DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14516 and Anpep

DIOPT Version :9

Sequence 1:NP_651674.3 Gene:CG14516 / 43444 FlyBaseID:FBgn0039640 Length:999 Species:Drosophila melanogaster
Sequence 2:NP_032512.2 Gene:Anpep / 16790 MGIID:5000466 Length:966 Species:Mus musculus


Alignment Length:986 Identity:349/986 - (35%)
Similarity:529/986 - (53%) Gaps:77/986 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 ILLASFFICTLLAVGFIVY---------NFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYD 109
            |||....:||::|:. :||         |.||...| |.|......|:            ||..|
Mouse    16 ILLGVAAVCTIIALS-VVYAQEKNRNAENSATAPTL-PGSTSATTATT------------TPAVD 66

  Fly   110 -----RDVRLPHSIRPLKYNITIEPQLSGN----FTFAGSVQIRIRVLEDCYNITMHAEELNISR 165
                 ...|||.::.|..|.:.:.|.|:.|    :.|.|:..:|....:....|.:|:::||.:.
Mouse    67 ESKPWNQYRLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVIIIHSKKLNYTL 131

  Fly   166 SDASVHRV---QNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQ 227
            .  ..|||   ..:|.|..:   |.|..||...::.|:.|...|::..:|.:..:|.|.:.|.|.
Mouse   132 K--GNHRVVLRTLDGTPAPN---IDKTELVERTEYLVVHLQGSLVEGRQYEMDSQFQGELADDLA 191

  Fly   228 GFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSND 292
            |||||.|...:..:.||:||.||.|||::||||||||:||.|.:.:..|.|:..:|||....|..
Mouse   192 GFYRSEYMEGDVKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNLIALSNMLPKESKP 256

  Fly   293 HATMPSYVWDHFAESLPMSTYLVAYAISDFTHISSGN-----FAVWARADAIK--SAEYALSVGP 350
            :...||.....|..:..|||||:||.:|:|.:|||.:     ..:|||..||.  ..:|||:|..
Mouse   257 YPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQIGIWARPSAIDEGQGDYALNVTG 321

  Fly   351 RILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVG 415
            .||.|....:|.::||||.|.||||:|.|||||||||:|:||:::::|...::.:||:||.:|:.
Mouse   322 PILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSISNKERVVTVIA 386

  Fly   416 HELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTS 480
            |||||||||||||.:||:|:|||||||||:|||.||...|.|...|..|:|::..|..:|||::|
Mouse   387 HELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASS 451

  Fly   481 HKIS---HEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDL 542
            |.:|   .|:..|.:|.|:||.|:|:||:::|||::.|||..:|::|||.||....|::....||
Mouse   452 HPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTVYLDL 516

  Fly   543 WHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVY---TNTTRE 604
            |..|.........:....:|:.|||.|.||.|:||:.|    |::...:.|..|:.   :|.||.
Mouse   517 WEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITV----NTNTGEISQKHFLLDSKSNVTRP 577

  Fly   605 DE-SLLWYIPITFTTDSELNFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDL 668
            .| :.:|..||.|....:      ....|:...| .:....:.|..:|.:.|:..||||.||||.
Mouse   578 SEFNYIWIAPIPFLKSGQ------EDHYWLDVEK-NQSAKFQTSSNEWILLNINVTGYYLVNYDE 635

  Fly   669 ENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAI 733
            .||..:...|.  .:...|...||||:|.|..|||....:....|::.|.:|..|..::||:||:
Mouse   636 NNWKKLQNQLQ--TDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPWQAAL 698

  Fly   734 SNFIFIDSMFVNSGDYDLLKNYLLKQLKKV--YDQVGFKDSQDESEDILVKLKRADILSMACHLG 796
            |:..:...||..|..|..:|.||.||:..:  |.|....:..:....::.:....:.:|.||..|
Mouse   699 SSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPPTLMEQYNEINAISTACSSG 763

  Fly   797 HQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKD 861
            .:||.......:..||:.||   ||.|.||||..|||:||.:|.|.||:||:|:|....:..|.|
Mouse   764 LKECRDLVVELYSQWMKNPN---NNTIHPNLRSTVYCNAIAFGGEEEWNFAWEQFRNATLVNEAD 825

  Fly   862 LLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYM 926
            .|.:||.|||:.|:|.|:|...::..:|||||......::::.|.|..:.:||:|:||:::....
Mouse   826 KLRSALACSKDVWILNRYLSYTLNPDYIRKQDTTSTIISIASNVAGHPLVWDFVRSNWKKLFENY 890

  Fly   927 GSQMSSIHTLFKFATKGFNSKFQLGEFENFVKD----AHWDYDRPVQQIVEHIETSVDWMNKNYK 987
            |....|...|.:..|:.|:|:|:|.:.|.|..|    ......|.::|.:|....::||:.:|..
Mouse   891 GGGSFSFANLIQGVTRRFSSEFELQQLEQFKADNSATGFGTGTRALEQALEKTRANIDWVKENKD 955

  Fly   988 SIVRWL-ENEA 997
            ::.:|. ||.:
Mouse   956 AVFKWFTENSS 966

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14516NP_651674.3 Peptidase_M1 113..505 CDD:279741 170/408 (42%)
M1_APN_2 121..576 CDD:189008 193/471 (41%)
ERAP1_C 652..974 CDD:288671 109/327 (33%)
AnpepNP_032512.2 Cytosolic Ser/Thr-rich junction 33..68 11/47 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..64 8/34 (24%)
Metalloprotease 69..966 331/917 (36%)
M1_APN-Q_like 84..545 CDD:341064 190/465 (41%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P15144 351..355 3/3 (100%)
ERAP1_C 618..945 CDD:403137 111/331 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 242 1.000 Domainoid score I2219
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68163
Inparanoid 1 1.050 585 1.000 Inparanoid score I998
Isobase 1 0.950 - 0 Normalized mean entropy S2057
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 1 1.000 - - otm42431
orthoMCL 1 0.900 - - OOG6_100307
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3793
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.850

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