Protein Alignment Vha100-1 and atp6v0a2a

DIOPT Version :10

• Sequence 1: NP_651672.1
• Gene: Vha100-1 / 43442
• FlyBaseID: FBgn0028671
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: XP_009303407.1
• Gene: atp6v0a2a / 561469
• ZFINID: ZDB-GENE-091113-4
• Length: 848
• Species: Danio rerio
• Alignment Length: 878
• Identity: 403/878 - (45%)
• Similarity: 564/878 - (64%)
• Gaps: 73/878 - (8%)

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |||.||||||.|.||||||.:||||:|||||:|||:||||||.|::|||:||:|::||:||||.|
Zfish     1 MGSGFRSEEMCLAQLFLQSGSAYACISELGEMGLVEFRDLNPSVSSFQRRFVSEIKRCEEMERIL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            .||.:||:|..|.:.:....|.||.|:.::::....::||.||.||.:|.|.|:||.|||.|..|
Zfish    66 GYLLREIRKANIAVPEAEVPPVAPAPKNVLEIMEQLQRLEVELSEVAKNKEKLQRNLLELMEYTH 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRY-PQMADNQNEDEQAQLLGEEGVRASQPGQNL--K 192
            :||.|:.|             .:|.|::... ||.       |:...|..|.|......|.|  |
Zfish   131 MLRITRSF-------------VHSRSRHEALGPQY-------EEFPSLETESVTGCTSMQRLGAK 175

  Fly   193 LGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTR 257
            ||||:|:|.|.::.||||||||.|:|...|..|.::..|.|...|:.....||:|.|.|||:..:
Zfish   176 LGFVSGLIQRVKVEAFERMLWRVCKGYTILSYAEVDESLADLDTGEIRKNVVFLISFWGDQIGQK 240

  Fly   258 VKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKV 322
            |:|||:.:...:||.||...:|.::...:.|||:||:.||.:|:|:..:||..|:::.::|.::|
Zfish   241 VQKICDCYHCHIYPHPETDEERADVMDSLRTRIQDLHNVLHRTEDYLKQVLHKASESAQSWVLQV 305

  Fly   323 RKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPP 387
            :|:|||||.|||.:.|||.||||||.|.|:.|:..::.||..|:.:..::||..:||:.:.:.||
Zfish   306 KKMKAIYHILNLCSFDVTNKCLIAEVWCPVSDLANLRRALEEGSRKGDATVPSFVNRIPSSDTPP 370

  Fly   388 TYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKE 452
            |..|:||||..||::::||||..|||::|||:|||||||||||||||||||:::.||.|||:..|
Zfish   371 TLLRSNKFTSGFQSIVEAYGVGDYREVSPAPFTIITFPFLFAVMFGDLGHGSVLTLFALWMVLTE 435

  Fly   453 KGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL-------SYNK 510
            |....::..|||....|.|||||.:||:||:||||||||.||||||||||.|.:       .:..
Zfish   436 KDHTRRRPGNEIRMTLFDGRYIILMMGLFSIYTGLIYNDCFSKSLNIFGSAWSVKAMFTEQEWTN 500

  Fly   511 STVMENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVM 573
            .|:..|..|.|:|  .|.:.| |||.|:||||.:| .|::.|.|:||||:|:|.||:||.||||:
Zfish   501 ETLRSNMLLTLNPNVSGVFSG-PYPLGIDPIWNMA-VNRLTFLNSYKMKMSVIIGVVHMSFGVVL 563

  Fly   574 SWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFID 638
            |..||.:||.:..:...|:|:|:|||.||.|:..::|.||:.:.|.:.:     .||||||.||:
Zfish   564 SVFNHLHFRQKYKIYLLFLPELLFLLCLFGYLAFMIFYKWLAYTARDSQ-----LAPSILIHFIN 623

  Fly   639 MVLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLI----------------- 686
            |.|...      |..:.::.||..:||..|:||:..:||:||.|||.:
Zfish   624 MFLMQA------NATSPLYPGQMGLQVFLVVVALLSVPVLLLGKPLYLYWLHHGGKSLGIHRVCL 682

  Fly   687 ----MQARKQANVQPIAGATSDAEAGGVSNSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSV 747
                .:..::.:.:.::.:....|..|:|.||.       .:|.:..::|:||:||||||.||.:
Zfish   683 CSCGYERVRRVSEEDLSPSVVHDEEEGLSESGG-------PQEFDFGDVFLHQAIHTIEYSLGCI 740

  Fly   748 SHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLS 812
            |:|||||||||||||||||:||||.||:.:||:....:|.|.|..||:.:|:||:.||::|||||
Zfish   741 SNTASYLRLWALSLAHAQLSEVLWAMVMRLGLRISSRLGVIFLVPVFSVFAVLTISILLVMEGLS 805

  Fly   813 AFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAI 845
            ||||.|||||||||:|||.|.|..|.||.|..:
Zfish   806 AFLHALRLHWVEFQNKFYSGAGVKFAPFDFSLL 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	V_ATPase_I	27..842	CDD:460232	382/847 (45%)
atp6v0a2a	XP_009303407.1	V_ATPase_I	27..835	CDD:460232	382/847 (45%)