DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-1 and vha-6

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_496436.1	Gene:	vha-6 / 174743	WormBaseID:	WBGene00006915	Length:	865	Species:	Caenorhabditis elegans

Alignment Length:	909	Identity:	406/909 - (44%)
Similarity:	548/909 - (60%)	Gaps:	115/909 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |||::|||.|.|||:|.|||:||.||:||||||:.||.|||.:.||:.||||||||||||||||:
Worm     1 MGSIYRSEHMKLCQIFFQSESAYQCVAELGELGMAQFIDLNEEQNAYTRKFVNEVRRCDEMERKI 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            .::|.||.||.:|:.|..|...||||:.|.::||..||||.||.::|:|.:.||.|.::|.|:|.
Worm    66 NFVEDEITKDLVPIPDYDEHIPAPQPKHMGEMEANLEKLEEELVQINKNCKVLKNNHVQLLEMKA 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGV-------RASQPG 188
            :|.......|..    .|...|.|.|:..|                 ||.|.       ...:|.
Worm   131 VLEHVTSLLDPH----SKREAAMSISEAAR-----------------GEAGPISFGMKDEFDKPV 174

  Fly   189 QNLK-LGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGD 252
            ::.| |.||.||:.|.:..||||.|||..|..||.:...|:...|..:| :...|.|||:||.|:
Worm   175 KDEKELKFVTGVVKRSKAIAFERFLWRLSRAKVFAKFIQIQEQTELFSN-EFEDKCVFILFFSGE 238

  Fly   253 QLKTRVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKN 317
            ||:.:|||||:||:|..|..||.||:|.::.:.:..:..|:..|:.:|.|:|.:.:.|||.||:.
Worm   239 QLRAKVKKICDGFQAKCYTVPENPAERTKLLLNIKVQTTDMKAVIEKTLDYRSKCIHAAATNLRK 303

  Fly   318 WFVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQT 382
            |.:.:.|:|:|:||||:|::||||||||||||||..||..::.:|..||..|||:||.|||.|:|
Worm   304 WGIMLLKLKSIFHTLNMFSVDVTQKCLIAECWVPEADIGQVKNSLHMGTIHSGSTVPAILNEMET 368

  Fly   383 FENPPTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLW 447
            .:.||||.:.||||:.||.::||||:|:|||:||||:|||:|||||||||||.|||.||.:....
Worm   369 DKYPPTYFKLNKFTQGFQNIVDAYGIANYREVNPAPWTIISFPFLFAVMFGDAGHGIIMLIAASA 433

  Fly   448 MIRKEKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLSYNKST 512
            .:..||.|.:.|..:||:|.||||||::.|||:|::|||.||||.:|||:|||||.|...||: |
Worm   434 FVIFEKKLISMKIKDEIFNTFFGGRYVVLLMGMFAIYTGFIYNDFYSKSVNIFGSSWVNPYNQ-T 497

  Fly   513 VMENKFLQ---------------LSPKGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIF 562
            ::.|...|               ::...||  .|||||:||:|.:| .|::.|.|..|||.||:.
Worm   498 LLANMDAQGADSNTDLSLTFPPEIAFNHDY--GPYPFGVDPVWNLA-INRLNFLNPMKMKTSILL 559

  Fly   563 GVIHMIFGVVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPY--- 624
            |:..|.||:::|..||...|:.:.:::.||||.:||..:|.|:.|.:.:|||.|..   ||.
Worm   560 GISQMAFGIMLSLMNHIGNRSVVDIVFVFIPQCLFLGCIFVYLCLQVLMKWIFFYV---KPAYIF 621

  Fly   625 -----SEACAPSILITFIDMVLF-------------------------NTPKPPPENCETYM--- 656
                 ...||||:||..|:|.:.                         |......:.|  |:
Worm   622 GRLYPGSNCAPSLLIGLINMFMVKSRDASFAHDVGTAAGKEWVIVNGQNVTYTINDQC--YLQQW 684

  Fly   657 FMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQANVQPIAGATSDAEAGGVSNSGSH---GG 718
            :..|..::::.:|:||..:|||||.||..|.....:                     |.|   |.
Worm   685 YPNQSLVELILLLIAVVSVPVMLLVKPFYIRWRHSR---------------------GLHIDLGH 728

  Fly   719 GGGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEG 783
            |.....|....:|.:||:|||||:|||.||||||||||||||||||||::|||||||.:.|...|
Worm   729 GPDEHGEFNFGDIMVHQAIHTIEFVLGCVSHTASYLRLWALSLAHAQLSDVLWTMVLRMSLTMGG 793

  Fly   784 PVGGIVLTCVFAF-WAILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAII 846
            ..|...:|.:|.| ::||:|.||:||||||||||.:||||||||||||.|.|..|:||.|..||
Worm   794 WGGSAAITILFYFIFSILSVCILILMEGLSAFLHAIRLHWVEFQSKFYGGTGIQFEPFCFTKII 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	385/877 (44%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	385/876 (44%)
vha-6	NP_496436.1	NtpI	28..858	CDD:224188	388/882 (44%)
vha-6	NP_496436.1	V_ATPase_I	28..853	CDD:279793	385/876 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830