Protein Alignment Vha100-1 and vha-7

DIOPT Version :10

• Sequence 1: NP_651672.1
• Gene: Vha100-1 / 43442
• FlyBaseID: FBgn0028671
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001379486.1
• Gene: vha-7 / 178219
• WormBaseID: WBGene00006916
• Length: 1210
• Species: Caenorhabditis elegans
• Alignment Length: 917
• Identity: 368/917 - (40%)
• Similarity: 533/917 - (58%)
• Gaps: 76/917 - (8%)

  Fly     3 SLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKLRY 67
            |:|||:.|.|.|:.|..|||:.||:|:|:.|.|||.|||..::.:.|.||.::|||:|||||||:
 Worm   291 SMFRSDPMKLYQMILVKEAAFECVAEIGKHGNVQFVDLNAKMSLYSRTFVKQMRRCEEMERKLRF 355

  Fly    68 LEKEI--KKDGI-PMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELK 129
            |||::  .|.|: |.........||...|||.||...::||.|..::|.|..||::|.....|..
 Worm   356 LEKQVITCKPGLDPKSIDYTDLSAPTQAEMIQLEHKLDQLEREFLDLNNNDYALRKNLNSSKEFL 420

  Fly   130 HILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQP------- 187
            .::|....||.     |:|...|.:     |:.:.|...:.:..::..|..|:.:|..
 Worm   421 QVMRLVDEFFQ-----VHKEEEAKA-----RFERSATTDDIEMFSKSFGFGGLPSSNEMPLTPLL 475

  Fly   188 GQNLKLGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGD 252
            |.:....|||||:..::..:|||:||||||...|:|.:.....:.||...:.:.|.|||:||:|:
 Worm   476 GSDDNAWFVAGVLPLDKKESFERVLWRACRRTAFVRTSDASFTVNDPVTLEPLQKCVFIVFFKGE 540

  Fly   253 QLKTRVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKN 317
            .|:..|:|:|:||.||.||||::..||:........|:.||..|:..||.||:.:|...:..:..
 Worm   541 SLRLIVEKVCDGFNATQYPCPKSSKDRKMKMSETEGRMNDLTVVIDTTQTHRYTILKDMSFEIPI 605

  Fly   318 WFVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQT 382
            |...::..|:::..:|:|.:| |...|..|||:|..:.:.::.||..|.:.||:.|.||||.:.|
 Worm   606 WLKNIQIQKSVFAVMNMFTVD-TNGFLAGECWIPAAEEDDVRQALHDGFKASGTEVEPILNELWT 669

  Fly   383 FENPPTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLW 447
            ...|||::||||||..||:::|:|||:.|.|:||||||||||||||||||||..||||:.|..|:
 Worm   670 NAPPPTFHRTNKFTNVFQSIVDSYGVSQYCEVNPAPYTIITFPFLFAVMFGDAAHGAILLLAALF 734

  Fly   448 MIRKEKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLSYNKST 512
            .||.|:.:.::|..:||:|.|:|||||:.|||:||:|||.:|||.|:||.|:|||.|..|||::.
 Worm   735 FIRNERKIESKKIRDEIFNTFYGGRYIMMLMGIFSIYTGFLYNDAFAKSFNVFGSGWSNSYNETQ 799

  Fly   513 V----------MENKFLQLSPKGDYE-GAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIH 566
            :          .....|:|.|:..:: ...||||:||||.:|. |::.|.|:.|||.|:|.|:..
 Worm   800 LDWWIARSYRKHREYSLELVPEKSFDIEKTYPFGVDPIWNIAD-NRLSFLNSMKMKASVIIGITQ 863

  Fly   567 MIFGVVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPY-----SE 626
            |.|||.:|..||.:|::.|.::..||||::||..:|.|:.:.:.:|||.|:...:..:     ..
 Worm   864 MTFGVFLSVLNHIHFKSYIDIISNFIPQVIFLSCIFIYLCIQIIVKWIFFSVNAENVFGFEYPGS 928

  Fly   627 ACAPSILITFIDMVLF--------NTPKPPPENCET-YMFMGQHFIQVLFVLVAVGCIPVMLLAK 682
            .||||:||..|:|.:|        |.......||.. |.:..|..::.:.:.:::.|||:||..|
 Worm   929 HCAPSLLIGLINMFMFKKRNEGYLNENGEVYSNCHLGYWYPNQRLVETILISISLACIPIMLFGK 993

  Fly   683 PLLI---------MQARKQANVQPIAGATSDAEAGGVSNSG-----------SHGGGGGHEEEEE 727
            ||.:         :|..|........|.|..|....|.::|           :.....|.:....
 Worm   994 PLWVRFVTSKRHKLQENKSLKSLRRNGTTVSAPTSPVVDAGPPRFEDAELLLADELDIGEDIHHS 1058

  Fly   728 LSEIFIHQSIHTIEYVLGSVSHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGG----- 787
            ||:||:||:|||||:|||.||||||||||||||||||||:||:|.|||..|:.....:..
 Worm  1059 LSDIFVHQAIHTIEFVLGCVSHTASYLRLWALSLAHAQLSEVMWHMVLIQGIHTVDHIENETIAM 1123

  Fly   788 ---IVLTCV-FAFWAILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAIIEN 848
               .|:.|| |..:|.|::.||::|||||||||.|||||||||||||.|.|:.|..|.....:||
 Worm  1124 CLKPVVACVAFFIFASLSLSILIMMEGLSAFLHALRLHWVEFQSKFYLGTGHPFHAFYLKESLEN 1188

  Fly   849 GAAAAEE 855
            .....||
 Worm  1189 AQLITEE 1195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	V_ATPase_I	27..842	CDD:460232	351/878 (40%)
vha-7	NP_001379486.1	V_ATPase_I	315..1181	CDD:460232	350/877 (40%)