Protein Alignment Vha100-1 and vha-5

DIOPT Version :10

• Sequence 1: NP_651672.1
• Gene: Vha100-1 / 43442
• FlyBaseID: FBgn0028671
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_501399.1
• Gene: vha-5 / 177626
• WormBaseID: WBGene00006914
• Length: 873
• Species: Caenorhabditis elegans
• Alignment Length: 904
• Identity: 422/904 - (46%)
• Similarity: 574/904 - (63%)
• Gaps: 83/904 - (9%)

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            ||||.|||||..|||.::.:||:..|:|:|:...|||:||||:||:|||.||.::||.|||||||
 Worm     1 MGSLSRSEEMRFCQLIVEKDAAFNIVAEIGKQPYVQFKDLNPNVNSFQRTFVKDIRRYDEMERKL 65

  Fly    66 RYLEKEIKKDGIPM---LDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTE 127
            |:||.:|.||.|.:   :|||:....| ..|:..||.|..:||.:::.:|.:...||.||::|.|
 Worm    66 RFLESQIVKDEIVIPGRVDTGDYTILP-TSELNTLEGTLTELEKDVKSMNDSDSQLKANFMDLKE 129

  Fly   128 LKHILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLK 192
            ...:|.||..||...|                      |:|.::|...|..|..|...:.|   .
 Worm   130 WDAVLDKTDEFFQGGV----------------------DDQAQEELENLDEEGAVPRVEKG---P 169

  Fly   193 LGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTR 257
            :.::.|:|.||||..|||:|||||....::|.:.||..||||..|::|||||||||.:||::::.
 Worm   170 VNYLVGIIRRERLNGFERVLWRACHHTAYIRSSDIEEELEDPGTGEKVHKSVFIIFLKGDRMRSI 234

  Fly   258 VKKICEGFRATLYP-CPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVK 321
            |:|:|:||:|.|:. ||:...:|:.....|..||:||.||||||::||.|||.|||.|...|..:
 Worm   235 VEKVCDGFKAKLFKNCPKTFKERQSARNDVRARIQDLQTVLGQTREHRFRVLQAAANNHHQWLKQ 299

  Fly   322 VRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENP 386
            ||.||.::|.||||..|...:..:.|||:||..:|.::.|:..|.|||||||.|:||.::|...|
 Worm   300 VRMIKTVFHMLNLFTFDGIGRFFVGECWIPLKHVEDVRKAIEVGAERSGSSVKPVLNILETSVTP 364

  Fly   387 PTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRK 451
            ||||.|||||..||.::|:||:|:|||:||||||||||||||:.||||||||.||.:.|||.:.:
 Worm   365 PTYNETNKFTAVFQGIVDSYGIATYRELNPAPYTIITFPFLFSCMFGDLGHGCIMLMAGLWFVLR 429

  Fly   452 EKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLSYNKSTVM-- 514
            ||.|.|:...:||:|:||||||||.|||:||::.|:||||:|:||.|||||.|...||.|.:.
 Worm   430 EKNLQARNIKDEIFNMFFGGRYIILLMGLFSIHAGIIYNDMFAKSFNIFGSGWKNPYNASEIEGW 494

  Fly   515 -------ENKFLQLSPKG--DYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFG 570
                   :...::|:|:.  |:.|.||.||:||||.:| .||:.|.|:.|||:|:|.|:..|.||
 Worm   495 INRTEHGKEMLVELAPEDAYDHAGGPYSFGVDPIWNIA-ENKLNFLNSMKMKLSVILGISQMTFG 558

  Fly   571 VVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEA-----CAP 630
            |::|:.||||.:::|.:...||||::|:..:|.|:.|.:.:||:.|.......:.:.     |||
 Worm   559 VILSFFNHTYNKSKIDIFTVFIPQMLFMGCIFMYLCLQIILKWLFFWTKEATVFGQIYPGSHCAP 623

  Fly   631 SILITFIDMVLF--------------NTPKPPPENCETYM---FMGQHFIQVLFVLVAVGCIPVM 678
            |:||..|:|.:.              |......|.|  |:   :.||..|:::.|::||.|:|||
 Worm   624 SLLIGLINMFMMKDRNAGFVVDGGKVNGEYREVETC--YLSQWYPGQSVIEMILVVIAVICVPVM 686

  Fly   679 LLAKPL-LIMQARKQA-----NVQPIAGATSDAEA----GGVSNSGS----HGGGGGHEEEEELS 729
            |..||: .:||.:|:|     |....|...||:..    ||....|:    ||.||  .|:|...
 Worm   687 LFGKPIHHVMQQKKKAKELHGNATVRANVVSDSSEIVLNGGSKKEGAAHEEHGHGG--HEDESFG 749

  Fly   730 EIFIHQSIHTIEYVLGSVSHTASYLRLWALSLAHAQLAEVLWTMV-LSIGLKQEGPVGGIVLTCV 793
            :|.:||:|||||||||.||||||||||||||||||||:||||.|| ::.||...|..|.|.:..|
 Worm   750 DIMVHQAIHTIEYVLGCVSHTASYLRLWALSLAHAQLSEVLWHMVFVTGGLGISGTAGFIAVYVV 814

  Fly   794 FAFWAILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAIIENGAAA 852
            |..:.:||:.|||||||||||||||||||||||||||.|.||.|.|:||...::...||
 Worm   815 FFIFFVLTISILVLMEGLSAFLHTLRLHWVEFQSKFYLGLGYPFVPYSFKTALQEAEAA 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	V_ATPase_I	27..842	CDD:460232	403/866 (47%)
vha-5	NP_501399.1	V_ATPase_I	27..863	CDD:460232	403/866 (47%)