DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-1 and Atp6v0a4

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_006236358.1	Gene:	Atp6v0a4 / 296981	RGDID:	1305055	Length:	829	Species:	Rattus norvegicus

Alignment Length:	876	Identity:	465/876 - (53%)
Similarity:	613/876 - (69%)	Gaps:	68/876 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |.|:||||||.|.|:|||.||||.||:||||||||||:|||.:||:||||||||||||:.:||.|
  Rat     1 MASVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLERIL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            |:||.|::.:.|..: ..:.|..|.|||||.||.|.||||.||:|.||:.:|||::||||||||:
  Rat    66 RFLEDEMQNEIIIQV-PDKDPGTPLPREMITLETTLEKLEGELQEANQSHQALKKSFLELTELKY 129

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNED----EQAQLLGEEGVRASQPGQNL 191
            :|:|||.||:...                       |..||    :.:.||....:.|...|
  Rat   130 LLKKTQDFFETET-----------------------NLGEDFFVEDTSGLLELRAMPAFMTG--- 168

  Fly   192 KLGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKT 256
            ||||.||||.|||:.:|||:|||.|||||:|:.:.::|.||||...:::.|::||||:||:||:.
  Rat   169 KLGFTAGVINRERMASFERLLWRVCRGNVYLKFSEMDTLLEDPVTKEEIKKNIFIIFYQGEQLRL 233

  Fly   257 RVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVK 321
            ::||||:|||||:|||||..|:||||...|..|:|||.||:.||:.||.|:|..||.|..:|.:|
  Rat   234 KIKKICDGFRATIYPCPEHAAERREMLASVNVRLEDLITVITQTESHRQRLLQEAASNWHSWVIK 298

  Fly   322 VRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENP 386
            |:|:||:||.||:.|:||||:|:|||.|.|:.|...|:.||.:|.|.||||:.||:..::|..:|
  Rat   299 VQKMKAVYHVLNMCNIDVTQQCIIAEIWFPVADTRHIKKALEQGMELSGSSMVPIMTEVETKTDP 363

  Fly   387 PTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRK 451
            ||:|||||||..||.::|||||.||||:||||||||||||||||||||.|||.:|.:..|||:..
  Rat   364 PTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGMVMLMAALWMVLN 428

  Fly   452 EKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL-------SYN 509
            |:.|.|||:.||:|||||.|||:|.|||:||:||||||||.||||.|||||.|.:       ::|
  Rat   429 ERHLLAQKSTNEMWNIFFNGRYLILLMGIFSIYTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWN 493

  Fly   510 KSTVMENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVV 572
            ...|.:|.:|||.|  .|.|.|.|||||:||||.:| :||:.|.|:||||:|:|.|::||||||:
  Rat   494 AHVVEQNPYLQLDPAIPGVYSGNPYPFGIDPIWNLA-SNKLTFLNSYKMKMSVILGIVHMIFGVI 557

  Fly   573 MSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKF-AATNDKPYSEACAPSILITF 636
            :|..||.|||..::::.:|||:::|:|.||.|:|.::..||.:: |.|:.|      ||||||.|
  Rat   558 LSLFNHIYFRRTLNIILQFIPEMIFMLSLFGYLVFMIIFKWCQYDAHTSQK------APSILIHF 616

  Fly   637 IDMVLF------NTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQANV 695
            |.|.||      |.|          ::..|..:|..||::|:..:|.|||.||.::....:::.:
  Rat   617 IGMFLFDYDDSSNAP----------LYGHQQEVQTFFVIIALVSVPWMLLIKPFILRAKHQKSQL 671

  Fly   696 QPIAGATSDAEAGGV-SNSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASYLRLWAL 759
            |.........|...| ..:|:||...|||||....:||:||:||||||.||.:|:||||||||||
  Rat   672 QSFTIHEDAMEGPSVKKTAGAHGTKEGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLWAL 736

  Fly   760 SLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWVE 824
            |||||:|:|||||||:||||:..|..|.:.:..:||.:|:|||.||::|||||||||.|||||||
  Rat   737 SLAHAELSEVLWTMVMSIGLRLRGWGGLVGVFIIFAVFAVLTVAILLVMEGLSAFLHALRLHWVE 801

  Fly   825 FQSKFYKGQGYAFQPFSFDAIIENGAAAAEE 855
            ||:|||:|.|:.|.||||..::|   .||||
  Rat   802 FQNKFYEGAGFKFSPFSFKHVLE---GAAEE 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	439/835 (53%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	439/834 (53%)
Atp6v0a4	XP_006236358.1	NtpI	28..820	CDD:224188	440/835 (53%)
Atp6v0a4	XP_006236358.1	V_ATPase_I	28..819	CDD:279793	439/834 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	945	1.000	Domainoid score	I32
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1000	1.000	Inparanoid score	I282
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		otm45697
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.880