DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-1 and Atp6v0a2

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_035726.2	Gene:	Atp6v0a2 / 21871	MGIID:	104855	Length:	856	Species:	Mus musculus

Alignment Length:	884	Identity:	405/884 - (45%)
Similarity:	563/884 - (63%)	Gaps:	78/884 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            ||||||||.|.|.||||||..||.|:|.|||.|||||||||.:|::||||||.||:||:|:||.|
Mouse     1 MGSLFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERIL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            .||.:||.:..||:.:...||.||..:.:::::...:|||.|||||.:|.|.|::|.|||.|..|
Mouse    66 VYLVQEITRADIPLPEGEASPPAPPLKHVLEMQEQLQKLEVELREVTKNKEKLRKNLLELVEYTH 130

  Fly   131 ILRKTQVFFDESV---PTVYKSSGAYSSSKYRRYPQMADNQNEDEQA-QLLGEEGVRASQPGQNL 191
            :||.|:.|...:|   ||            |..:|.:.::...|... |.||            .
Mouse   131 MLRVTKTFLKRNVEFEPT------------YEEFPALENDSLLDYSCMQRLG------------A 171

  Fly   192 KLGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKT 256
            |||||:|:|.:.|:.||||||||||:|...:..|.::..||||..|:.:...||:|.|.|:|:..
Mouse   172 KLGFVSGLIQQGRVEAFERMLWRACKGYTIVTYAELDECLEDPETGEVIKWYVFLISFWGEQIGH 236

  Fly   257 RVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVK 321
            :|||||:.:...:||.|....:|||:..|:.|||:||.|||.:|:|:..:||..||:::.:..|:
Mouse   237 KVKKICDCYHCHIYPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVCSRVVQ 301

  Fly   322 VRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENP 386
            |||:|||||.||:.:.|||.||||||.|.|.:|:..::.||..|:..||:::|..:|.:.|.|.|
Mouse   302 VRKMKAIYHMLNMCSFDVTNKCLIAEVWCPEVDLPGLRRALEEGSRESGATIPSFMNTIPTKETP 366

  Fly   387 PTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRK 451
            ||..||||||:.||.::|||||.||||:|||.:|||||||||||||||.|||.:|.||.|.::..
Mouse   367 PTLIRTNKFTEGFQNIVDAYGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLN 431

  Fly   452 EKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLS--------- 507
            |......:: .||..:||.||||:.|||:||:||||||||.||||:|:|||.|::|
Mouse   432 ENHPRLSQS-QEILRMFFDGRYILLLMGLFSVYTGLIYNDCFSKSVNLFGSGWNVSAMYSSSHSP 495

  Fly   508 --------YNKSTVMENKFLQLSPK--GDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIF 562
                    :|.||:..::.|||.|.  |.:.| |||||:||||.:| .|::.|.|::|||:|:|.
Mouse   496 EEQRKMVLWNDSTIRHSRTLQLDPNIPGVFRG-PYPFGIDPIWNLA-TNRLTFLNSFKMKMSVIL 558

  Fly   563 GVIHMIFGVVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEA 627
            |:.||.||||:...||.:||.:.::....:|:::|:|.:|.|::.::..||:.::|...:.
Mouse   559 GIFHMTFGVVLGIFNHLHFRKKFNVYLVSVPEILFMLCIFGYLIFMIIYKWLAYSAETSRE---- 619

  Fly   628 CAPSILITFIDMVLFNTPKPPPENCETY-MFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARK 691
             ||||||.||:|.||.|.|       |: ::.||..:|.:.|.:.|..:||:.|.|||.::....
Mouse   620 -APSILIEFINMFLFPTSK-------THGLYPGQAHVQRVLVALTVLAVPVLFLGKPLFLLWLHN 676

  Fly   692 QANV--QPIAGAT-----SDAEAGGVSNSGSHGGGGGHE--------EEEELSEIFIHQSIHTIE 741
            ..|.  ...:|.|     |:.|...:.|.....|....|        ||....||.:.|:||:||
Mouse   677 GRNCFGMSRSGYTLVRKDSEEEVSLLGNQDIEEGNSRMEEGCREVTCEEFNFGEILMTQAIHSIE 741

  Fly   742 YVLGSVSHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILV 806
            |.||.:|:|||||||||||||||||::|||.|::.:||:.:...|.::|..|.||:|:||:.||:
Mouse   742 YCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVMAFFAVLTIFILL 806

  Fly   807 LMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAI 845
            :|||||||||.:||||||||:|||.|.|..|.||||..:
Mouse   807 VMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLL 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	384/853 (45%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	383/852 (45%)
Atp6v0a2	NP_035726.2	NtpI	5..839	CDD:224188	397/872 (46%)
Atp6v0a2	NP_035726.2	V_ATPase_I	28..839	CDD:279793	381/849 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820