DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-1 and atp6v0a1b

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_009295518.1	Gene:	atp6v0a1b / 553691	ZFINID:	ZDB-GENE-050522-215	Length:	868	Species:	Danio rerio

Alignment Length:	906	Identity:	527/906 - (58%)
Similarity:	644/906 - (71%)	Gaps:	102/906 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            ||.|||||||.|.||||||||||.|||||||||:|||||||||||.||||||||||||:||:|||
Zfish     1 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGMVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            |::||||||..||.:||||:||.|.||:|||||||||||||||:|:|.|.||||:||||||||||
Zfish    66 RFVEKEIKKANIPTMDTGENPEVPFPRDMIDLEATFEKLENELKEINTNQEALKKNFLELTELKH 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLL--GEEGVRASQPGQNLKL 193
            |||:||.||||                      |.|....:|.:.||  .|.|     .|..|:|
Zfish   131 ILRRTQQFFDE----------------------MEDPNLLEESSSLLDPSEAG-----RGAPLRL 168

  Fly   194 GFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRV 258
            |||||||.|||:|.|||||||.|||||||||..||.||||||.|||||||||||||||||||.||
Zfish   169 GFVAGVINRERIPTFERMLWRVCRGNVFLRQTEIEDPLEDPTTGDQVHKSVFIIFFQGDQLKNRV 233

  Fly   259 KKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVR 323
            |||||||||:||||||.|.:|:|||.||.|||:||..||.||:|||.|||.||||.::.||:|||
Zfish   234 KKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKTMRVWFIKVR 298

  Fly   324 KIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPT 388
            |:|||||||||.|:||||||||||.|.|:.|:::||.|||||||||||:||.|||||||.:.|||
Zfish   299 KMKAIYHTLNLCNIDVTQKCLIAEVWCPVSDLDSIQFALRRGTERSGSTVPSILNRMQTKQTPPT 363

  Fly   389 YNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEK 453
            ||:|||||..||.::||||:.:|||:||||||||||||||||||||:|||.:|....|:::.:|.
Zfish   364 YNKTNKFTSGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDMGHGVLMTSAALYLVLRET 428

  Fly   454 GLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL--------SYNK 510
            .|.|||:|||::|:.|.|||||.|||:||:||||||||.||||||:|.|.|.:        ::..
Zfish   429 RLLAQKSDNEMFNMIFAGRYIILLMGMFSVYTGLIYNDCFSKSLNMFSSGWSVRPMFAPNGNWTD 493

  Fly   511 STVMENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVM 573
            .|:..|..|||:|  .|.: |.|||.|:||||.:| |||:.|.|::|||:|:|.|||||:|||.:
Zfish   494 QTLESNSVLQLNPSVSGVF-GGPYPLGIDPIWNIA-ANKLTFLNSFKMKMSVILGVIHMLFGVTL 556

  Fly   574 SWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFID 638
            |..||.||:..:::...|||::||:..||.|::||:|.|||.:.|...|.     |||:||.||:
Zfish   557 SLFNHLYFKKPLNIFLNFIPEIVFMSSLFGYLILLIFYKWIAYDAVTSKD-----APSLLIAFIN 616

  Fly   639 MVLFN----TPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQ----------- 688
            |.|||    |.||        ::.||..||.|.|::|:.|:||||:.|.:::.:
Zfish   617 MCLFNYNDPTNKP--------LYRGQAGIQSLLVVIALACVPVMLVVKTMILRRQHLWKKHLSQM 673

  Fly   689 --ARKQANVQPIAGATSDAEAGGVSNSGSH--GG--------------------------GGGHE 723
              ||...|::.:. .|..:...|::..|:.  ||                          |..|.
Zfish   674 RDARPAENLETLE-QTGTSSPPGLTQQGTQKFGGVRVGNGPTEDEAEIIDHDQLSQHSEEGDEHS 737

  Fly   724 EEE--ELSEIFIHQSIHTIEYVLGSVSHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVG 786
            |||  ...::.:||:||||||.||.:|:|||||||||||||||||:||||.||:.:||......|
Zfish   738 EEEPFNFGDMAVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWGMVMRLGLSSRSGGG 802

  Fly   787 GIVLTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAIIE 847
            ...|:.:|:.:|.|||.||::|||||||||.|||||||||:|||.|||:.|.||||::|:|
Zfish   803 FFGLSIIFSAFATLTVCILLIMEGLSAFLHALRLHWVEFQNKFYTGQGFKFVPFSFESILE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	501/873 (57%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	500/872 (57%)
atp6v0a1b	XP_009295518.1	NtpI	27..860	CDD:224188	503/875 (57%)
atp6v0a1b	XP_009295518.1	V_ATPase_I	28..858	CDD:279793	500/872 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582320
Domainoid	1	1.000	963	1.000	Domainoid score	I34
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1011	1.000	Inparanoid score	I279
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		otm25283
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	LDO	PTHR11629
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2333
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800