6..608	CDD:274120	125/570 (22%)
		M1_LTA4H	6..450	CDD:189006	110/527 (21%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	135..137		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	267..272		1/4 (25%)
		Leuk-A4-hydro_C	468..607	CDD:286244	7/20 (35%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	564..566

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810