DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-1 and tcirg1

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_012809053.3	Gene:	tcirg1 / 549603	XenbaseID:	XB-GENE-5721917	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	861	Identity:	391/861 - (45%)
Similarity:	549/861 - (63%)	Gaps:	55/861 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            ||||||.|||.|.||||||.:.|.|||.|||||||:|||||.:||:|||::|:|:|||||||...
Frog    43 MGSLFRGEEMCLAQLFLQSGSEYQCVSALGELGLVEFRDLNQNVNSFQRRYVSEIRRCDEMETTF 107

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            .|||:|::|.|:.:.::..||.||.||:.|.::...|:|..|||||:||.:.|:....||.|..:
Frog   108 SYLERELRKAGVQVPESEMSPPAPLPRDAIRMQEESEQLAKELREVSQNRQTLQERLRELLEYAN 172

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLKLGF 195
            |||::|.|           :|....|:    .|..|...:|   .||....|..    |:|::.|
Frog   173 ILRESQRF-----------TGPLLESE----AQWKDRSEDD---PLLDPAVVNK----QDLRVSF 215

  Fly   196 VAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRVKK 260
            :||||...|:.:|||:|||||||.:.:....:..|:||...|:.|.:.:|:|.:.|:::..::||
Frog   216 MAGVIHPWRMNSFERLLWRACRGYLIVNFVEMSEPMEDLVTGESVTQIIFLISYWGEKIGEKIKK 280

  Fly   261 ICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVRKI 325
            |...|...:||..:....|.|....::.:|:|:..||.||:.:..:||..||..|.:|.|.|||:
Frog   281 IANCFHCHIYPYADDETSRLETLRNLLVQIQDMQKVLLQTEGYLSQVLSRAASALHHWRVSVRKM 345

  Fly   326 KAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPTYN 390
            |.||..|||  ..|.::|||.|.|.|::|:..:|.||.|.:|.||.......:|:....:|||..
Frog   346 KHIYLILNL--CSVRERCLIGEVWCPVVDLPLLQSALTRASESSGGGGESFCHRIPCAFSPPTLI 408

  Fly   391 RTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEKGL 455
            ||||||..||.::||||||:|:|:|||.::||||||||||||||:||||||.||.||::..|...
Frog   409 RTNKFTSGFQGIVDAYGVATYQEVNPAIFSIITFPFLFAVMFGDVGHGAIMFLFALWLVLGENDP 473

  Fly   456 AAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL-----SYNKSTVME 515
            ..:::::||:::.|||||:|.|||..|:|||.:||:.||:...||.|.|.:     :.|.::...
Frog   474 KLRRSEDEIFSMCFGGRYLILLMGALSVYTGFVYNECFSRPAVIFNSGWSVASMARANNWTSDSI 538

  Fly   516 NKF--LQLSPK--GDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWH 576
            ||.  :.|:|.  |.:. ||||||:||||.:| .|::.|.|::|||:|:|.||.||.|||.:|..
Frog   539 NKLPPIPLNPNITGVFT-APYPFGIDPIWSLA-VNRLTFLNSFKMKMSVILGVCHMAFGVCLSVF 601

  Fly   577 NHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDMVL 641
            |..:||....:....:|:|:|||.||.|:|.::..|||...|.:.:     .||||||.||||.|
Frog   602 NFVHFRQIYRIFLITLPELLFLLCLFGYLVFMVVYKWIVLTAEDAE-----WAPSILIHFIDMFL 661

  Fly   642 FNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIM---QARKQANVQPIAGATS 703
            | |..|...:    ::.||..:|.:.|:||:.||||:||..|:.::   :::|.::.|......:
Frog   662 F-TQNPGNRD----LYQGQQVVQTVLVIVAILCIPVLLLGDPICLLIQHRSKKDSSHQNRCSLNN 721

  Fly   704 -DAEA---GGVSNSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASYLRLWALSLAHA 764
             |.||   ..::....||.|   .|:.:.:|:|:||.||||||.||.:|:|||||||||||||||
Frog   722 GDREALLEDEITVPTGHGHG---SEKFDTAEVFMHQMIHTIEYCLGCISNTASYLRLWALSLAHA 783

  Fly   765 QLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWVEFQSKF 829
            ||:||||.||:.||..:.....||||..:|||:|:|||.||::|||||||||.|||||||||:||
Frog   784 QLSEVLWNMVIRIGFSKLSLTWGIVLVPIFAFFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKF 848

  Fly   830 YKGQGYAFQPFSFDAI 845
            |.|:||.|.||.|:.:
Frog   849 YSGEGYKFFPFCFETM 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	371/830 (45%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	370/829 (45%)
tcirg1	XP_012809053.3	V_ATPase_I	69..861	CDD:396194	371/830 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030