DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-1 and Atp6v0a4

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_536715.3	Gene:	Atp6v0a4 / 140494	MGIID:	2153480	Length:	833	Species:	Mus musculus

Alignment Length:	883	Identity:	464/883 - (52%)
Similarity:	611/883 - (69%)	Gaps:	78/883 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |.|:||||||.|.|:|||.||||.||:||||||||||:|||.:||:||||||||||||:.:||.|
Mouse     1 MASVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLERIL 65

  Fly    66 RYLEKEIKKD---GIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTE 127
            |:||.|::.:   .:|..|.    |.|.|||||.||.|.||||.||:|.||:.:|||::||||||
Mouse    66 RFLEDEMQNEILIQVPEKDA----ETPLPREMITLETTLEKLEGELQEANQSHQALKKSFLELTE 126

  Fly   128 LKHILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNED----EQAQLLGEEGVRASQPG 188
            ||::|:|||.||:...                       |..||    :.:.||....:.|...|
Mouse   127 LKYLLKKTQDFFETET-----------------------NLGEDFFVEDTSGLLELRTIPAFMTG 168

  Fly   189 QNLKLGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQ 253
               ||||.||||.|||:.:|||:|||.|||||:|:.:.::|.||||...:::.|::||||:||:|
Mouse   169 ---KLGFTAGVINRERMASFERLLWRVCRGNVYLKFSEMDTLLEDPVTKEEIKKNIFIIFYQGEQ 230

  Fly   254 LKTRVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNW 318
            |:.::||||:|||||:|||||..|:||||...|..|:|||.||:.||:.||.|:|..||.|..:|
Mouse   231 LRLKIKKICDGFRATIYPCPEHAAERREMLTSVNVRLEDLITVITQTESHRQRLLQEAAANWHSW 295

  Fly   319 FVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTF 383
            .:||:|:||:||.||:.|:||||:|:|||.|.|:.|...|:.||.:|.|.||||:.||:..::|.
Mouse   296 VIKVQKMKAVYHVLNMCNIDVTQQCIIAEIWFPVADTRHIKKALEQGMELSGSSMIPIMTEVETK 360

  Fly   384 ENPPTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWM 448
            .:|||:|||||||..||.::|||||.||||:||||||||||||||||||||.|||.:|.:..|||
Mouse   361 TDPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGMVMLMAALWM 425

  Fly   449 IRKEKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL------- 506
            :..|:.|.|||:.||:|||||.|||:|.|||:||:||||||||.||||.|||||.|.:
Mouse   426 VLNERHLLAQKSTNEMWNIFFNGRYLILLMGIFSIYTGLIYNDCFSKSFNIFGSSWSVQPMFRNG 490

  Fly   507 SYNKSTVMENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIF 569
            ::|...|..:.:|||.|  .|.|.|.|||||:||||.:| :||:.|.|:||||:|:|.|:.||||
Mouse   491 TWNTHIVENSPYLQLDPAIPGVYSGNPYPFGIDPIWNLA-SNKLTFLNSYKMKMSVILGIAHMIF 554

  Fly   570 GVVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILI 634
            ||::|..||.|||..::::.:|||:::|:|.||.|:|.::..||.::.|     ::...||||||
Mouse   555 GVILSLFNHIYFRRTLNIILQFIPEMIFMLSLFGYLVFMIIFKWCRYDA-----HTSRKAPSILI 614

  Fly   635 TFIDMVLF------NTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQA 693
            .||.|.||      |.|          ::..|..:|..||::|:..:|.|||.||.::....:::
Mouse   615 HFIGMFLFDYDDSSNAP----------LYGHQQEVQTFFVIIALVSVPWMLLIKPFVLRAKHQKS 669

  Fly   694 NVQPIAGATSDAEAGGVS------NSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVSHTAS 752
            .:|... ...||..|..|      .:|:||...|||||....:||:||:||||||.||.:|:|||
Mouse   670 QLQSFT-IHEDAVEGDHSGHSSKKTAGAHGMKDGHEEEFNFGDIFVHQAIHTIEYCLGCISNTAS 733

  Fly   753 YLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHT 817
            ||||||||||||:|:|||||||:||||:.:|..|.:.:..:||.:|:|||.||::|||||||||.
Mouse   734 YLRLWALSLAHAELSEVLWTMVMSIGLRLQGWAGLVGVFIIFAVFAVLTVAILLVMEGLSAFLHA 798

  Fly   818 LRLHWVEFQSKFYKGQGYAFQPFSFDAIIENGAAAAEE 855
            |||||||||:|||:|.|..|.||||..::|   ..|||
Mouse   799 LRLHWVEFQNKFYEGAGSKFSPFSFKHVLE---GTAEE 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	439/842 (52%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	439/841 (52%)
Atp6v0a4	NP_536715.3	NtpI	28..824	CDD:224188	440/842 (52%)
		V_ATPase_I	28..823	CDD:279793	439/841 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	681..700		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	951	1.000	Domainoid score	I34
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1007	1.000	Inparanoid score	I289
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		otm43622
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840