DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-1 and atp6v0a4

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001107162.1	Gene:	atp6v0a4 / 100135019	XenbaseID:	XB-GENE-493197	Length:	846	Species:	Xenopus tropicalis

Alignment Length:	874	Identity:	470/874 - (53%)
Similarity:	604/874 - (69%)	Gaps:	60/874 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            |.||||||||:|.||.||.||.|.|::||||||||||||||..||:|||:||||||||:.|||.|
Frog     1 MASLFRSEEMSLTQLILQVEAGYCCIAELGELGLVQFRDLNASVNSFQRRFVNEVRRCENMERIL 65

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            |:||.|:..|.|.:....:.|:.|.||||||||...||||.||:|||:|.:|||:||||||||||
Frog    66 RFLESEMVNDKIKIRTPEKLPQTPLPREMIDLETVLEKLEGELQEVNRNQQALKQNFLELTELKH 130

  Fly   131 ILRKTQVFF--DESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLKL 193
            :|:|||.||  :.::|..:.|....|..:.|..|.                    |:..|   ||
Frog   131 LLKKTQDFFEAEANLPDDFFSEDTSSLLELRTIPS--------------------AAAAG---KL 172

  Fly   194 GFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRV 258
            ||.||||.|||:..|||:|||.||||::|:...::|.||||...::|.|:|||||:||||||.::
Frog   173 GFTAGVINRERMATFERLLWRVCRGNIYLKYTELDTALEDPVTKEEVKKNVFIIFYQGDQLKLKI 237

  Fly   259 KKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVR 323
            ||||:||:||:|||||:..:|:||...|.|||||||||:.||:.||.|||:.||::|.:|.:||:
Frog   238 KKICDGFKATVYPCPESATERKEMVADVNTRIEDLNTVITQTESHRQRVLLEAAQSLCSWGIKVK 302

  Fly   324 KIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPT 388
            |:||:||.|||.|:||||:|:|||.|.|:.|.|.|:.||.||.|||||::.|||..:.:..:|||
Frog   303 KMKAVYHVLNLCNIDVTQQCVIAEIWCPIADKEQIKQALHRGMERSGSTIAPILTNISSKLDPPT 367

  Fly   389 YNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEK 453
            :|||||||..||.:::||||.|||||||.|||||||||||||||||.|||::|..|.|||:..||
Frog   368 FNRTNKFTSGFQNIVNAYGVGSYREMNPTPYTIITFPFLFAVMFGDCGHGSVMLGFALWMVLNEK 432

  Fly   454 GLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL-------SYNKS 511
            .|.|.||||||||.||||||:|.||.:||:|||.||||.||||.:||||.|.:       ::|.:
Frog   433 QLLASKTDNEIWNTFFGGRYLILLMSIFSIYTGFIYNDCFSKSFDIFGSSWRVRPMFINKTWNDN 497

  Fly   512 TVMENKFLQLSP--KGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMS 574
            .|.:...|||.|  .|.|.|.|||||:||||.:| .||:.|.|:||||:|::.|:..|:|||::.
Frog   498 LVHQGLQLQLDPAVPGVYSGNPYPFGIDPIWNIA-QNKLTFLNSYKMKMSVVMGITQMVFGVMLG 561

  Fly   575 WHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDM 639
            ..||..|:..|:::.:|:|:::|::.||.|:|.::..||.|:..     :|...||||||.||:|
Frog   562 LLNHINFKRPINIILQFVPEMIFIICLFGYLVFMIIFKWCKYDV-----HSSQGAPSILIHFINM 621

  Fly   640 VLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIM--QARKQANVQPIAGAT 702
            .|||  ...|.|...|..  |..:|...|:.|:..:|.|||.||.::.  ..:.|..:|..:|..
Frog   622 FLFN--YSDPTNAPLYEH--QKEVQTFLVIFALIAVPWMLLIKPFVLRANHLKAQRMLQSSSGPE 682

  Fly   703 SDAEAGGVSNS-------------GSHGGG-GGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASY 753
            ..||...|.|:             |.|||| |.|.||.:..:||:||:||||||.||.:|:||||
Frog   683 DHAELTDVENAHANHKSKKEEHGGGDHGGGHGEHGEEFDFGDIFVHQAIHTIEYCLGCISNTASY 747

  Fly   754 LRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTL 818
            |||||||||||||:|||||||:..||...|..|.|.:..:||.:|:|||.||::|||||||||.|
Frog   748 LRLWALSLAHAQLSEVLWTMVMHQGLSIGGYGGLIGVFIIFAAFAVLTVAILLVMEGLSAFLHAL 812

  Fly   819 RLHWVEFQSKFYKGQGYAFQPFSFDAIIE 847
            ||||||||:|||.|.|:.|.||||.:|:|
Frog   813 RLHWVEFQNKFYAGTGHLFSPFSFQSILE 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	448/841 (53%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	448/840 (53%)
atp6v0a4	NP_001107162.1	NtpI	26..838	CDD:224188	450/844 (53%)
atp6v0a4	NP_001107162.1	V_ATPase_I	28..836	CDD:279793	448/840 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	936	1.000	Domainoid score	I43
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	984	1.000	Inparanoid score	I310
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		otm48785
Panther	1	1.100	-	-	O	PTHR11629
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160