DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-1 and tcirg1b

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_998234.1	Gene:	tcirg1b / 406342	ZFINID:	ZDB-GENE-040426-2022	Length:	822	Species:	Danio rerio

Alignment Length:	872	Identity:	413/872 - (47%)
Similarity:	555/872 - (63%)	Gaps:	88/872 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |||||||||:.|.||||||.:||.|||||||||:|:||||||:|||||||||||||||:|:|:..
Zfish     1 MGSLFRSEEVCLIQLFLQSGSAYNCVSELGELGIVEFRDLNPNVNAFQRKFVNEVRRCEELEKTF 65

  Fly    66 RYLEKEIKKD-------GIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFL 123
            .:||:||.:.       .|||      |.||||||::.:|...|:|..|||||::|.::|:..:.
Zfish    66 AFLEQEINRSLSQKLQPPIPM------PPAPQPRELLTIEEESERLARELREVSRNRDSLRSQYT 124

  Fly   124 ELTELKHILRKTQVFFDESVPTV-YKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQP 187
            :|.:.:.:|::|........|.| ::..|            :|:|:
Zfish   125 QLCQYRGVLKQTHSLTASQAPLVSFEPMG------------LAENR------------------- 158

  Fly   188 GQNLKLGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGD 252
             |:::|.|||||:...::|||||:|||||||.:.:....:|..||.|...:|:..:||:|.|.||
Zfish   159 -QDVRLSFVAGVVHPWKVPAFERLLWRACRGYIIVDFHEMEEKLEHPHTDEQLQWTVFLISFWGD 222

  Fly   253 QLKTRVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKN 317
            |:..:|||||:.|....:|.||..|:|.|...|:..||||:.:|:|:|:.:..::||.|...|..
Zfish   223 QIGQKVKKICDCFHTQTFPYPENQAEREETLNGLRGRIEDIKSVMGETEQYMQQLLVRALARLPE 287

  Fly   318 WFVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQT 382
            |.|:|:|.||:...|||.:..||.||||||.|.|:..:..:|.|||.|..:|||:|....||:..
Zfish   288 WVVQVQKCKAVQTVLNLCSPSVTDKCLIAEAWCPVSQLPALQSALREGGRKSGSNVDSFYNRLPA 352

  Fly   383 FENPPTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLW 447
            ..:|||...||.||..||:::||||||||||:|||.||||||||||||||||:|||.:|.|..||
Zfish   353 TTSPPTLFPTNSFTAGFQSIVDAYGVASYREVNPAVYTIITFPFLFAVMFGDVGHGLLMTLAALW 417

  Fly   448 MIRKEKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL------ 506
            ||.:|.....:|..||||.:.|||||:|.|||:||:|||.|||:.|||.|:.|.|.||:
Zfish   418 MILEENDPKLRKNTNEIWRMMFGGRYLILLMGLFSIYTGAIYNECFSKGLSTFSSGWHVRPNAEF 482

  Fly   507 -SYNKSTVMENKFLQLSPK--GDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMI 568
             ::.:.|..:|.:|.|.|.  |.:.| |||||:||||.:|. |.:.|.|:||||:|:|.|||||.
Zfish   483 YNWTEETFKKNMYLSLDPNVTGVFTG-PYPFGIDPIWGLAN-NHLTFLNSYKMKMSVIIGVIHMT 545

  Fly   569 FGVVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSIL 633
            |||.:|:.|:.:||...|:....||:|.|:|.||.|::.::..||:.:.     |.:...|||||
Zfish   546 FGVCLSFFNYIHFREVSSVFLVLIPELCFMLCLFGYLIFMVIYKWLVYG-----PVNSDSAPSIL 605

  Fly   634 ITFIDMVLF--NTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPL--LIMQARKQAN 694
            |.||||.||  |....|       ::.||..:|.:.|:|||..:||:||.||:  .:...||:.|
Zfish   606 IHFIDMFLFTENKDNKP-------LYTGQMTVQKVLVIVAVLSVPVLLLGKPIQEYLSHKRKRRN 663

  Fly   695 VQPIAGATSD-----AEAGGVSNS----GSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVSHT 750
                  .|.|     ||.|.:::.    .:.|||||.|||.:.:.:|:||:||||||.||.:|:|
Zfish   664 ------PTGDRRPLLAENGSINSQQGDVDARGGGGGEEEEFDTANVFMHQAIHTIEYCLGCISNT 722

  Fly   751 ASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFL 815
            ||||||||||||||||:|||||||:.....|...||.::...||..:|:|||.||::||||||||
Zfish   723 ASYLRLWALSLAHAQLSEVLWTMVMRQSFGQLSYVGSVMAALVFVGFAVLTVSILLVMEGLSAFL 787

  Fly   816 HTLRLHWVEFQSKFYKGQGYAFQPFSF 842
            |.|||||||||:|||.|.||...||.|
Zfish   788 HALRLHWVEFQNKFYSGTGYKLTPFDF 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	392/844 (46%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	391/843 (46%)
tcirg1b	NP_998234.1	NtpI	27..812	CDD:224188	390/842 (46%)
tcirg1b	NP_998234.1	V_ATPase_I	28..814	CDD:279793	391/843 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.930