DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-1 and atp6v0a1

DIOPT Version :9

Sequence 1:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_031749790.1	Gene:	atp6v0a1 / 100036694	XenbaseID:	XB-GENE-959346	Length:	871	Species:	Xenopus tropicalis

Alignment Length:	874	Identity:	516/874 - (59%)
Similarity:	629/874 - (71%)	Gaps:	61/874 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65
            ||.|||||||.|.||||||||||.|||||||||.|||||||||||.||||||||||||:||:|||
Frog    27 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKL 91

  Fly    66 RYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKH 130
            |::|||:||..|.:|||||:||.|.||:||||||.|||:|.||:|:|.|.||||||||||||||.
Frog    92 RFVEKEVKKANISILDTGENPEVPFPRDMIDLEANFEKIEIELKEINTNQEALKRNFLELTELKF 156

  Fly   131 ILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLKLGF 195
            ||||||.||||              ::...:.||||....:|.:.||....:....|   |:|||
Frog   157 ILRKTQQFFDE--------------AQLHHHQQMADPDLLEESSSLLEPSEMGRGAP---LRLGF 204

  Fly   196 VAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRVKK 260
            |||||.|||:|.|||||||.||||||||||.||.|||||..||.||||||||||||||||.||||
Frog   205 VAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDSVHKSVFIIFFQGDQLKNRVKK 269

  Fly   261 ICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVRKI 325
            |||||||:||||||.|.:|:|||.||.||||||..||.||:|||.|||.||||:|:.||:||||:
Frog   270 ICEGFRASLYPCPETPQERKEMATGVNTRIEDLQMVLNQTEDHRQRVLQAAAKSLRVWFIKVRKM 334

  Fly   326 KAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPTYN 390
            |||||||||.|:||||||||||.|.|:.|:::||.|||||||.|||:||.|||||||.:.|||||
Frog   335 KAIYHTLNLCNIDVTQKCLIAEVWCPVADLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYN 399

  Fly   391 RTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEKGL 455
            :|||||..||.|:||||:.||||:||||||||||||||||||||.|||.:|.||.:||:.:|..:
Frog   400 KTNKFTYGFQNLVDAYGIGSYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVVRESRI 464

  Fly   456 AAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHL------SYNKSTVM 514
            .:||.|||::.:.|.|||||.|||:||:||||||||.|||:||:|||.|.:      ::::..:.
Frog   465 LSQKIDNELFTMMFSGRYIILLMGLFSIYTGLIYNDCFSKALNLFGSSWSVRPMFTDTWSEDLLK 529

  Fly   515 ENKFLQLSPK--GDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWHN 577
            ....|||:|.  |.:.| |||||:||||.:| .||:.|.|::|||:|::.|:|||.|||.:|..|
Frog   530 HTSVLQLNPNVTGVFNG-PYPFGIDPIWSLA-TNKLTFLNSFKMKMSVVLGIIHMTFGVALSLLN 592

  Fly   578 HTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDMVLF 642
            |.||:..:::...|||:::|:..||.|:|:|:..||..:.|:     :...|||:||.||:|.||
Frog   593 HIYFKKPLNIYLGFIPEMIFMTTLFGYLVILIIYKWCAYDAS-----TSMVAPSLLIHFINMFLF 652

  Fly   643 ---NTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQ---ARKQANVQPIAG- 700
               :|..|       .::.||..:|...|:.|:.|:|.||:.|||::.:   .||........|
Frog   653 SYQDTSLP-------MLYKGQMGLQCFLVVCAIICVPWMLVVKPLILRRQYLRRKHLGTHNFGGI 710

  Fly   701 ------ATSDAEAGGVSNSGSHGGGGGHEEEEELSEIF------IHQSIHTIEYVLGSVSHTASY 753
                  ...|||.........|...|   ||..:.|:|      :||:||||||.||.:|:||||
Frog   711 RVGNGPTEEDAEIIQHDQLSMHSEEG---EEPAMEEVFDFGDTVVHQAIHTIEYCLGCISNTASY 772

  Fly   754 LRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTL 818
            |||||||||||||:|||||||:.:||......|||.|..||:.:|.||:.||::|||||||||.|
Frog   773 LRLWALSLAHAQLSEVLWTMVMHVGLSIRSLGGGIALVFVFSAFATLTIAILLIMEGLSAFLHAL 837

  Fly   819 RLHWVEFQSKFYKGQGYAFQPFSFDAIIE 847
            ||||||||:|||.|.|:.|.||||:.|.|
Frog   838 RLHWVEFQNKFYMGTGFKFLPFSFENIRE 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	490/841 (58%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	489/840 (58%)
atp6v0a1	XP_031749790.1	V_ATPase_I	53..861	CDD:396194	490/841 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	936	1.000	Domainoid score	I43
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3795
Inparanoid	1	1.050	984	1.000	Inparanoid score	I310
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		otm48785
Panther	1	1.100	-	-	LDO	PTHR11629
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2333
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110