DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and trhde.1

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_001345457.3	Gene:	trhde.1 / 100006808	ZFINID:	ZDB-GENE-170406-2	Length:	994	Species:	Danio rerio

Alignment Length:	1006	Identity:	314/1006 - (31%)
Similarity:	529/1006 - (52%)	Gaps:	88/1006 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PTTTTTFSKGGRR----YSVSLTTAILL--------ASFFICTLLAVGFIVYNFATCAELEPDSD 85
            |.||.......:|    :::|:.|.|::        .||..|...:.|.:..|.::.::.:...|
Zfish    26 PRTTEQHITVHKRLVLGFAISILTLIIVTAIAITLSVSFERCAAESSGALAANGSSNSKWKQSRD 90

  Fly    86 EDVVCTSYHLRRLKAGHDDTPKYD---RDVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRV 147
            .::            .|.|:....   |.:|||.::||..|::.:...:. ||:|:|.|.|....
Zfish    91 GNI------------SHRDSEDGQQPWRHLRLPATLRPRHYDLRLTVHME-NFSFSGEVNIEFEC 142

  Fly   148 LEDCYNITMHAEELNISR----SDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLK 208
            :.....|.:|::.|.:.:    ||:.          :...:||.:::....||.:||.|:.::..
Zfish   143 VNSTKLIVLHSDRLELDKVLVFSDSK----------KAGAMRIQRRFHYQPKQVYVIALHREMKP 197

  Fly   209 DVEYVVHLRFDGIIEDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHI 273
            ...|.:::.|...||..|.||:||||.::.|.|::|.|||..|.||:||||||||..||.|.:.:
Zfish   198 LRTYKINITFTAHIEHELLGFFRSSYMLNGERRFLAVTQFSPTHARKAFPCFDEPIYKATFRVSL 262

  Fly   274 ARPRNMTTISNMPI-VSSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTH---ISSGNFAV-- 332
            ....:..::||||: .:::|.   ..:|.:||:.:..||||.:|:|:.:||:   ::.....:
Zfish   263 KHESSYQSLSNMPVEATTSDE---DGWVTNHFSRTPRMSTYYLAWAVCNFTYKEAVADNGVLIRL 324

  Fly   333 WARADAIK--SAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAM 395
            :||.|||:  |.:|||.:..|:|.|.||:|.|.:.|||:|::|:|:....|||||||..|.|..:
Zfish   325 YARPDAIQSGSGDYALRITKRLLQFYQDYFKVKYSLPKLDLLAVPKHPYSAMENWGLSVFVEQKI 389

  Fly   396 LYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWK-Q 459
            |.||.|::.:.:..:..||.||:.|||||:||||.||.|:||.||||.|.||:.||.:.|:|. :
Zfish   390 LLDPEVSSFSYQMELTVVVVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEYIGADFLFPKWNME 454

  Fly   460 LDQFVVNELQAVFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRG 524
            ..:|:.:.|..|..||.|::||.||.:||...:|..:||.|:|.||:.:|||:|:.:...:|:|.
Zfish   455 KQRFLTDVLHEVMLLDGLASSHPISQQVFEATDIDRVFDWIAYKKGAALIRMLANVMGQTLFQRA 519

  Fly   525 LSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSD-V 588
            |:.||....|.:|.:||||:.|:...:..|   ...::.::||.||||.|||||.:|::.:.| .
Zfish   520 LNDYLMTHMYGNAARDDLWNKLSEAMQREG---KDINITQVMDRWTLQMGYPVVTISKNDSLDNS 581

  Fly   589 IRLEQVRFVY------TNTTREDESLLWYIPITFTTDSELNFANTRPTTWMP-RTKLYELENREL 646
            |.:.|..|||      .|....::|..|.||:|... ...:..:|....|:. :::.:.:.:  :
Zfish   582 ITISQEHFVYDTDAKIQNPELFNKSFQWQIPLTLAV-GNASHISTETIIWVTNKSEAHRVGH--M 643

  Fly   647 SLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYE 711
            ....|.:.|:.||||:||||||.||..:.:.||  .|...|:..|||.|||||.||||..||...
Zfish   644 VGETWLLGNINQTGYFRVNYDLHNWKLLIQQLM--SNPTIISVGNRAGLIDDVFNLARAGYLPQN 706

  Fly   712 TAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQLKKVYDQVG-------- 768
            ..:.:..||..|...:||.||......:|.:...:.|:.|..:|:|:|::..|.::|
Zfish   707 VPLQMISYLSQEPEFLPWHAASRALYQLDKLLDRTLDHSLFSDYVLRQVEPKYHKLGWPATSPDG 771

  Fly   769 -FKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVY 832
             |..|..::|::     :.:::.:||..|::.|..:|.....:|:.:    :.|.|.||:|.:||
Zfish   772 SFMHSAYQTEEL-----QREVIMLACSFGNKHCHRQAVSLISDWISS----NKNRIPPNVRDIVY 827

  Fly   833 CSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRV 897
            |:.:....|..|:|.:.:|..:....||.:||.||.||...:||.|.|...::...:..||:..|
Zfish   828 CTGVSLMDEDVWEFIWMKFHSSTAVSEKKVLLEALTCSDNIFLLNRLLNLSLTSDLVPDQDVIDV 892

  Fly   898 FAAVSTTVVGQNIAFDFLRNNWQEIKTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHW 962
            ...|:...:|:::|:.:.|..|..:.:..|..:.....|....|:..|::.:|.|.:.|:..:..
Zfish   893 IIHVARNPLGRHLAWRYFREKWDILNSRYGEALFMNSKLISGVTEFLNTEAELNELKEFILTSGG 957

  Fly   963 DYDRPVQQIVEHIETSVDWMNKNYKSIVRWL 993
            :......:.||.::.:|.|.....:...:||
Zfish   958 ESAPAFARAVEIVQANVKWHILFQEQFYQWL 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	152/404 (38%)
		M1_APN_2	121..576	CDD:189008	173/467 (37%)
		ERAP1_C	652..974	CDD:288671	95/330 (29%)
trhde.1	XP_001345457.3	Peptidase_M1	109..500	CDD:279741	152/404 (38%)
		M1_APN_2	118..568	CDD:189008	173/466 (37%)
		ERAP1_C	649..968	CDD:288671	94/329 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910