DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-1 and VPH1

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_014913.3	Gene:	VPH1 / 854444	SGDID:	S000005796	Length:	840	Species:	Saccharomyces cerevisiae

Alignment Length:	875	Identity:	336/875 - (38%)
Similarity:	462/875 - (52%)	Gaps:	92/875 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKLRY 67
            ::|||.||||.|.::..|.:......||:||||||||||..|.||||.||||:||.|.:||:.||
Yeast     7 AIFRSAEMALVQFYIPQEISRDSAYTLGQLGLVQFRDLNSKVRAFQRTFVNEIRRLDNVERQYRY 71

  Fly    68 LEKEIKKDGIPMLD---------TGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFL 123
            ....:||..|.:.:         :||....|....:.|.......||..|.::....:.::....
Yeast    72 FYSLLKKHDIKLYEGDTDKYLDGSGELYVPPSGSVIDDYVRNASYLEERLIQMEDATDQIEVQKN 136

  Fly   124 ELTELKHILRKTQVFF---DESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRAS 185
            :|.:.:.||:....||   |.:..|.|...            .|.|...|:..|.:
Yeast   137 DLEQYRFILQSGDEFFLKGDNTDSTSYMDE------------DMIDANGENIAAAI--------- 180

  Fly   186 QPGQNLKLGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQ 250
                ...:.:|.|||.|:::...|::|||..|||:|.:...||.|:.|....:..||:.||:|..
Yeast   181 ----GASVNYVTGVIARDKVATLEQILWRVLRGNLFFKTVEIEQPVYDVKTREYKHKNAFIVFSH 241

  Fly   251 GDQLKTRVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNL 315
            ||.:..|::||.|...|.||....:...|.:....|...:.||.|||..|.......|.|.||.|
Yeast   242 GDLIIKRIRKIAESLDANLYDVDSSNEGRSQQLAKVNKNLSDLYTVLKTTSTTLESELYAIAKEL 306

  Fly   316 KNWFVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRM 380
            .:||..|.:.|||:..||..|.|..:|.||||.|:|..::.|:|..|.....|.|..||.|:..:
Yeast   307 DSWFQDVTREKAIFEILNKSNYDTNRKILIAEGWIPRDELATLQARLGEMIARLGIDVPSIIQVL 371

  Fly   381 QTFENPPTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFG 445
            .|...|||::||||||..||::.|.||:|.|||:|....||:||||:||:||||:|||.:|.|..
Yeast   372 DTNHTPPTFHRTNKFTAGFQSICDCYGIAQYREINAGLPTIVTFPFMFAIMFGDMGHGFLMTLAA 436

  Fly   446 LWMIRKEKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLSYNK 510
            |.::..||.:...|. .||:::.|.|||||.||||||||||.:|||||||::.||.|.|
Yeast   437 LSLVLNEKKINKMKR-GEIFDMAFTGRYIILLMGVFSMYTGFLYNDIFSKTMTIFKSGW------ 494

  Fly   511 STVMENKFLQLSPKGDYEGA----PYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGV 571
                  |:.....||:...|    .||.|:|..|. ...|.::|.|:||||:||:.|.|||.:..
Yeast   495 ------KWPDHWKKGESITATSVGTYPIGLDWAWH-GTENALLFSNSYKMKLSILMGFIHMTYSY 552

  Fly   572 VMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITF 636
            ..|..||.||.:.|.::..|||.|:|:..:|.|:.:.:..||......:.||     ||.:|...
Yeast   553 FFSLANHLYFNSMIDIIGNFIPGLLFMQGIFGYLSVCIVYKWAVDWVKDGKP-----APGLLNML 612

  Fly   637 IDMVLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQANVQPIAGA 701
            |:|.|      .|...:..::..|..:||..:|:|:.|||.:||.|||......|:.:.:|:...
Yeast   613 INMFL------SPGTIDDELYPHQAKVQVFLLLMALVCIPWLLLVKPLHFKFTHKKKSHEPLPST 671

  Fly   702 TSDAEAGGVS------------------NSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVS 748
            .:||.:..:.                  .|||||        |:..:|.|||.|||||:.|..||
Yeast   672 EADASSEDLEAQQLISAMDADDAEEEEVGSGSHG--------EDFGDIMIHQVIHTIEFCLNCVS 728

  Fly   749 HTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSA 813
            ||||||||||||||||||:.|||||.:.|.....|.||..:...:||.|..||..:||||||.||
Yeast   729 HTASYLRLWALSLAHAQLSSVLWTMTIQIAFGFRGFVGVFMTVALFAMWFALTCAVLVLMEGTSA 793

  Fly   814 FLHTLRLHWVEFQSKFYKGQGYAFQPFSFD 843
            .||:|||||||..|||:.|:|..::||:|:
Yeast   794 MLHSLRLHWVESMSKFFVGEGLPYEPFAFE 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	326/848 (38%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	326/847 (38%)
VPH1	NP_014913.3	V_ATPase_I	31..822	CDD:396194	326/848 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344191
Domainoid	1	1.000	584	1.000	Domainoid score	I29
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3795
Inparanoid	1	1.050	609	1.000	Inparanoid score	I127
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	1	1.010	-	-		QHG53812
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		mtm9226
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	LDO	PTHR11629
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2333
SonicParanoid	1	1.000	-	-		X226
TreeFam	1	0.960	-	-
	16	15.740