DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and enpep

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_002934295.1	Gene:	enpep / 100494326	XenbaseID:	XB-GENE-977050	Length:	965	Species:	Xenopus tropicalis

Alignment Length:	944	Identity:	310/944 - (32%)
Similarity:	502/944 - (53%)	Gaps:	111/944 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 HDDTPKYD------RDVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEE 160
            |:..||.|      ::.|||..|.|:.||:.:.|.:..: |:.|:|.|.:|:.:...::.:|..|
Frog    82 HEVCPKRDDSNGDWKEFRLPTYINPVHYNVELHPVMEQD-TYNGTVSIWLRLSKTSKHLWLHLRE 145

  Fly   161 ------LNISRSDASVHRVQNNGEPEGDGLRIHKQYLV-GAKQFFVIELYDKLLKDVEYVVHLRF 218
                  |.::|....: .:|...:      .|..:||| .|:|  |::......::..|.:.|:|
Frog   146 TKIIGQLTLTRGSQQI-PIQQCFQ------YIPNEYLVLEAQQ--VLDPNSPTDENDTYCLTLQF 201

  Fly   219 DGIIEDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTIS 283
            .|.::..|.||||::|:.:..|:.:|:...:.||||::|||||||..||.:|:.|........||
Frog   202 AGRLDGSLVGFYRTTYQENGVTKSIAAADHEPTDARKSFPCFDEPNKKATYTISIIHREEYDAIS 266

  Fly   284 NMPIVSS----NDHATMPSYVWDH--FAESLPMSTYLVAYAISDFTHISSGN-----FAVWARAD 337
            |||:..|    |.        |..  |.:|:|||||||.:|:..|.::...:     ..::.:..
Frog   267 NMPVQESVALGNG--------WKRTLFEKSVPMSTYLVCFAVHQFKYVERLSKRGVPLRIYVQPL 323

  Fly   338 AIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVA 402
            ...:||||.:....:..|.:::||:.:.|||:|.||:|:|..||||||||||:|||.:||||..:
Frog   324 QNATAEYAANTTKIVFDFFEEYFNMPYSLPKLDQIAIPDFGTGAMENWGLITYRETNLLYDPNES 388

  Fly   403 TANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNE 467
            ...||||||:|:.|||.||||||:||..||.|:||||||||:.||...||..|.|..|||.::::
Frog   389 ATVNKQRVAAVIAHELVHQWFGNIVTMDWWDDLWLNEGFASFFEYSGVDAAEPLWNMLDQILIDD 453

  Fly   468 LQAVFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEM 532
            |..|.:.|||.:||.|...|..|.||:.:||.|||.||::|:||:..:::...|::|...||::.
Frog   454 LLPVMRDDALLSSHPIIVTVSTPAEITSVFDAISYNKGASILRMLEDWISPENFKKGCQDYLKDY 518

  Fly   533 AYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFV 597
            .:.:|..||.|:.|   ||:||     :.|||:|||||.|.||||:.|     ..:..::|.||:
Frog   519 VFKNAKTDDFWNSL---AKASG-----KPVKEVMDTWTRQMGYPVLNV-----ESLNTVKQTRFL 570

  Fly   598 YTNTTREDE-----SLLWYIPITF-----TTDSELNFANTRPTTWMPRTKLYELENRELSLAKW- 651
            ........|     :.:|.||:||     :.|..|.:..:.|.              .|||..:
Frog   571 LDPNANALEPPSEFNYMWNIPVTFYATNNSVDYNLLYNKSIPA--------------GLSLTPFN 621

  Fly   652 -----FI-FNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSY 710
                 |: .|.:..|::||||:|..|..::. |::. |.|....|:||.||||...|||...|.|
Frog   622 DATDGFLKINTRHLGFFRVNYELSTWNQLSA-LLEA-NHETFTDADRAGLIDDAFALARAEKLDY 684

  Fly   711 ETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGD-YDLLKNYLLKQLKKVYDQVGFKDSQD 774
            ..::::|:||..|..::.|..|||:..::..|..:... |...:.||.||:|.:..:.|::|:..
Frog   685 NISLDITKYLEKETNYLTWTRAISSLAYLSDMLEDDNTIYPKFQEYLRKQVKPITQKHGWEDTGS 749

  Fly   775 ESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQY- 838
            :.:    ||.||.:|:::|.:|..:.:.||||.|::|:      ....|..|||.:||...:|.
Frog   750 DID----KLLRASVLALSCKMGDPDALNEASRLFRDWI------GGKSIPVNLRQLVYRYGMQQS 804

  Fly   839 GTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVST 903
            |.:..|::.|:::|.|::..||:.||..|..:....|:.|:|:...:...|:.||...|...:|.
Frog   805 GNQESWNYMFQQYLTTSLAQEKEKLLQGLASANNIELIDRYLKLIYNTSLIKSQDALNVIYYISV 869

  Fly   904 -TVVGQNIAFDFLRNNWQEIKTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDY--- 964
             :..|:.:|:|::|.||..:.........::..:....:..||:..||.:.|||.:    .|
Frog   870 YSQYGKQMAWDWVRINWDYLVDRYNINDRNLGRIVTRISGTFNTATQLWQMENFFE----KYPNA 930

  Fly   965 ---DRPVQQIVEHIETSVDWMNKNYKSIVRWLEN 995
               :.|.:|.:|.:..:::|:..|.:.|..||.:
Frog   931 GAGEIPRKQALETVRNNIEWVAANKEGIKSWLNS 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	158/409 (39%)
		M1_APN_2	121..576	CDD:189008	181/472 (38%)
		ERAP1_C	652..974	CDD:288671	95/331 (29%)
enpep	XP_002934295.1	M1_APN-Q_like	107..549	CDD:341064	178/467 (38%)
enpep	XP_002934295.1	ERAP1_C	627..946	CDD:378732	96/334 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920