Protein Alignment Vha100-1 and TCIRG1

DIOPT Version :10

• Sequence 1: NP_651672.1
• Gene: Vha100-1 / 43442
• FlyBaseID: FBgn0028671
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_006010.2
• Gene: TCIRG1 / 10312
• HGNCID: 11647
• Length: 830
• Species: Homo sapiens
• Alignment Length: 873
• Identity: 379/873 - (43%)
• Similarity: 530/873 - (60%)
• Gaps: 75/873 - (8%)

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |||:|||||:||.||||.:.|||.|||.|||||||:|||||..|:||||:||.:||||:|:|:..
Human     1 MGSMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEELEKTF 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            .:|::|:::.|:.:........||.||:::.::...|:|..|||:|..|.:||:....:|.....
Human    66 TFLQEEVRRAGLVLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRAQLHQLQLHAA 130

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQM--ADNQNEDEQAQLLGEEGVRASQPGQNLKL 193
            :||:                        ...||:  |......|:..||...|    .|.|:|::
Human   131 VLRQ------------------------GHEPQLAAAHTDGASERTPLLQAPG----GPHQDLRV 167

  Fly   194 GFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRV 258
            .||||.:...:.||.||:|||||||.:......:|.|||.|..|:......|:|.:.|:|:..::
Human   168 NFVAGAVEPHKAPALERLLWRACRGFLIASFRELEQPLEHPVTGEPATWMTFLISYWGEQIGQKI 232

  Fly   259 KKICEGFRATLYPCPEAPADRREMAMGVMTRI----EDLNTVLGQTQDHRHRVLVAAAKNLKNWF 319
            :||.:.|...::|.    ..:.|..:|.:.::    ::|..|||:|:....:||....:.|....
Human   233 RKITDCFHCHVFPF----LQQEEARLGALQQLQQQSQELQEVLGETERFLSQVLGRVLQLLPPGQ 293

  Fly   320 VKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFE 384
            |:|.|:||:|..||..::..|.||||||.|..:.|:..:|.|||..:...|  |..:.:|:...:
Human   294 VQVHKMKAVYLALNQCSVSTTHKCLIAEAWCSVRDLPALQEALRDSSMEEG--VSAVAHRIPCRD 356

  Fly   385 NPPTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMI 449
            .|||..|||:||.:||.::|||||..|:|:||||||||||||||||||||:|||.:|.||.|.|:
Human   357 MPPTLIRTNRFTASFQGIVDAYGVGRYQEVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMV 421

  Fly   450 RKEKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLS------- 507
            ..|...|.:...||||..||.|||::.|||:||:|||.|||:.||::.:||.|.|.::
Human   422 LAENRPAVKAAQNEIWQTFFRGRYLLLLMGLFSIYTGFIYNECFSRATSIFPSGWSVAAMANQSG 486

  Fly   508 YNKSTVMENKFLQLSPK--GDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFG 570
            ::.:.:.::..|.|.|.  |.:.| |||||:||||.:| ||.:.|.|::|||:|:|.||:||.||
Human   487 WSDAFLAQHTMLTLDPNVTGVFLG-PYPFGIDPIWSLA-ANHLSFLNSFKMKMSVILGVVHMAFG 549

  Fly   571 VVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILIT 635
            ||:...||.:|..|..||.|.:|:|.|||.||.|:|.|:..||:...|..     .|.||||||.
Human   550 VVLGVFNHVHFGQRHRLLLETLPELTFLLGLFGYLVFLVIYKWLCVWAAR-----AASAPSILIH 609

  Fly   636 FIDMVLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPL-LIMQARKQANVQPI- 698
            ||:|.||:   ..|.|  ..::..|..:|...|::|:..:|::||..|| |:.:.|::...:|.
Human   610 FINMFLFS---HSPSN--RLLYPRQEVVQATLVVLALAMVPILLLGTPLHLLHRHRRRLRRRPAD 669

  Fly   699 ------AGATS--DAEAGGVSNSGSHGGGGGHEEEEEL--SEIFIHQSIHTIEYVLGSVSHTASY 753
                  ||...  ||...|.|:.....||...|||.||  ||:.:||:|||||:.||.||:||||
Human   670 RQEENKAGLLDLPDASVNGWSSDEEKAGGLDDEEEAELVPSEVLMHQAIHTIEFCLGCVSNTASY 734

  Fly   754 LRLWALSLAHAQLAEVLWTMVLSI--GLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLH 816
            |||||||||||||:||||.||:.|  ||.:|..|..:||..:||.:|::||.||::|||||||||
Human   735 LRLWALSLAHAQLSEVLWAMVMRIGLGLGREVGVAAVVLVPIFAAFAVMTVAILLVMEGLSAFLH 799

  Fly   817 TLRLHWVEFQSKFYKGQGYAFQPFSFDA 844
            .|||||||||:|||.|.||...||:|.|
Human   800 ALRLHWVEFQNKFYSGTGYKLSPFTFAA 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	V_ATPase_I	27..842	CDD:460232	358/843 (42%)
TCIRG1	NP_006010.2	V_ATPase_I	27..825	CDD:460232	358/843 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..158		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	681..701		6/19 (32%)