DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-1 and Vha100-2

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster

Alignment Length:	861	Identity:	503/861 - (58%)
Similarity:	615/861 - (71%)	Gaps:	46/861 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            ||.:||||||||||:|:|.||||..||||||.|.|||||||.:|||||||||.|||||||:|||:
  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65

  Fly    66 RYLEKEIKKDGIPMLDTGES-PEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELK 129
            ||:|.|||||||.:.|..:. |.||.|||:|||||..||.|:|:.|:.||...:|.|:||||||:
  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130

  Fly   130 HILRKTQVFF-DESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLKL 193
            .:|..||.|| |:.|..:..|:.|           ..||   |..||..|             :|
  Fly   131 KVLENTQGFFSDQEVLNLDSSNRA-----------GGDN---DAAAQHRG-------------RL 168

  Fly   194 GFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRV 258
            |||||||.|||:.||||||||..||||||:::.::.||.||..|..::|:||:.||||:|||.|:
  Fly   169 GFVAGVINRERVFAFERMLWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRI 233

  Fly   259 KKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVR 323
            ||:|.||.|:|||||.:..:|.||...|.||:|||..||.||:|||.|||...:|||.:|.:.|:
  Fly   234 KKVCTGFHASLYPCPSSHNEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVK 298

  Fly   324 KIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPT 388
            |:|||||||||||:|||:||||.|||||..|:..:|.||..|:...||::|..||.:.|.|.|||
  Fly   299 KMKAIYHTLNLFNMDVTKKCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPT 363

  Fly   389 YNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEK 453
            :|||||||:.||.||||||||||||.|||.||.|||||||||||||||||.|:.|||.||:..|:
  Fly   364 FNRTNKFTRGFQNLIDAYGVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCER 428

  Fly   454 GLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLSYNKSTVMENKF 518
            .||..:...|||||||||||||.|||:|:|||||:|||:||||:|:|||.|..:||.:||:.|..
  Fly   429 KLARIRNGGEIWNIFFGGRYIILLMGLFAMYTGLVYNDVFSKSMNLFGSRWFNNYNTTTVLTNPN 493

  Fly   519 LQLSPKGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWHNHTYFRN 583
            |||.|.....|. |||||||:||:|. |||||.|::|||:||||||:||:|||.||..|.|:|:.
  Fly   494 LQLPPNSSAVGV-YPFGMDPVWQLAD-NKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKR 556

  Fly   584 RISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKF-AATNDKPYSEACAPSILITFIDMVLFNTPKP 647
            ..|:..||:||::||||||.|||.:||.||..: |.|:.:|.:..||||:||.||:|:||...:
  Fly   557 YASIFLEFVPQILFLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTE- 620

  Fly   648 PPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQ-----------ANVQPIAGA 701
            ||:.|..:||..|..:|..|||:|:.|||.|||.|||.|...||.           .|::...|.
  Fly   621 PPKGCNEFMFESQPQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAHANHNGQLTGNIELAEGE 685

  Fly   702 TSDAEAGGVSNSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASYLRLWALSLAHAQL 766
            | ....|...|..:.||..|| ::|.:|||:|||:||||||||.::|||||||||||||||||||
  Fly   686 T-PLPTGFSGNEENAGGAHGH-DDEPMSEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQL 748

  Fly   767 AEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYK 831
            :||||.||||:|||..|..|.|.|..:|..|.:.|:.||||||||||||||||||||||.||||:
  Fly   749 SEVLWQMVLSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYE 813

  Fly   832 GQGYAFQPFSFDAIIE 847
            |.|||||||||.||::
  Fly   814 GMGYAFQPFSFKAILD 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	480/828 (58%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	479/827 (58%)
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	479/827 (58%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	475/821 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451292
Domainoid	1	1.000	601	1.000	Domainoid score	I37
eggNOG	1	0.900	-	-		E1_COG1269
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	618	1.000	Inparanoid score	I211
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		mtm1001
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	P	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
	12	11.750