Protein Alignment Vha100-1 and atp6v0a4

DIOPT Version :10

• Sequence 1: NP_651672.1
• Gene: Vha100-1 / 43442
• FlyBaseID: FBgn0028671
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001107162.1
• Gene: atp6v0a4 / 100135019
• XenbaseID: XB-GENE-493197
• Length: 846
• Species: Xenopus tropicalis
• Alignment Length: 874
• Identity: 470/874 - (53%)
• Similarity: 604/874 - (69%)
• Gaps: 60/874 - (6%)

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |.||||||||:|.||.||.||.|.|::||||||||||||||..||:|||:||||||||:.|||.|
 Frog     1 MASLFRSEEMSLTQLILQVEAGYCCIAELGELGLVQFRDLNASVNSFQRRFVNEVRRCENMERIL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            |:||.|:..|.|.:....:.|:.|.||||||||...||||.||:|||:|.:|||:||||||||||
 Frog    66 RFLESEMVNDKIKIRTPEKLPQTPLPREMIDLETVLEKLEGELQEVNRNQQALKQNFLELTELKH 130

  Fly   131 ILRKTQVFF--DESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLKL 193
            :|:|||.||  :.::|..:.|....|..:.|..|.                    |:..|   ||
 Frog   131 LLKKTQDFFEAEANLPDDFFSEDTSSLLELRTIPS--------------------AAAAG---KL 172

  Fly   194 GFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRV 258
            ||.||||.|||:..|||:|||.||||::|:...::|.||||...::|.|:|||||:||||||.::
 Frog   173 GFTAGVINRERMATFERLLWRVCRGNIYLKYTELDTALEDPVTKEEVKKNVFIIFYQGDQLKLKI 237

  Fly   259 KKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVR 323
            ||||:||:||:|||||:..:|:||...|.|||||||||:.||:.||.|||:.||::|.:|.:||:
 Frog   238 KKICDGFKATVYPCPESATERKEMVADVNTRIEDLNTVITQTESHRQRVLLEAAQSLCSWGIKVK 302

  Fly   324 KIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPT 388
            |:||:||.|||.|:||||:|:|||.|.|:.|.|.|:.||.||.|||||::.|||..:.:..:|||
 Frog   303 KMKAVYHVLNLCNIDVTQQCVIAEIWCPIADKEQIKQALHRGMERSGSTIAPILTNISSKLDPPT 367

  Fly   389 YNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEK 453
            :|||||||..||.:::||||.|||||||.|||||||||||||||||.|||::|..|.|||:..||
 Frog   368 FNRTNKFTSGFQNIVNAYGVGSYREMNPTPYTIITFPFLFAVMFGDCGHGSVMLGFALWMVLNEK 432

  Fly   454 GLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL-------SYNKS 511
            .|.|.||||||||.||||||:|.||.:||:|||.||||.||||.:||||.|.:       ::|.:
 Frog   433 QLLASKTDNEIWNTFFGGRYLILLMSIFSIYTGFIYNDCFSKSFDIFGSSWRVRPMFINKTWNDN 497

  Fly   512 TVMENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMS 574
            .|.:...|||.|  .|.|.|.|||||:||||.:| .||:.|.|:||||:|::.|:..|:|||::.
 Frog   498 LVHQGLQLQLDPAVPGVYSGNPYPFGIDPIWNIA-QNKLTFLNSYKMKMSVVMGITQMVFGVMLG 561

  Fly   575 WHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDM 639
            ..||..|:..|:::.:|:|:::|::.||.|:|.::..||.|:..     :|...||||||.||:|
 Frog   562 LLNHINFKRPINIILQFVPEMIFIICLFGYLVFMIIFKWCKYDV-----HSSQGAPSILIHFINM 621

  Fly   640 VLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIM--QARKQANVQPIAGAT 702
            .|||  ...|.|...|..  |..:|...|:.|:..:|.|||.||.::.  ..:.|..:|..:|..
 Frog   622 FLFN--YSDPTNAPLYEH--QKEVQTFLVIFALIAVPWMLLIKPFVLRANHLKAQRMLQSSSGPE 682

  Fly   703 SDAEAGGVSNS-------------GSHGGG-GGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASY 753
            ..||...|.|:             |.|||| |.|.||.:..:||:||:||||||.||.:|:||||
 Frog   683 DHAELTDVENAHANHKSKKEEHGGGDHGGGHGEHGEEFDFGDIFVHQAIHTIEYCLGCISNTASY 747

  Fly   754 LRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTL 818
            |||||||||||||:|||||||:..||...|..|.|.:..:||.:|:|||.||::|||||||||.|
 Frog   748 LRLWALSLAHAQLSEVLWTMVMHQGLSIGGYGGLIGVFIIFAAFAVLTVAILLVMEGLSAFLHAL 812

  Fly   819 RLHWVEFQSKFYKGQGYAFQPFSFDAIIE 847
            ||||||||:|||.|.|:.|.||||.:|:|
 Frog   813 RLHWVEFQNKFYAGTGHLFSPFSFQSILE 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	V_ATPase_I	27..842	CDD:460232	448/841 (53%)
atp6v0a4	NP_001107162.1	V_ATPase_I	27..836	CDD:460232	448/841 (53%)