Protein Alignment Vha100-1 and Atp6v0a4

DIOPT Version :10

• Sequence 1: NP_651672.1
• Gene: Vha100-1 / 43442
• FlyBaseID: FBgn0028671
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001402767.1
• Gene: Atp6v0a4 / 296981
• RGDID: 1305055
• Length: 829
• Species: Rattus norvegicus
• Alignment Length: 876
• Identity: 465/876 - (53%)
• Similarity: 613/876 - (69%)
• Gaps: 68/876 - (7%)

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |.|:||||||.|.|:|||.||||.||:||||||||||:|||.:||:||||||||||||:.:||.|
  Rat     1 MASVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLERIL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            |:||.|::.:.|..: ..:.|..|.|||||.||.|.||||.||:|.||:.:|||::||||||||:
  Rat    66 RFLEDEMQNEIIIQV-PDKDPGTPLPREMITLETTLEKLEGELQEANQSHQALKKSFLELTELKY 129

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNED----EQAQLLGEEGVRASQPGQNL 191
            :|:|||.||:...                       |..||    :.:.||....:.|...|
  Rat   130 LLKKTQDFFETET-----------------------NLGEDFFVEDTSGLLELRAMPAFMTG--- 168

  Fly   192 KLGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKT 256
            ||||.||||.|||:.:|||:|||.|||||:|:.:.::|.||||...:::.|::||||:||:||:.
  Rat   169 KLGFTAGVINRERMASFERLLWRVCRGNVYLKFSEMDTLLEDPVTKEEIKKNIFIIFYQGEQLRL 233

  Fly   257 RVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVK 321
            ::||||:|||||:|||||..|:||||...|..|:|||.||:.||:.||.|:|..||.|..:|.:|
  Rat   234 KIKKICDGFRATIYPCPEHAAERREMLASVNVRLEDLITVITQTESHRQRLLQEAASNWHSWVIK 298

  Fly   322 VRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENP 386
            |:|:||:||.||:.|:||||:|:|||.|.|:.|...|:.||.:|.|.||||:.||:..::|..:|
  Rat   299 VQKMKAVYHVLNMCNIDVTQQCIIAEIWFPVADTRHIKKALEQGMELSGSSMVPIMTEVETKTDP 363

  Fly   387 PTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRK 451
            ||:|||||||..||.::|||||.||||:||||||||||||||||||||.|||.:|.:..|||:..
  Rat   364 PTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGMVMLMAALWMVLN 428

  Fly   452 EKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL-------SYN 509
            |:.|.|||:.||:|||||.|||:|.|||:||:||||||||.||||.|||||.|.:       ::|
  Rat   429 ERHLLAQKSTNEMWNIFFNGRYLILLMGIFSIYTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWN 493

  Fly   510 KSTVMENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVV 572
            ...|.:|.:|||.|  .|.|.|.|||||:||||.:| :||:.|.|:||||:|:|.|::||||||:
  Rat   494 AHVVEQNPYLQLDPAIPGVYSGNPYPFGIDPIWNLA-SNKLTFLNSYKMKMSVILGIVHMIFGVI 557

  Fly   573 MSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKF-AATNDKPYSEACAPSILITF 636
            :|..||.|||..::::.:|||:::|:|.||.|:|.::..||.:: |.|:.|      ||||||.|
  Rat   558 LSLFNHIYFRRTLNIILQFIPEMIFMLSLFGYLVFMIIFKWCQYDAHTSQK------APSILIHF 616

  Fly   637 IDMVLF------NTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQANV 695
            |.|.||      |.|          ::..|..:|..||::|:..:|.|||.||.::....:::.:
  Rat   617 IGMFLFDYDDSSNAP----------LYGHQQEVQTFFVIIALVSVPWMLLIKPFILRAKHQKSQL 671

  Fly   696 QPIAGATSDAEAGGV-SNSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASYLRLWAL 759
            |.........|...| ..:|:||...|||||....:||:||:||||||.||.:|:||||||||||
  Rat   672 QSFTIHEDAMEGPSVKKTAGAHGTKEGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLWAL 736

  Fly   760 SLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWVE 824
            |||||:|:|||||||:||||:..|..|.:.:..:||.:|:|||.||::|||||||||.|||||||
  Rat   737 SLAHAELSEVLWTMVMSIGLRLRGWGGLVGVFIIFAVFAVLTVAILLVMEGLSAFLHALRLHWVE 801

  Fly   825 FQSKFYKGQGYAFQPFSFDAIIENGAAAAEE 855
            ||:|||:|.|:.|.||||..::|   .||||
  Rat   802 FQNKFYEGAGFKFSPFSFKHVLE---GAAEE 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	V_ATPase_I	27..842	CDD:460232	439/835 (53%)
Atp6v0a4	NP_001402767.1	V_ATPase_I	27..819	CDD:460232	439/835 (53%)