DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-1 and atp6v0a2a

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_009303407.1	Gene:	atp6v0a2a / 561469	ZFINID:	ZDB-GENE-091113-4	Length:	848	Species:	Danio rerio

Alignment Length:	878	Identity:	403/878 - (45%)
Similarity:	564/878 - (64%)	Gaps:	73/878 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |||.||||||.|.||||||.:||||:|||||:|||:||||||.|::|||:||:|::||:||||.|
Zfish     1 MGSGFRSEEMCLAQLFLQSGSAYACISELGEMGLVEFRDLNPSVSSFQRRFVSEIKRCEEMERIL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            .||.:||:|..|.:.:....|.||.|:.::::....::||.||.||.:|.|.|:||.|||.|..|
Zfish    66 GYLLREIRKANIAVPEAEVPPVAPAPKNVLEIMEQLQRLEVELSEVAKNKEKLQRNLLELMEYTH 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRY-PQMADNQNEDEQAQLLGEEGVRASQPGQNL--K 192
            :||.|:.|             .:|.|::... ||.       |:...|..|.|......|.|  |
Zfish   131 MLRITRSF-------------VHSRSRHEALGPQY-------EEFPSLETESVTGCTSMQRLGAK 175

  Fly   193 LGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTR 257
            ||||:|:|.|.::.||||||||.|:|...|..|.::..|.|...|:.....||:|.|.|||:..:
Zfish   176 LGFVSGLIQRVKVEAFERMLWRVCKGYTILSYAEVDESLADLDTGEIRKNVVFLISFWGDQIGQK 240

  Fly   258 VKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKV 322
            |:|||:.:...:||.||...:|.::...:.|||:||:.||.:|:|:..:||..|:::.::|.::|
Zfish   241 VQKICDCYHCHIYPHPETDEERADVMDSLRTRIQDLHNVLHRTEDYLKQVLHKASESAQSWVLQV 305

  Fly   323 RKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPP 387
            :|:|||||.|||.:.|||.||||||.|.|:.|:..::.||..|:.:..::||..:||:.:.:.||
Zfish   306 KKMKAIYHILNLCSFDVTNKCLIAEVWCPVSDLANLRRALEEGSRKGDATVPSFVNRIPSSDTPP 370

  Fly   388 TYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKE 452
            |..|:||||..||::::||||..|||::|||:|||||||||||||||||||:::.||.|||:..|
Zfish   371 TLLRSNKFTSGFQSIVEAYGVGDYREVSPAPFTIITFPFLFAVMFGDLGHGSVLTLFALWMVLTE 435

  Fly   453 KGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL-------SYNK 510
            |....::..|||....|.|||||.:||:||:||||||||.||||||||||.|.:       .:..
Zfish   436 KDHTRRRPGNEIRMTLFDGRYIILMMGLFSIYTGLIYNDCFSKSLNIFGSAWSVKAMFTEQEWTN 500

  Fly   511 STVMENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVM 573
            .|:..|..|.|:|  .|.:.| |||.|:||||.:| .|::.|.|:||||:|:|.||:||.||||:
Zfish   501 ETLRSNMLLTLNPNVSGVFSG-PYPLGIDPIWNMA-VNRLTFLNSYKMKMSVIIGVVHMSFGVVL 563

  Fly   574 SWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFID 638
            |..||.:||.:..:...|:|:|:|||.||.|:..::|.||:.:.|.:.:     .||||||.||:
Zfish   564 SVFNHLHFRQKYKIYLLFLPELLFLLCLFGYLAFMIFYKWLAYTARDSQ-----LAPSILIHFIN 623

  Fly   639 MVLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLI----------------- 686
            |.|...      |..:.::.||..:||..|:||:..:||:||.|||.:
Zfish   624 MFLMQA------NATSPLYPGQMGLQVFLVVVALLSVPVLLLGKPLYLYWLHHGGKSLGIHRVCL 682

  Fly   687 ----MQARKQANVQPIAGATSDAEAGGVSNSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSV 747
                .:..::.:.:.::.:....|..|:|.||.       .:|.:..::|:||:||||||.||.:
Zfish   683 CSCGYERVRRVSEEDLSPSVVHDEEEGLSESGG-------PQEFDFGDVFLHQAIHTIEYSLGCI 740

  Fly   748 SHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLS 812
            |:|||||||||||||||||:||||.||:.:||:....:|.|.|..||:.:|:||:.||::|||||
Zfish   741 SNTASYLRLWALSLAHAQLSEVLWAMVMRLGLRISSRLGVIFLVPVFSVFAVLTISILLVMEGLS 805

  Fly   813 AFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAI 845
            ||||.|||||||||:|||.|.|..|.||.|..:
Zfish   806 AFLHALRLHWVEFQNKFYSGAGVKFAPFDFSLL 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	382/847 (45%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	381/846 (45%)
atp6v0a2a	XP_009303407.1	NtpI	26..833	CDD:224188	380/846 (45%)
atp6v0a2a	XP_009303407.1	V_ATPase_I	28..835	CDD:279793	381/846 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.830