DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-1 and Tcirg1

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_954520.2	Gene:	Tcirg1 / 293650	RGDID:	735136	Length:	834	Species:	Rattus norvegicus

Alignment Length:	875	Identity:	384/875 - (43%)
Similarity:	534/875 - (61%)	Gaps:	79/875 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |||:|||||:||.||.|.:.:||.|||:|||||||:|||||..|:||||:||.|||||:|:|:..
  Rat     1 MGSMFRSEEVALVQLLLPTASAYNCVSQLGELGLVEFRDLNESVSAFQRRFVVEVRRCEELEKTF 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            .:|.:|:::.|:.:.....:..||.||:::.::...::|..|||:|..|.:||:....:|.....
  Rat    66 TFLREEVQRAGLTLTPPEGTLPAPPPRDLLRIQEETDRLAQELRDVRGNQQALRAQLHQLQLHSA 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNE---DEQAQLLGEEGVRASQPG--QN 190
            :|.::..                        |.||....|   .|:..||      ::.||  .:
  Rat   131 VLGQSHA------------------------PPMAAVHTEGPTTERTPLL------SATPGPHAD 165

  Fly   191 LKLGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIET--PLEDPTNGDQVHKSVFIIFFQGDQ 253
            ||:.||||.:...:..|.||:|||||||  ||..:..||  .||||..|:......|:|.:.|:|
  Rat   166 LKVNFVAGAVEPCKAAALERLLWRACRG--FLIASFKETEGQLEDPVTGEPATWMTFVISYWGEQ 228

  Fly   254 LKTRVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNW 318
            :..:|:||.:.|...::|..|....|......:..:.::|..|||:|:....:||....:.|...
  Rat   229 IGQKVRKITDCFHCHVFPYLEQEEARLRTLQQLQQQSQELQEVLGETERFLSQVLGRVQQLLPPG 293

  Fly   319 FVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTF 383
            .|::||:||::.|||..:::.|.||||||.|....|:.|:|.||:.|:...|  |..:.:|:...
  Rat   294 QVQIRKMKAVHLTLNQCSVNTTHKCLIAEVWCATRDLPTVQQALQSGSSEEG--VSAVAHRIPCQ 356

  Fly   384 ENPPTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWM 448
            :.|||..|||:||.:||.::|||||..|||:||||||||||||||||||||:|||.:|.||.|.|
  Rat   357 DMPPTLIRTNRFTSSFQGIVDAYGVGRYREVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAM 421

  Fly   449 IRKEKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLS------ 507
            :..|...|.:.|.||||..||||||:..|||:||:|||.|||:.||::..||.|.|.::
  Rat   422 VLTENQPAVKTTQNEIWQTFFGGRYLPLLMGLFSIYTGFIYNECFSRATTIFPSGWSVAAMANQS 486

  Fly   508 -YNKSTVMENKFLQLSPK--GDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIF 569
             ::...:.::..|.|:|.  |.:.| |||||:||||.:| .|.:.|.|::|||:|:|.||.||.|
  Rat   487 GWSDEYLSQHPMLTLNPNITGVFLG-PYPFGIDPIWSLA-TNHLSFLNSFKMKMSVILGVTHMAF 549

  Fly   570 GVVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILI 634
            ||.:|..||.:|.....||.|.:|:|:|||.||.|:|.|:..||:..:|.     |.:.||||||
  Rat   550 GVFLSIFNHVHFGQAHRLLLETVPELIFLLGLFGYLVFLIVYKWLYVSAA-----SASSAPSILI 609

  Fly   635 TFIDMVLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQANVQ--P 697
            .||:|.||:   ..|.|  ..:|.||..:|...|::|:..:|::||..||.:::...:.|.|  |
  Rat   610 HFINMFLFS---QNPTN--RLLFHGQVVVQYALVVLALATVPILLLGTPLYLLRQHHRRNTQRRP 669

  Fly   698 IAGATSD--------AEAGGVSNSGS----HGGGGGHEEEEEL-SEIFIHQSIHTIEYVLGSVSH 749
            .||...:        .:|..:.||.|    ..|..|.||.|.: ||||:||:|||||:.||.:|:
  Rat   670 TAGRQDEDSDKLLASPDASTLENSWSPDEEKAGSSGDEEAEFVPSEIFMHQAIHTIEFCLGCISN 734

  Fly   750 TASYLRLWALSLAHAQLAEVLWTMVLSIGL--KQEGPVGGIVLTCVFAFWAILTVGILVLMEGLS 812
            |||||||||||||||||:||||.||:.|||  .:|..|..:||..|||.:|:|||.||::|||||
  Rat   735 TASYLRLWALSLAHAQLSEVLWAMVMRIGLGMGREIGVASVVLVPVFAAFAVLTVAILLVMEGLS 799

  Fly   813 AFLHTLRLHWVEFQSKFYKGQGYAFQPFSF 842
            ||||.|||||||||:|||.|.||...||:|
  Rat   800 AFLHALRLHWVEFQNKFYSGTGYKLSPFAF 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	366/847 (43%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	365/846 (43%)
Tcirg1	NP_954520.2	NtpI	27..829	CDD:224188	366/847 (43%)
Tcirg1	NP_954520.2	V_ATPase_I	28..829	CDD:279793	365/846 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830