Protein Alignment Vha100-1 and Tcirg1

DIOPT Version :10

• Sequence 1: NP_651672.1
• Gene: Vha100-1 / 43442
• FlyBaseID: FBgn0028671
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_954520.3
• Gene: Tcirg1 / 293650
• RGDID: 735136
• Length: 834
• Species: Rattus norvegicus
• Alignment Length: 875
• Identity: 385/875 - (44%)
• Similarity: 535/875 - (61%)
• Gaps: 79/875 - (9%)

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |||:|||||:||.||.|.:.:||.|||:|||||||:|||||..|:||||:||.|||||:|:|:..
  Rat     1 MGSMFRSEEVALVQLLLPTASAYNCVSQLGELGLVEFRDLNESVSAFQRRFVVEVRRCEELEKTF 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            .:|.:|:::.|:.:.....:..||.||:::.::...::|..|||:|..|.:||:....:|.....
  Rat    66 TFLREEVQRAGLTLTPPEGTLPAPPPRDLLRIQEETDRLAQELRDVRGNQQALRAQLHQLQLHSA 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNE---DEQAQLLGEEGVRASQPG--QN 190
            :|.::..                        |.||....|   .|:..||      ::.||  .:
  Rat   131 VLGQSHA------------------------PPMAAVHTEGPTTERTPLL------SATPGPHAD 165

  Fly   191 LKLGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIET--PLEDPTNGDQVHKSVFIIFFQGDQ 253
            ||:.||||.:...:..|.||:|||||||  ||..:..||  .||||..|:......|:|.:.|:|
  Rat   166 LKVNFVAGAVEPCKAAALERLLWRACRG--FLIASFKETEGQLEDPVTGEPATWMTFVISYWGEQ 228

  Fly   254 LKTRVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNW 318
            :..:|:||.:.|...::|..|....|......:..:.::|..|||:|:....:||....:.|...
  Rat   229 IGQKVRKITDCFHCHVFPYLEQEEARLRTLQQLQQQSQELQEVLGETERFLSQVLGRVQQLLPPG 293

  Fly   319 FVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTF 383
            .|::||:||:|.|||..:::.|.||||||.|....|:.|:|.||:.|:...|  |..:.:|:...
  Rat   294 QVQIRKMKAVYLTLNQCSVNTTHKCLIAEVWCATRDLPTVQQALQSGSSEEG--VSAVAHRIPCQ 356

  Fly   384 ENPPTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWM 448
            :.|||..|||:||.:||.::|||||..|||:||||||||||||||||||||:|||.:|.||.|.|
  Rat   357 DMPPTLIRTNRFTSSFQGIVDAYGVGRYREVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAM 421

  Fly   449 IRKEKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLS------ 507
            :..|...|.:.|.||||..||||||::.|||:||:|||.|||:.||::..||.|.|.::
  Rat   422 VLTENQPAVKTTQNEIWQTFFGGRYLLLLMGLFSIYTGFIYNECFSRATTIFPSGWSVAAMANQS 486

  Fly   508 -YNKSTVMENKFLQLSPK--GDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIF 569
             ::...:.::..|.|:|.  |.:.| |||||:||||.:| .|.:.|.|::|||:|:|.||.||.|
  Rat   487 GWSDEYLSQHPMLTLNPNITGVFLG-PYPFGIDPIWSLA-TNHLSFLNSFKMKMSVILGVTHMAF 549

  Fly   570 GVVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILI 634
            ||.:|..||.:|.....||.|.:|:|:|||.||.|:|.|:..||:..:|.     |.:.||||||
  Rat   550 GVFLSIFNHVHFGQAHRLLLETVPELIFLLGLFGYLVFLIVYKWLYVSAA-----SASSAPSILI 609

  Fly   635 TFIDMVLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQANVQ--P 697
            .||:|.||:   ..|.|  ..:|.||..:|...|::|:..:|::||..||.:::...:.|.|  |
  Rat   610 HFINMFLFS---QNPTN--RLLFHGQVVVQYALVVLALATVPILLLGTPLYLLRQHHRRNTQRRP 669

  Fly   698 IAGATSD--------AEAGGVSNSGS----HGGGGGHEEEEEL-SEIFIHQSIHTIEYVLGSVSH 749
            .||...:        .:|..:.||.|    ..|..|.||.|.: ||||:||:|||||:.||.:|:
  Rat   670 TAGRQDEDSDKLLASPDASTLENSWSPDEEKAGSSGDEEAEFVPSEIFMHQAIHTIEFCLGCISN 734

  Fly   750 TASYLRLWALSLAHAQLAEVLWTMVLSIGL--KQEGPVGGIVLTCVFAFWAILTVGILVLMEGLS 812
            |||||||||||||||||:||||.||:.|||  .:|..|..:||..|||.:|:|||.||::|||||
  Rat   735 TASYLRLWALSLAHAQLSEVLWAMVMRIGLGMGREIGVASVVLVPVFAAFAVLTVAILLVMEGLS 799

  Fly   813 AFLHTLRLHWVEFQSKFYKGQGYAFQPFSF 842
            ||||.|||||||||:|||.|.||...||:|
  Rat   800 AFLHALRLHWVEFQNKFYSGTGYKLSPFAF 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	V_ATPase_I	27..842	CDD:460232	367/847 (43%)
Tcirg1	NP_954520.3	V_ATPase_I	27..829	CDD:460232	367/847 (43%)