DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and Enpep

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_031960.1	Gene:	Enpep / 13809	MGIID:	106645	Length:	945	Species:	Mus musculus

Alignment Length:	996	Identity:	315/996 - (31%)
Similarity:	521/996 - (52%)	Gaps:	112/996 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RRYSVSLTTAILLASFFICTLLAVGFIVYNFATCAE---------------LEPDSDEDVVCTSY 93
            ::|.:......::....:...|.||..|....:|.:               ..|..|::|...|
Mouse    10 KKYCIKGKHVAIICGVVVAVGLIVGLSVGLTRSCEQDTTPAPSQPPPEASTALPPQDQNVCPDS- 73

  Fly    94 HLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHA 158
                    .|::.:: ::.|||..|.|:.|::.::..:..: .:.|.|.|.:.:.:...::.:|.
Mouse    74 --------EDESGEW-KNFRLPDFINPVHYDLEVKALMEED-RYTGIVTISVNLSKPTRDLWLHI 128

  Fly   159 EELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLK---DVEYVVHLRFDG 220
            .|..|:       ::.....|.|:.:.|.:.:....:::.||:..:.|..   |..|.:.:.|.|
Mouse   129 RETKIT-------KLPELRRPSGEQVPIRRCFEYKKQEYVVIQAAEDLAATSGDSVYRLTMEFKG 186

  Fly   221 IIEDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNM 285
            .:...|.|||:::|....:.|.:|:|..:.||||::|||||||..|:.:::.|..|:..:.:|||
Mouse   187 WLNGSLVGFYKTTYMEDGQIRSIAATDHEPTDARKSFPCFDEPNKKSTYSISIIHPKEYSALSNM 251

  Fly   286 PIVSSNDHATMPSYVWDH--FAESLPMSTYLVAYAISDFTHIS----SGN-FAVWARADAIKSAE 343
            |    .:.:.|....|..  |.:|:|||||||.:|:..||.|.    ||. ..|:.:.:..::||
Mouse   252 P----EEKSEMVDDNWKKTTFVKSVPMSTYLVCFAVHRFTAIERKSRSGKPLKVYVQPNQKETAE 312

  Fly   344 YALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQ 408
            ||.::...:..:.:|:|.:.:.|||:|.||:|:|..||||||||:|:|||.:||||.::.::|:|
Mouse   313 YAANITQAVFDYFEDYFAMEYALPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQ 377

  Fly   409 RVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQ 473
            ||||||.|||.||||||.||..||.|:||||||||:.|:|..:....:|:.|.|.::.::..|.:
Mouse   378 RVASVVAHELVHQWFGNTVTMDWWDDLWLNEGFASFFEFLGVNHAEKDWQMLSQVLLEDVFPVQE 442

  Fly   474 LDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSAT 538
            .|:|.:||.:...|..|.||:.:||.|||:||::|:||:..::|...|::|...||::..:.:|.
Mouse   443 DDSLMSSHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLKKFQFANAK 507

  Fly   539 QDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTR 603
            ..|.|..|   .::|.|     .|||:|||||.|.|||||.||...|     :.|.||:.  .::
Mouse   508 TSDFWDSL---QEASNL-----PVKEVMDTWTSQMGYPVVTVSGRQN-----ITQKRFLL--DSK 557

  Fly   604 EDES-------LLWYIPITFTTDSELNFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGY 661
            .|.|       ..|.||:.:..:.     |:|.|.:....|.....|..||...:...|....|:
Mouse   558 ADPSQPPSELGYTWNIPVRWADND-----NSRITVYNRLDKGGITLNANLSGDAFLKINPDHIGF 617

  Fly   662 YRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGH 726
            |||||:...|..|.|.|.  .|....:.|:|:..|||...|||...|:|:.|:|||.||..|...
Mouse   618 YRVNYEGGTWDWIAEALS--SNHTRFSAADRSSFIDDAFALARAQLLNYKIALNLTMYLKSEEDF 680

  Fly   727 VPWKAAISNFIFIDSMFVNSGD-YDLLKNYLLKQLKKVYDQVGFKDSQDESEDILVKLKRADILS 790
            :||:..||:..:|.|||.:..: |.:::.|...|:|.|.|.:|::|:...    :.||.||.||.
Mouse   681 LPWERVISSVSYIISMFEDDRELYPMIETYFQGQVKPVADLLGWQDTGSH----ITKLLRASILG 741

  Fly   791 MACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQ-YGTEYEWDFAFERFLKT 854
            .||.:|.:|.:..||:.|.:|::     .:..|..|||.:||...:| .|.|..|::..|::.||
Mouse   742 FACKMGDREALGNASQLFDSWLK-----GSASIPVNLRLLVYRYGMQNSGNEAAWNYTLEQYQKT 801

  Fly   855 NVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNW 919
            ::..||:.||..|...|:..||.|:|........|:.||:|.|...:|....|:.:|:::::.||
Mouse   802 SLAQEKEKLLYGLASVKDVKLLARYLEMLKDPNIIKTQDVFTVIRYISYNSYGKTMAWNWIQLNW 866

  Fly   920 QEIKT-------YMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYD------RPVQQI 971
            ..:.:       |:|    .|.|:    .:.||::.||.:.::|..    .|.      :|.:|:
Mouse   867 DYLVSRFTINDRYLG----RIVTI----AEPFNTELQLWQMQSFFA----KYPNAGAGAKPREQV 919

  Fly   972 VEHIETSVDWMNKNYKSIVRW 992
            :|.::.:::|:|.|.:||..|
Mouse   920 LETVKNNIEWLNVNRQSIREW 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	145/401 (36%)
		M1_APN_2	121..576	CDD:189008	166/464 (36%)
		ERAP1_C	652..974	CDD:288671	104/336 (31%)
Enpep	NP_031960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..77		6/42 (14%)
		Peptidase_M1	84..474	CDD:279741	145/401 (36%)
		M1_APN_2	92..537	CDD:189008	166/464 (36%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		3/3 (100%)
		ERAP1_C	608..922	CDD:288671	104/336 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.840