DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-1 and atp6v0a2

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001016223.1	Gene:	atp6v0a2 / 548977	XenbaseID:	XB-GENE-960957	Length:	845	Species:	Xenopus tropicalis

Alignment Length:	880	Identity:	405/880 - (46%)
Similarity:	562/880 - (63%)	Gaps:	74/880 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |||.||||.|.|.||||||.:||.|||||||:||.:||||||.|:|||||||.||::|:||||.|
Frog     1 MGSFFRSEAMCLAQLFLQSGSAYDCVSELGEMGLAEFRDLNPQVSAFQRKFVGEVKKCEEMERIL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            .||.:||:|..||:.:...:||||.|:.::|::...:|||.||||||:|.|.|::|.||:.|..:
Frog    66 GYLMQEIQKANIPVPEESLTPEAPLPKHVLDIQEQLQKLEVELREVNKNKEKLQKNLLEMIEYTY 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSS--SKYRRYPQMADNQNEDEQA-QLLGEEGVRASQPGQNLK 192
            :||.|...       |::|:...:|  |.|..:|.:......|... |.||            .|
Frog   131 MLRVTNYL-------VHRSNEHETSAHSTYEEFPALEKESLIDYTCMQRLG------------AK 176

  Fly   193 LGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTR 257
            ||||:|::.|.:|.:||:||||.|:|...|....::..|..|...:.....||::.:.|||:..:
Frog   177 LGFVSGLVHRAKLESFEKMLWRVCKGYTVLTYQELDEYLLHPDTEEPTRWFVFVVSYWGDQIGQK 241

  Fly   258 VKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKV 322
            ||||||.:...|||...:..:||.:...:.|||:||:.|:.||.|:..:||..|::::..|.:::
Frog   242 VKKICECYDCHLYPYTNSAEERRNLLSELNTRIQDLHKVISQTDDYLKQVLFKASESVYKWVIQI 306

  Fly   323 RKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPP 387
            :|:|||||.||....|||.||||||.|.|:.|:..::.||..|:.:||.|||..:||:.:.:.||
Frog   307 KKMKAIYHVLNFCRFDVTNKCLIAEVWCPVADLPNVRRALEEGSRKSGVSVPSFINRIPSNDTPP 371

  Fly   388 TYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKE 452
            |..||||||..||.::|||||.:||||||||||||||||||||||||.|||.:|:||.|.|:..|
Frog   372 TLIRTNKFTSGFQNIVDAYGVGNYREMNPAPYTIITFPFLFAVMFGDFGHGILMSLFALCMVVFE 436

  Fly   453 KGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLSYN------KS 511
            |.....::.:||...||.|||||.|||:||:||||||||.||||:|||||.|::|..      ::
Frog   437 KSPKLARSQDEIMKTFFEGRYIILLMGLFSIYTGLIYNDCFSKSMNIFGSSWNVSAMFSSNVWRT 501

  Fly   512 TVMENKFLQLSPK--GDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMS 574
            ..:.||||.|:|.  |...|. ||.|:||||.:: .|::.|.|::|||:|:|.|||||.||||:|
Frog   502 QDLSNKFLTLNPNVTGVLTGV-YPVGIDPIWSLS-TNRLSFLNSFKMKMSVILGVIHMTFGVVLS 564

  Fly   575 WHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDM 639
            ..|:.:|:.|..:...|||:|:|::.:|.|:|.::..||:.::|.:.:.     |||||:.||:|
Frog   565 AFNYMHFKKRFCIFLVFIPELLFMICIFGYLVFMILYKWLAYSAADSRN-----APSILLHFINM 624

  Fly   640 VLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQAR-------------- 690
            .:|:.....|.     :|.||..||:..:::...|:||:|..|||.:....
Frog   625 FMFSKNDQIPA-----LFTGQVGIQIFLIVLVTLCVPVLLFGKPLYLYWQHHGGQTLRNYRKGYT 684

  Fly   691 --KQANVQPIAGATS-DAEAGGVSNSGSHGGGGGHE-------EEEELSEIFIHQSIHTIEYVLG 745
              ::.:.:.|:...| |.|.|.:::|        ||       |:.:.:::|:.|:||||||.||
Frog   685 LVRRGSEEEISLVRSHDLEEGEINSS--------HEVQRDRDKEKFDFADVFMSQAIHTIEYCLG 741

  Fly   746 SVSHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEG 810
            .:|:||.||||||||||||||:||||.|::..||..|..||..||..:||.:|.||:.||::|||
Frog   742 CISNTALYLRLWALSLAHAQLSEVLWGMIMRKGLNVEPSVGVFVLIPLFAVFAFLTIAILLVMEG 806

  Fly   811 LSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAI 845
            ||||||.|||||||||:|||.|.||.|.||||..|
Frog   807 LSAFLHALRLHWVEFQNKFYTGAGYKFNPFSFKHI 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	383/849 (45%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	382/848 (45%)
atp6v0a2	NP_001016223.1	NtpI	27..839	CDD:224188	384/850 (45%)
atp6v0a2	NP_001016223.1	V_ATPase_I	28..838	CDD:279793	382/848 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11629
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110