DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-1 and si:ch73-173p19.2

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_021326052.1	Gene:	si:ch73-173p19.2 / 100332691	ZFINID:	ZDB-GENE-141212-282	Length:	831	Species:	Danio rerio

Alignment Length:	860	Identity:	423/860 - (49%)
Similarity:	590/860 - (68%)	Gaps:	46/860 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |..|||||||.|.|||||:|:|:.|::|||.||||||:||||...||||:||.||::|::|||.|
Zfish     2 MSCLFRSEEMCLVQLFLQTESAHNCINELGHLGLVQFKDLNPCATAFQRRFVKEVKKCEQMERIL 66

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            ||||||:.|..|.:..|.|....|..|::::||:||||||.||||:|.|.:.|::|.:||.::..
Zfish    67 RYLEKEMVKSNIVITATKEKEMVPCARDVLELESTFEKLEQELREINHNHDTLRQNLIELMDIDS 131

  Fly   131 ILRKTQVFFDESVPTV-YKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLKLG 194
            :||.|:.||:|:...: :..:.:|.|........:...:|.             :|.....|.||
Zfish   132 LLRMTEDFFEEAESLLTFSEASSYDSVSMTISSFITSRRNS-------------SSSTSGPLHLG 183

  Fly   195 FVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRVK 259
            |:||||.:||.||||::|||...||..||.|.|:|..|.......|.|..||||.|||.::.:::
Zfish   184 FIAGVIKQERFPAFEKVLWRLFHGNFVLRHAEIQTTEELEAVRGAVKKDAFIIFVQGDHVREKIR 248

  Fly   260 KICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVRK 324
            |:||||||:||.||:...:|:||:..:|||:|||..||.:|:::|..||..||::::.|..||:|
Zfish   249 KVCEGFRASLYSCPKTLYERKEMSNSIMTRMEDLRLVLRRTEEYRAGVLSRAAEHVQEWGSKVKK 313

  Fly   325 IKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPTY 389
            :||||:||||.|:|:|||.::||.|.|:.|:..:|.||.:|:|:|||||.|:|||:||.:.|||:
Zfish   314 MKAIYYTLNLCNIDITQKLIVAEIWCPVSDLTVVQNALIKGSEQSGSSVTPVLNRIQTKQTPPTF 378

  Fly   390 NRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEKG 454
            ||||.||:.|||:||||||.:|:|:||||||||||||||||||||.|||.:||||.:|:|.:...
Zfish   379 NRTNSFTEGFQAIIDAYGVGTYQEINPAPYTIITFPFLFAVMFGDCGHGLLMALFSVWLITQADY 443

  Fly   455 LAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHW--------HLSYNKS 511
            :  :|..||:.::..|||:||.|||:||:||||||||.||||.|||||.|        |.|:...
Zfish   444 I--RKWKNELTDVLVGGRFIILLMGLFSIYTGLIYNDCFSKSFNIFGSSWCVRPMFHPHGSWQNE 506

  Fly   512 TVMENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMS 574
            |:.::..|||:|  .|.:.|.||.||:||||.:| :||:.|.|::|||:|:|.||.||:|||.:|
Zfish   507 TLHDHHHLQLNPFVPGVFSGHPYVFGIDPIWNIA-SNKLSFLNSFKMKMSVILGVAHMLFGVTLS 570

  Fly   575 WHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDM 639
            ..|..:||....:|.:|:|||||:|.||.|::.|:..||       ....|...|||||:.||.|
Zfish   571 LVNFLHFRKFQDILLQFVPQLVFMLCLFGYLIFLILYKW-------SVSLSSEMAPSILLLFISM 628

  Fly   640 VLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQANVQPIAGATSD 704
            :||:.   .|::  ..::.||..:|:..|:.||..:||:||.||.||.::|.:...|....:..|
Zfish   629 MLFDY---QPDH--KLLYGGQKAVQICLVVTAVLMVPVLLLVKPFLIYRSRMKTRHQVFGNSLDD 688

  Fly   705 AEAGGVSNSGSHGGGGGHEEEEELS--EIFIHQSIHTIEYVLGSVSHTASYLRLWALSLAHAQLA 767
            .:.....:|.:.     |:::|.:|  ::|::|:||||||.||.:|:|||||||||||||||:|:
Zfish   689 QQCTDKRSSFAR-----HQKDETVSMGDVFVYQAIHTIEYCLGCISNTASYLRLWALSLAHAELS 748

  Fly   768 EVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYKG 832
            ||||.|||..|||....:|.::|..:||.:|:|||.:|::|||||||||.|||||||||:|||:|
Zfish   749 EVLWRMVLQAGLKLSFGLGSLMLALLFAAFAVLTVTVLLVMEGLSAFLHALRLHWVEFQNKFYEG 813

  Fly   833 QGYAFQPFSFDAIIE 847
            .||.|.|.|||::::
Zfish   814 SGYKFTPLSFDSLLK 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	403/827 (49%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	403/826 (49%)
si:ch73-173p19.2	XP_021326052.1	V_ATPase_I	28..823	CDD:307581	403/827 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930