Protein Alignment Vha100-1 and Atp6v0a1

DIOPT Version :10

• Sequence 1: NP_651672.1
• Gene: Vha100-1 / 43442
• FlyBaseID: FBgn0028671
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: XP_017452683.1
• Gene: Atp6v0a1 / 29757
• RGDID: 68405
• Length: 870
• Species: Rattus norvegicus
• Alignment Length: 894
• Identity: 522/894 - (58%)
• Similarity: 645/894 - (72%)
• Gaps: 76/894 - (8%)

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            ||.|||||||.|.||||||||||.|||||||||.|||||||||||.||||||||||||:||:|||
  Rat     1 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            |::||||:|..||::||||:||.|.||:||||||.|||:||||:|:|.|.||||||||||||||.
  Rat    66 RFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKF 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLKLGF 195
            ||||||.||||:               ...:.||||....:|.:.||....:....|   |:|||
  Rat   131 ILRKTQQFFDEA---------------ELHHQQMADPDLLEESSSLLEPNEMGRGAP---LRLGF 177

  Fly   196 VAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRVKK 260
            |||||.|||:|.|||||||.||||||||||.||.|||||..||.||||||||||||||||.||||
  Rat   178 VAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKK 242

  Fly   261 ICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVRKI 325
            |||||||:||||||.|.:|:|||.||.|||:||..||.||:|||.|||.|||||::.||:||||:
  Rat   243 ICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKM 307

  Fly   326 KAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPTYN 390
            |||||||||.|:||||||||||.|.|:.|:::||.|||||||.|||:||.|||||||.:.|||||
  Rat   308 KAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYN 372

  Fly   391 RTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEKGL 455
            :|||||..||.::||||:.:|||:||||||:|||||||||||||.|||.:|.||.:||:.:|..:
  Rat   373 KTNKFTHGFQNIVDAYGIGTYREINPAPYTVITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRI 437

  Fly   456 AAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL-------SYNKSTV 513
            .:||.:||::::.|.|||||.|||:||:||||||||.||||||||||.|.:       ::.:.|:
  Rat   438 LSQKNENEMFSMVFSGRYIILLMGLFSIYTGLIYNDCFSKSLNIFGSSWSVRPMFTIGNWTEETL 502

  Fly   514 MENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWH 576
            :.:..|||:|  .|.: |.|||||:||||.:| .||:.|.|::|||:|:|.|:|||:|||.:|..
  Rat   503 LGSSVLQLNPAIPGVF-GGPYPFGIDPIWNIA-TNKLTFLNSFKMKMSVILGIIHMLFGVSLSLF 565

  Fly   577 NHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDMVL 641
            ||.||:..:::.:.|||:::|:..||.|:|:|:|.||..:.|     :|...|||:||.||:|.|
  Rat   566 NHIYFKKPLNIYFGFIPEIIFMSSLFGYLVILIFYKWTAYDA-----HSSRNAPSLLIHFINMFL 625

  Fly   642 FNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQ---ARKQANVQPIAGATS 703
            |:.    ||:....::.||..||...::||:.|:|.|||.|||::..   .:|....||:....:
  Rat   626 FSY----PESGNAMLYSGQKGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLEGQPVEAPVT 686

  Fly   704 DAEA-----------GGVSNSGSHGGGGGHEEEEEL------------------SEIF------I 733
            .|.:           |.::..|...|.|..||:.|:                  .|:|      :
  Rat   687 PAPSQQGLEAAPAATGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDAEEPTEDEVFDFGDTMV 751

  Fly   734 HQSIHTIEYVLGSVSHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWA 798
            ||:||||||.||.:|:|||||||||||||||||:|||||||:.|||......||:.|..:||.:|
  Rat   752 HQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLHVRSLAGGLGLFFIFAAFA 816

  Fly   799 ILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAIIE 847
            .|||.||::|||||||||.|||||||||:|||.|.|:.|.||||:.|.|
  Rat   817 TLTVAILLIMEGLSAFLHALRLHWVEFQNKFYTGTGFKFLPFSFEHIRE 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	V_ATPase_I	27..842	CDD:460232	496/861 (58%)
Atp6v0a1	XP_017452683.1	V_ATPase_I	27..860	CDD:460232	496/861 (58%)