DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14516 and LOC100004744

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_001920418.2	Gene:	LOC100004744 / 100004744	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	917	Identity:	321/917 - (35%)
Similarity:	505/917 - (55%)	Gaps:	63/917 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 RDVRLPHSIRPLKYNITIEPQLS----GNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASV 170
            ::.|||.::.|..||||:.|:|.    |.:.|.|:..:..:.|.:...|.:|..:||::..|..:
Zfish    44 KEYRLPDTLFPHYYNITLWPRLQPDDHGLYVFTGNSSVVFKCLRETDIIIIHCNKLNLTSEDGYL 108

  Fly   171 HRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYE 235
            .::......|...::  |.::....|:.|::|..||.....||::..|.|.:.|.|.|.|||.|:
Zfish   109 AKLSAFSTSEVPSVK--KTWIEEMTQYLVLQLNGKLKAGELYVLYTEFVGELADDLAGLYRSEYD 171

  Fly   236 VHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHAT--MPS 298
            ...|.:.||::|...|.||:.||||||||:||.|.:.:...|....:||...:.:.|...  .|.
Zfish   172 EDGEKKIVATSQMHPTHARKTFPCFDEPAMKAVFHITLIHDRGTVALSNGMEIENVDTIVDGQPV 236

  Fly   299 YVWDHFAESLPMSTYLVAYAISDFTHISSGN---FAVWARADAIKS--AEYALSVGPRILTFLQD 358
            .| ..|..:..||:||:|..:||:|:::|.:   ..:|||..||:.  .:|||::...||.|.::
Zfish   237 TV-TTFEPTKIMSSYLLALVVSDYTNVTSADGTLIRIWARKKAIEDGHGDYALNITGPILKFFEN 300

  Fly   359 FFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWF 423
            ::||.:||.|.|.||||:|..||||||||:.:||:.:||||.|::..||:|.|:::.|||||.||
Zfish   301 YYNVPYPLSKSDQIALPDFYFGAMENWGLVMYRESNLLYDPTVSSNANKERTATIIAHELAHMWF 365

  Fly   424 GNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKIS---H 485
            |||||..||:::|||||||||:.||.||...|.|...|..::.::..||.:|||::||.:|   .
Zfish   366 GNLVTLKWWNEVWLNEGFASYVSYLGADFAEPSWNVKDLIILKDVHRVFAVDALASSHPLSSKEE 430

  Fly   486 EVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLW-HFLTVE 549
            ::..|::|.|.||.:||:||::::||::.|||.|:|.:||:.||...|..:...:||| |..|..
Zfish   431 DIIKPEQIIEQFDTVSYSKGASVLRMLSDFLTEPVFVQGLNTYLTMFADQNTVGEDLWDHLQTAV 495

  Fly   550 AKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDESLL----- 609
            .|:..:|  ..|||.|||.|.||.|:|||.|    |:...::.|:.|:.     :.||.|
Zfish   496 NKTGTVL--PLSVKVIMDRWVLQMGFPVVTV----NTTTGQVSQMHFLL-----DPESSLQRTSP 549

  Fly   610 ----WYIPITFTTDSELNFANTRPTTW-MPRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLE 669
                |.:||.:     :.....:...| :.||.:|  .:.:.:.::|.:.|:..|||||||||:.
Zfish   550 FNYEWIVPINW-----MKSKMVQSRFWLLERTAVY--NDMKTTGSEWVLLNLNITGYYRVNYDIG 607

  Fly   670 NWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAIS 734
            ||..:...|  .:|.:.|:..||||::||..||||...:....|:..|.||..|..::||::|::
Zfish   608 NWERLLNQL--AENHKVISVINRAQIVDDAFNLARAKIIPVTLALKTTTYLSEEREYMPWQSALN 670

  Fly   735 NFIFIDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQDESEDI----LVKLKRADILSMACHL 795
            |..:...||..:..|.||::|..||:..::|.  ||...::..|:    ..:..:.:.:..||..
Zfish   671 NLDYFYLMFTQTEVYRLLQSYTKKQVTPLFDY--FKTITEDWSDVPSGHTDQYNQVNAIRFACST 733

  Fly   796 GHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEK 860
            |..||....|..::.||..||   :|||.||||..||||||..|...||||.:..|  .|...|.
Zfish   734 GVDECQNLTSSWYKQWMDQPN---HNPIHPNLRSTVYCSAIATGGAEEWDFGWTMF--KNAAIEA 793

  Fly   861 DLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTY 925
            |.|:::|.|:|...||.|:|...:....|||||...|...:::...||.:|::|:||.|:.:.|.
Zfish   794 DKLMSSLACAKNQTLLKRYLGYTLDPSMIRKQDATSVIVYIASNPDGQKLAWEFVRNKWEYMFTE 858

  Fly   926 MGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKD----AHWDYDRPVQQIVEHIETSVDWMNKNY 986
            .|....:..:|....||.|:::.:|.:...|..|    ........::|.:|..:.::.|:.:|.
Zfish   859 YGVGSFNFASLISGITKTFSTEAELEQLLKFKSDNSEIGFGSATAALEQAIEKTKANIKWVAENQ 923

  Fly   987 KSIVRWL 993
            :.|..||
Zfish   924 EDITDWL 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	157/405 (39%)
		M1_APN_2	121..576	CDD:189008	184/469 (39%)
		ERAP1_C	652..974	CDD:288671	109/329 (33%)
LOC100004744	XP_001920418.2	Peptidase_M1	47..450	CDD:279741	157/405 (39%)
		M1_APN_2	57..520	CDD:189008	184/467 (39%)
		ERAP1_C	590..911	CDD:288671	109/329 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68163
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.920