Protein Alignment Vha100-1 and ATP6V0A1

DIOPT Version :10

• Sequence 1: NP_651672.1
• Gene: Vha100-1 / 43442
• FlyBaseID: FBgn0028671
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001365459.1
• Gene: ATP6V0A1 / 535
• HGNCID: 865
• Length: 903
• Species: Homo sapiens
• Alignment Length: 934
• Identity: 531/934 - (56%)
• Similarity: 643/934 - (68%)
• Gaps: 123/934 - (13%)

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            ||.|||||||.|.||||||||||.|||||||||.|||||||||||.||||||||||||:||:|||
Human     1 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            |::||||:|..||::||||:||.|.||:||||||.|||:||||:|:|.|.||||||||||||||.
Human    66 RFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKF 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLKLGF 195
            ||||||.||||                      |||....:|.:.||....:....|   |:|||
Human   131 ILRKTQQFFDE----------------------MADPDLLEESSSLLEPSEMGRGTP---LRLGF 170

  Fly   196 VAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPT------------------------- 235
            |||||.|||:|.|||||||.||||||||||.||.|||||.
Human   171 VAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTVESHSVVQARVQWRDLGSPQPPLP 235

  Fly   236 ----------------NGDQVHKSVFIIFFQGDQLKTRVKKICEGFRATLYPCPEAPADRREMAM 284
                            .||.||||||||||||||||.|||||||||||:||||||.|.:|:|||.
Human   236 GFKRFSCLSLPSSWGLQGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMAS 300

  Fly   285 GVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVRKIKAIYHTLNLFNLDVTQKCLIAECW 349
            ||.|||:||..||.||:|||.|||.|||||::.||:||||:|||||||||.|:||||||||||.|
Human   301 GVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVW 365

  Fly   350 VPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPTYNRTNKFTKAFQALIDAYGVASYREM 414
            .|:.|:::||.|||||||.|||:||.|||||||.:.|||||:|||||..||.::||||:.:|||:
Human   366 CPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREI 430

  Fly   415 NPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEKGLAAQKTDNEIWNIFFGGRYIIFLMG 479
            ||||||||||||||||||||.|||.:|.||.:||:.:|..:.:||.:||:::..|.|||||.|||
Human   431 NPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMG 495

  Fly   480 VFSMYTGLIYNDIFSKSLNIFGSHWHL----SYN--KSTVMENKFLQLSP--KGDYEGAPYPFGM 536
            ||||||||||||.||||||||||.|.:    :||  :.|:..|..|||:|  .|.: |.|||||:
Human   496 VFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGVF-GGPYPFGI 559

  Fly   537 DPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWHNHTYFRNRISLLYEFIPQLVFLLLL 601
            ||||.:| .||:.|.|::|||:|:|.|:|||:|||.:|..||.||:..:::.:.|||:::|:..|
Human   560 DPIWNIA-TNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSL 623

  Fly   602 FFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDMVLFNTPKPPPENCETYMFMGQHFIQVL 666
            |.|:|:|:|.||..:.|     ::...|||:||.||:|.||:.    ||:..:.::.||..||..
Human   624 FGYLVILIFYKWTAYDA-----HTSENAPSLLIHFINMFLFSY----PESGYSMLYSGQKGIQCF 679

  Fly   667 FVLVAVGCIPVMLLAKPLLIMQ---ARKQANVQPI----------AGATSDAEAGGVSN-SGSHG 717
            .|:||:.|:|.|||.|||::.:   .||....||:          .|..:.|.|.|..| .|...
Human   680 LVVVALLCVPWMLLFKPLVLRRQYLRRKHLEGQPVEAPVSPNPSQQGLEAAAAATGTLNFGGIRV 744

  Fly   718 GGGGHEEEEEL------------------SEIF------IHQSIHTIEYVLGSVSHTASYLRLWA 758
            |.|..||:.|:                  .|:|      :||:||||||.||.:|:|||||||||
Human   745 GNGPTEEDAEIIQHDQLSTHSEDADEPSEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWA 809

  Fly   759 LSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWV 823
            ||||||||:|||||||:.|||..:...||:||...|..:|.|||.||::|||||||||.||||||
Human   810 LSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWV 874

  Fly   824 EFQSKFYKGQGYAFQPFSFDAIIE 847
            |||:|||.|.|:.|.||||:.|.|
Human   875 EFQNKFYSGTGFKFLPFSFEHIRE 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	V_ATPase_I	27..842	CDD:460232	505/901 (56%)
ATP6V0A1	NP_001365459.1	V_ATPase_I	27..893	CDD:460232	505/901 (56%)