DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgt6 and HAUS6

DIOPT Version :9

Sequence 1:	NP_651671.1	Gene:	dgt6 / 43441	FlyBaseID:	FBgn0039638	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_060115.3	Gene:	HAUS6 / 54801	HGNCID:	25948	Length:	955	Species:	Homo sapiens

Alignment Length:	823	Identity:	163/823 - (19%)
Similarity:	298/823 - (36%)	Gaps:	249/823 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QSEKLHRKLQGLALVHPLPDELR--KLIAW-----DMFLKPNQVAFVHVMHYLFRLLDPAEFKR- 72
            :.|.|...||.|.. .|.|..:.  |:::.     :||.|.|:.||..:.::||::||.:..|.
Human    10 EKEHLWMYLQALGF-EPGPATIACGKIVSHTHLGVNMFDKLNRDAFHIISYFLFQVLDQSLTKEV 73

  Fly    73 -RFFWPITDKKSEANFRSSTVEYLKHLNEKHQLHWANIKSYLVVMPGGMRFINFLLEFVGFVIQE 136
             :|.||..|:||:..||....|::|.::.:....:..:...|.:.|||.:||:.:..|..||..:
Human    74 FKFCWPPFDQKSDTEFRKHCCEWIKRISGECGSSFPQVVGSLFLSPGGPKFIHLMYHFARFVAMK 138

  Fly   137 LIKQREKSLGLE-AGTPNVS------------------AKVMARQNAVMKEYAS----------- 171
            .||...|:.... ..|.|:.                  .:::.||:.|.::|..
Human   139 YIKSNSKNSSHHFVETFNIKPQDLHKCIARCHFARSRFLQILQRQDCVTQKYQENAQLSVKQVRN 203

  Fly   172 --SYVVNLE---------ENTALLRDKTQKIRRLMADLSADMGVPEE-------------QLADD 212
              |..:.||         ::.:.:.:|.||:|.|.|.::..:...|:             |.|.|
Human   204 LRSECIGLENQIKKMEPYDDHSNMEEKIQKVRSLWASVNETLMFLEKEREVVSSVLSLVNQYALD 268

  Fly   213 GFLDEFEATAALGVERVITQPTERK-FDL------EASLCGLKEAIDL----FQVKQAENNQSKE 266
            |      ...|:.:.|::....|:: |.|      ||....|...|.|    .:|.:.|..|:.:
Human   269 G------TNVAINIPRLLLDKIEKQMFQLHIGNVYEAGKLNLLTVIQLLNEVLKVMKYERCQADQ 327

  Fly   267 A--------VEKA----------LRGMRVLFDCDAVT--------EGDFY----DPLGASKMDAL 301
            |        :||.          |:.||.....|..|        :|:::    :.||.|.. :|
Human   328 ARLTVDLHYLEKETKFQKERLSDLKHMRYRIKDDLTTIRHSVVEKQGEWHKKWKEFLGLSPF-SL 391

  Fly   302 LNG---------------FNRISGTI----------AEQLDANDHYNESNA-------------F 328
            :.|               |:..|..:          |...||:..:|:.|.             .
Human   392 IKGWTPSVDLLPPMSPLSFDPASEEVYAKSILCQYPASLPDAHKQHNQENGCRGDSDTLGALHDL 456

  Fly   329 VTTDLQALRVELSQSEVQLNNLLK---KLNEPSKKDKGSANASGSARVQTLQPATPRFESVISSK 390
            ..:....|...:|.|:.....:|:   |:..|.:|:            :.:....|.||  :.:.
Human   457 ANSPASFLSQSVSSSDRNSVTVLEKDTKMGTPKEKN------------EAISKKIPEFE--VENS 507

  Fly   391 FVSTPPIRIDMGGGGGRNAPVRLALQDDFNGKQ---FDALSNSLLAPAPPRSAR---KLKALDQS 449
            .:|......:....|| :.|.:.:  |.|..:|   .:.::.::|:.:|..|..   ||:.|..|
Human   508 PLSDVAKNTESSAFGG-SLPAKKS--DPFQKEQDHLVEEVARAVLSDSPQLSEGKEIKLEELIDS 569

  Fly   450 TGIDLNGTLNRSKINDPMQMLRTIHKNTSKVKAAPQANLSSLGSKW-KQMQASFGFDEAPVPGAA 513
            .|  .|..|.|:      |:.||           |:..::.:.|.| |.::......:.|:...|
Human   570 LG--SNPFLTRN------QIPRT-----------PENLITEIRSSWRKAIEMEENRTKEPIQMDA 615

  Fly   514 ---VISPQTSP----------------TDPSD-------PFTPLSGSEC--------TRIERIPR 544
               .:.|::.|                |..||       ....:|..||        :.|:..|
Human   616 EHREVLPESLPVLHNQREFSMADFLLETTVSDFGQSHLTEEKVISDCECVPQKHVLTSHIDEPP- 679

  Fly   545 TSENNTSLIAKSA---------AVIKVLEVSRNVLNLSTSPSGRLDALVPHTE------SHQQDV 594
             ::|.:.|:.|..         |..|:.|.|| :...|.:...|:|.:....|      .|.:..
Human   680 -TQNQSDLLNKKVICKQDLECLAFTKLSETSR-METFSPAVGNRIDVMGGSEEEFMKILDHLEVS 742

  Fly   595 APRLQLNDRTINDSLQLDPDFNIENDK-NAFNVSHKFDFDQIG 636
            ..:...|...:.:|.|:....:.::.| |.|.:.|:...:::|
Human   743 CNKPSTNKTMLWNSFQISSGISSKSFKDNDFGILHETLPEEVG 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgt6	NP_651671.1	HAUS6_N	21..257	CDD:317106	69/309 (22%)
HAUS6	NP_060115.3	HAUS6_N	15..239	CDD:291333	53/224 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..495		4/32 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..814
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	848..877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28NJA
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto91278
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16151
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5331
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.920