Protein Alignment Vha100-1 and atp6v0a2

DIOPT Version :10

• Sequence 1: NP_651672.1
• Gene: Vha100-1 / 43442
• FlyBaseID: FBgn0028671
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001016223.1
• Gene: atp6v0a2 / 548977
• XenbaseID: XB-GENE-960957
• Length: 845
• Species: Xenopus tropicalis
• Alignment Length: 880
• Identity: 405/880 - (46%)
• Similarity: 562/880 - (63%)
• Gaps: 74/880 - (8%)

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |||.||||.|.|.||||||.:||.|||||||:||.:||||||.|:|||||||.||::|:||||.|
 Frog     1 MGSFFRSEAMCLAQLFLQSGSAYDCVSELGEMGLAEFRDLNPQVSAFQRKFVGEVKKCEEMERIL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            .||.:||:|..||:.:...:||||.|:.::|::...:|||.||||||:|.|.|::|.||:.|..:
 Frog    66 GYLMQEIQKANIPVPEESLTPEAPLPKHVLDIQEQLQKLEVELREVNKNKEKLQKNLLEMIEYTY 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSS--SKYRRYPQMADNQNEDEQA-QLLGEEGVRASQPGQNLK 192
            :||.|...       |::|:...:|  |.|..:|.:......|... |.||            .|
 Frog   131 MLRVTNYL-------VHRSNEHETSAHSTYEEFPALEKESLIDYTCMQRLG------------AK 176

  Fly   193 LGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTR 257
            ||||:|::.|.:|.:||:||||.|:|...|....::..|..|...:.....||::.:.|||:..:
 Frog   177 LGFVSGLVHRAKLESFEKMLWRVCKGYTVLTYQELDEYLLHPDTEEPTRWFVFVVSYWGDQIGQK 241

  Fly   258 VKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKV 322
            ||||||.:...|||...:..:||.:...:.|||:||:.|:.||.|:..:||..|::::..|.:::
 Frog   242 VKKICECYDCHLYPYTNSAEERRNLLSELNTRIQDLHKVISQTDDYLKQVLFKASESVYKWVIQI 306

  Fly   323 RKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPP 387
            :|:|||||.||....|||.||||||.|.|:.|:..::.||..|:.:||.|||..:||:.:.:.||
 Frog   307 KKMKAIYHVLNFCRFDVTNKCLIAEVWCPVADLPNVRRALEEGSRKSGVSVPSFINRIPSNDTPP 371

  Fly   388 TYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKE 452
            |..||||||..||.::|||||.:||||||||||||||||||||||||.|||.:|:||.|.|:..|
 Frog   372 TLIRTNKFTSGFQNIVDAYGVGNYREMNPAPYTIITFPFLFAVMFGDFGHGILMSLFALCMVVFE 436

  Fly   453 KGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLSYN------KS 511
            |.....::.:||...||.|||||.|||:||:||||||||.||||:|||||.|::|..      ::
 Frog   437 KSPKLARSQDEIMKTFFEGRYIILLMGLFSIYTGLIYNDCFSKSMNIFGSSWNVSAMFSSNVWRT 501

  Fly   512 TVMENKFLQLSPK--GDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMS 574
            ..:.||||.|:|.  |...|. ||.|:||||.:: .|::.|.|::|||:|:|.|||||.||||:|
 Frog   502 QDLSNKFLTLNPNVTGVLTGV-YPVGIDPIWSLS-TNRLSFLNSFKMKMSVILGVIHMTFGVVLS 564

  Fly   575 WHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDM 639
            ..|:.:|:.|..:...|||:|:|::.:|.|:|.::..||:.::|.:.:.     |||||:.||:|
 Frog   565 AFNYMHFKKRFCIFLVFIPELLFMICIFGYLVFMILYKWLAYSAADSRN-----APSILLHFINM 624

  Fly   640 VLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQAR-------------- 690
            .:|:.....|.     :|.||..||:..:::...|:||:|..|||.:....
 Frog   625 FMFSKNDQIPA-----LFTGQVGIQIFLIVLVTLCVPVLLFGKPLYLYWQHHGGQTLRNYRKGYT 684

  Fly   691 --KQANVQPIAGATS-DAEAGGVSNSGSHGGGGGHE-------EEEELSEIFIHQSIHTIEYVLG 745
              ::.:.:.|:...| |.|.|.:::|        ||       |:.:.:::|:.|:||||||.||
 Frog   685 LVRRGSEEEISLVRSHDLEEGEINSS--------HEVQRDRDKEKFDFADVFMSQAIHTIEYCLG 741

  Fly   746 SVSHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEG 810
            .:|:||.||||||||||||||:||||.|::..||..|..||..||..:||.:|.||:.||::|||
 Frog   742 CISNTALYLRLWALSLAHAQLSEVLWGMIMRKGLNVEPSVGVFVLIPLFAVFAFLTIAILLVMEG 806

  Fly   811 LSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAI 845
            ||||||.|||||||||:|||.|.||.|.||||..|
 Frog   807 LSAFLHALRLHWVEFQNKFYTGAGYKFNPFSFKHI 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	V_ATPase_I	27..842	CDD:460232	383/849 (45%)
atp6v0a2	NP_001016223.1	V_ATPase_I	27..838	CDD:460232	383/849 (45%)