DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-1 and Atp6v0a1

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_017452683.1	Gene:	Atp6v0a1 / 29757	RGDID:	68405	Length:	870	Species:	Rattus norvegicus

Alignment Length:	894	Identity:	522/894 - (58%)
Similarity:	645/894 - (72%)	Gaps:	76/894 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            ||.|||||||.|.||||||||||.|||||||||.|||||||||||.||||||||||||:||:|||
  Rat     1 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            |::||||:|..||::||||:||.|.||:||||||.|||:||||:|:|.|.||||||||||||||.
  Rat    66 RFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKF 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLKLGF 195
            ||||||.||||:               ...:.||||....:|.:.||....:....|   |:|||
  Rat   131 ILRKTQQFFDEA---------------ELHHQQMADPDLLEESSSLLEPNEMGRGAP---LRLGF 177

  Fly   196 VAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRVKK 260
            |||||.|||:|.|||||||.||||||||||.||.|||||..||.||||||||||||||||.||||
  Rat   178 VAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKK 242

  Fly   261 ICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVRKI 325
            |||||||:||||||.|.:|:|||.||.|||:||..||.||:|||.|||.|||||::.||:||||:
  Rat   243 ICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKM 307

  Fly   326 KAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPTYN 390
            |||||||||.|:||||||||||.|.|:.|:::||.|||||||.|||:||.|||||||.:.|||||
  Rat   308 KAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYN 372

  Fly   391 RTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEKGL 455
            :|||||..||.::||||:.:|||:||||||:|||||||||||||.|||.:|.||.:||:.:|..:
  Rat   373 KTNKFTHGFQNIVDAYGIGTYREINPAPYTVITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRI 437

  Fly   456 AAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL-------SYNKSTV 513
            .:||.:||::::.|.|||||.|||:||:||||||||.||||||||||.|.:       ::.:.|:
  Rat   438 LSQKNENEMFSMVFSGRYIILLMGLFSIYTGLIYNDCFSKSLNIFGSSWSVRPMFTIGNWTEETL 502

  Fly   514 MENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWH 576
            :.:..|||:|  .|.: |.|||||:||||.:| .||:.|.|::|||:|:|.|:|||:|||.:|..
  Rat   503 LGSSVLQLNPAIPGVF-GGPYPFGIDPIWNIA-TNKLTFLNSFKMKMSVILGIIHMLFGVSLSLF 565

  Fly   577 NHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDMVL 641
            ||.||:..:::.:.|||:::|:..||.|:|:|:|.||..:.|     :|...|||:||.||:|.|
  Rat   566 NHIYFKKPLNIYFGFIPEIIFMSSLFGYLVILIFYKWTAYDA-----HSSRNAPSLLIHFINMFL 625

  Fly   642 FNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQ---ARKQANVQPIAGATS 703
            |:.    ||:....::.||..||...::||:.|:|.|||.|||::..   .:|....||:....:
  Rat   626 FSY----PESGNAMLYSGQKGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLEGQPVEAPVT 686

  Fly   704 DAEA-----------GGVSNSGSHGGGGGHEEEEEL------------------SEIF------I 733
            .|.:           |.::..|...|.|..||:.|:                  .|:|      :
  Rat   687 PAPSQQGLEAAPAATGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDAEEPTEDEVFDFGDTMV 751

  Fly   734 HQSIHTIEYVLGSVSHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWA 798
            ||:||||||.||.:|:|||||||||||||||||:|||||||:.|||......||:.|..:||.:|
  Rat   752 HQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLHVRSLAGGLGLFFIFAAFA 816

  Fly   799 ILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAIIE 847
            .|||.||::|||||||||.|||||||||:|||.|.|:.|.||||:.|.|
  Rat   817 TLTVAILLIMEGLSAFLHALRLHWVEFQNKFYTGTGFKFLPFSFEHIRE 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	496/861 (58%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	495/860 (58%)
Atp6v0a1	XP_017452683.1	V_ATPase_I	27..860	CDD:396194	496/861 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342350
Domainoid	1	1.000	945	1.000	Domainoid score	I32
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3795
Inparanoid	1	1.050	1000	1.000	Inparanoid score	I282
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		otm45697
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	LDO	PTHR11629
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810