DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-1 and STV1

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_013770.1	Gene:	STV1 / 855076	SGDID:	S000004658	Length:	890	Species:	Saccharomyces cerevisiae

Alignment Length:	918	Identity:	320/918 - (34%)
Similarity:	491/918 - (53%)	Gaps:	106/918 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKLRY 67
            ::|||.:|...||::..|........||::.:....|||.|:.||||.:||::||.||:||.:.:
Yeast     6 AIFRSADMTYVQLYIPLEVIREVTFLLGKMSVFMVMDLNKDLTAFQRGYVNQLRRFDEVERMVGF 70

  Fly    68 LEKEIKKDG------IPMLDTGESPEAPQPREMIDLEATFEKL---------------ENELREV 111
            |.:.::|..      |..:| .|..:..|| :|.||..|.|.|               |:..|::
Yeast    71 LNEVVEKHAAETWKYILHID-DEGNDIAQP-DMADLINTMEPLSLENVNDMVKEITDCESRARQL 133

  Fly   112 NQNAEALKRNFLELTELKHILRKTQVFFDESVPTVYKSSGAYSSSKYR---RYPQMADNQNE--- 170
            :::.::|:....:|.|.:.::.:...|.:.:.....:::......:.|   .:....|:.:|
Yeast   134 DESLDSLRSKLNDLLEQRQVIFECSKFIEVNPGIAGRATNPEIEQEERDVDEFRMTPDDISETLS 198

  Fly   171 ------DEQAQ---LLGEEGVRASQPGQNLKL---GF-----VAGVILRERLPAFERMLWRACRG 218
                  ||..|   .||.:..| :|..::|..   |:     :.|.|.|.::....|:|||..||
Yeast   199 DAFSFDDETPQDRGALGNDLTR-NQSVEDLSFLEQGYQHRYMITGSIRRTKVDILNRILWRLLRG 262

  Fly   219 NVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRVKKICEGFRATLYPCPEAPADRREMA 283
            |:..:...||.||.:  ..::|.|..||||..|:.|..:||::.:.....:.......:   |:.
Yeast   263 NLIFQNFPIEEPLLE--GKEKVEKDCFIIFTHGETLLKKVKRVIDSLNGKIVSLNTRSS---ELV 322

  Fly   284 MGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVRKIKAIYHTLNLFNLDVTQKCLIAEC 348
            ..:..:|:||..:|..|:...|..|:.....|..|....::.|.:|.|||.|..:  .:.||||.
Yeast   323 DTLNRQIDDLQRILDTTEQTLHTELLVIHDQLPVWSAMTKREKYVYTTLNKFQQE--SQGLIAEG 385

  Fly   349 WVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPTYNRTNKFTKAFQALIDAYGVASYRE 413
            |||..::..:|.:|:...|..||....:.|.:.|.:.||||:||||||:|||:::||||:|:|:|
Yeast   386 WVPSTELIHLQDSLKDYIETLGSEYSTVFNVILTNKLPPTYHRTNKFTQAFQSIVDAYGIATYKE 450

  Fly   414 MNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEKGLAAQKTDNEIWNIFFGGRYIIFLM 478
            :|....|::||||:||:||||:|||.|:.|..|:::..|:...|...| ||:::.|.|||::.||
Yeast   451 INAGLATVVTFPFMFAIMFGDMGHGFILFLMALFLVLNERKFGAMHRD-EIFDMAFTGRYVLLLM 514

  Fly   479 GVFSMYTGLIYNDIFSKSLNIF--GSHWHLSYNKSTVMENKFLQLSPKGDYEGAPYPFGMDPIWQ 541
            |.||:||||:||||||||:.||  |..|..::.|...:|.|          :...||||:|..|.
Yeast   515 GAFSVYTGLLYNDIFSKSMTIFKSGWQWPSTFRKGESIEAK----------KTGVYPFGLDFAWH 569

  Fly   542 VAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMV 606
             ...|.::|.|:||||:||:.|..||.:..:.|:.|:....:::.::..|||.|||:..:|.|:.
Yeast   570 -GTDNGLLFSNSYKMKLSILMGYAHMTYSFMFSYINYRAKNSKVDIIGNFIPGLVFMQSIFGYLS 633

  Fly   607 LLMFIKWIKFAATNDKPYSEACAPSILITFIDMVLFNTPKPPPENCETYMFMGQHFIQVLFVLVA 671
            ..:..||.|....:|||     ||.:|...|:|.|      .|...:..::.||..:||:.:|.|
Yeast   634 WAIVYKWSKDWIKDDKP-----APGLLNMLINMFL------APGTIDDQLYSGQAKLQVVLLLAA 687

  Fly   672 VGCIPVMLLAKPLLIMQARKQ------------ANV---QPIAGATSDAE---------AGGVSN 712
            :.|:|.:||.|||.:.:..|.            .|:   :.||.....||         ...|::
Yeast   688 LVCVPWLLLYKPLTLRRLNKNGGGGRPHGYQSVGNIEHEEQIAQQRHSAEGFQGMIISDVASVAD 752

  Fly   713 SGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASYLRLWALSLAHAQLAEVLWTMVLS- 776
            |.:...|||.:......::.|||.|||||:.|..:|||||||||||||||||||:.|||.|.:|
Yeast   753 SINESVGGGEQGPFNFGDVMIHQVIHTIEFCLNCISHTASYLRLWALSLAHAQLSSVLWDMTISN 817

  Fly   777 -IGLKQEG-PVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQP 839
             ...|..| |:..:.:..:||.|.:|||.|||.|||.||.||.|||||||..|||::|:|||::|
Yeast   818 AFSSKNSGSPLAVMKVVFLFAMWFVLTVCILVFMEGTSAMLHALRLHWVEAMSKFFEGEGYAYEP 882

  Fly   840 FSFDAIIE 847
            |||.||||
Yeast   883 FSFRAIIE 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	307/887 (35%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	307/886 (35%)
STV1	NP_013770.1	V_ATPase_I	32..885	CDD:396194	307/885 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344196
Domainoid	1	1.000	584	1.000	Domainoid score	I29
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	609	1.000	Inparanoid score	I127
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	1	1.010	-	-		QHG53812
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		mtm9226
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
TreeFam	1	0.960	-	-
	14	13.710