DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-1 and ATP6V0A4

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_065683.2	Gene:	ATP6V0A4 / 50617	HGNCID:	866	Length:	840	Species:	Homo sapiens

Alignment Length:	877	Identity:	466/877 - (53%)
Similarity:	619/877 - (70%)	Gaps:	59/877 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |.|:||||||.|.|||||.||||.||:||||||||||:|||.:||:||||||||||||:.:||.|
Human     1 MVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERIL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            |:||.|::.:.:..| ..:||..|.|||||.||...||||.||:|.|||.:|||::||||||||:
Human    66 RFLEDEMQNEIVVQL-LEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTELKY 129

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLKLGF 195
            :|:|||.||:...                   .:||:...::.:.||..:.|.|...|   ||||
Human   130 LLKKTQDFFETET-------------------NLADDFFTEDTSGLLELKAVPAYMTG---KLGF 172

  Fly   196 VAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRVKK 260
            :||||.|||:.:|||:|||.|||||:|:.:.::.|||||...:::.|::||||:||:||:.::||
Human   173 IAGVINRERMASFERLLWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKK 237

  Fly   261 ICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVRKI 325
            ||:|||||:|||||...:||||...|..|:|||.||:.||:.||.|:|..||.|..:|.:||:|:
Human   238 ICDGFRATVYPCPEPAVERREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKM 302

  Fly   326 KAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPTYN 390
            ||:||.||:.|:||||:|:|||.|.|:.|...|:.||.:|.|.||||:.||:..:|:...|||:|
Human   303 KAVYHILNMCNIDVTQQCVIAEIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSKTAPPTFN 367

  Fly   391 RTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEKGL 455
            ||||||..||.::|||||.||||:||||||||||||||||||||.|||.:|.|..||||..|:.|
Human   368 RTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRL 432

  Fly   456 AAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL-------SYNKSTV 513
            .:|||||||||.||.|||:|.|||:||:||||||||.||||||||||.|.:       ::|...:
Human   433 LSQKTDNEIWNTFFHGRYLILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVM 497

  Fly   514 MENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWH 576
            .|:.:|||.|  .|.|.|.|||||:||||.:| :||:.|.|:||||:|:|.|::.|:|||::|..
Human   498 EESLYLQLDPAIPGVYFGNPYPFGIDPIWNLA-SNKLTFLNSYKMKMSVILGIVQMVFGVILSLF 561

  Fly   577 NHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDMVL 641
            ||.|||..::::.:|||:::|:|.||.|:|.::..||..|    |...|:. ||||||.||:|.|
Human   562 NHIYFRRTLNIILQFIPEMIFILCLFGYLVFMIIFKWCCF----DVHVSQH-APSILIHFINMFL 621

  Fly   642 FNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQANVQP--------- 697
            ||.    .::....::..|..:|..||::|:..:|.|||.||.::..:.:::.:|.
Human   622 FNY----SDSSNAPLYKHQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQEDATE 682

  Fly   698 -IAGATS--DAEAGGVSNSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASYLRLWAL 759
             |.|.:|  .:.:|..:::.:||....|.||....::|:||:||||||.||.:|:||||||||||
Human   683 NIEGDSSSPSSRSGQRTSADTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGCISNTASYLRLWAL 747

  Fly   760 SLAHAQLAEVLWTMVLSIGLKQEGPVGGIV-LTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWV 823
            |||||||:|||||||::.||:..| .|||| :..:||.:|:|||.||::|||||||||.||||||
Human   748 SLAHAQLSEVLWTMVMNSGLQTRG-WGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWV 811

  Fly   824 EFQSKFYKGQGYAFQPFSFDAIIENGAAAAEE 855
            |||:|||.|.||.|.||||..|::   ..|||
Human   812 EFQNKFYVGDGYKFSPFSFKHILD---GTAEE 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	440/836 (53%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	440/835 (53%)
ATP6V0A4	NP_065683.2	NtpI	28..831	CDD:224188	441/836 (53%)
		V_ATPase_I	28..830	CDD:279793	440/835 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..704		4/28 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	946	1.000	Domainoid score	I36
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1008	1.000	Inparanoid score	I287
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		otm41573
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.840