DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgt6 and haus6

DIOPT Version :9

Sequence 1:	NP_651671.1	Gene:	dgt6 / 43441	FlyBaseID:	FBgn0039638	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001135620.2	Gene:	haus6 / 100216179	XenbaseID:	XB-GENE-987220	Length:	980	Species:	Xenopus tropicalis

Alignment Length:	826	Identity:	172/826 - (20%)
Similarity:	279/826 - (33%)	Gaps:	274/826 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QSEKLHRKLQGL-------------ALVHPLPDELRKLIAWDMFLKPNQVAFVHVMHYLFRLLDP 67
            |.|.:...||||             .|.|....|       :||.|||:.||..|.|:||..||.
Frog    12 QREHMWLALQGLGFESGVAATIAGKTLAHVTFGE-------NMFDKPNKDAFYVVFHFLFGKLDN 69

  Fly    68 AEFKR--RFFWPITDKKSEANFRSSTVEYLKHLNEKHQLHWANIKSYLVVMPGGMRFINFLLEFV 130
            ...|.  |:.||..:||.:|.||.:..|:||.::::....:..:.:.:.:.|||.:|::.|..|.
Frog    70 MRCKEVFRYCWPPIEKKRDAEFRKACYEWLKKISDEVGAGFPQVVASIFLSPGGPKFVHLLYHFA 134

  Fly   131 GFVIQELIKQ-------------------REKSLGLEAGTPNVSAKVMARQNAVMKEY------- 169
            .:|:.:.||:                   .:|:|............|:.|:|.|:|||
Frog   135 RYVMLQHIKRDANGASVFISEALQCKIQDPQKALARNKVARQKYLMVLQRENLVIKEYQRKAQLL 199

  Fly   170 -------ASSYV------VNLEENTALLRDKTQKIRRLMADLSADMGV-----PEEQLAD---DG 213
                   .|.:|      :.:|:....:.||.:.|.::....:|.|.:     .|..:.|   .|
Frog   200 IKQIRDMRSEHVALQNQQIMIEKVNGNISDKDENILKIRCMWNAVMQMLKMIEKEVDVVDAVVRG 264

  Fly   214 FLDEFE---ATAALGVERVITQPTE---RKFDLEASLCGLKEA--IDLFQVKQAENNQSKEAVEK 270
            .:|::.   ....|.:..::....|   .:..:|    .:.||  ::|..|.|..|    ||: |
Frog   265 NIDQYSLDGTNTTLNIPNLLISRIESEMHRLQME----NVYEAGKVNLLTVVQLLN----EAL-K 320

  Fly   271 ALRGMRVLFDCDAVTEGDFYDPLGASKMD-ALLNGFNRISGTIAEQLDANDHYNESNAFVTTDLQ 334
            .:.|.|.|.||..:            .:| ..|||..:....:..:|     .|........||.
Frog   321 LVNGERCLHDCKEI------------HLDLQYLNGKAKFESEVLTRL-----RNMRQKIKREDLM 368

  Fly   335 ALRVELSQSEVQLNNLLKKL--NEPSKKDKGSANASGSARVQTLQPA------------TPRFES 385
            ::...:|..|.:.....:|:  ..|....||            |.||            .|..|.
Frog   369 SIEKSISDKEREWERKWEKILGKSPFSLLKG------------LNPALELNPPMAPFSFDPASEE 421

  Fly   386 VI-SSKFVSTP--------------PIRIDMGG-------------GGGRNA------PVRLAL- 415
            |: ||.|...|              .:..|.||             ..|||:      |:|..:
Frog   422 VLKSSVFCHYPASLPDYSHKEKALKDLNQDHGGELLQRLIGATVLTPSGRNSSRGIATPIRRRMS 486

  Fly   416 ----------QDDFNGKQ---------------FDALSNSLL--APAPPRSARKLKALDQ----- 448
                      .:|..|.|               :...:||.|  .|.|.:...|..|..|
Frog   487 LNEKDFKTPNMNDRTGFQRTPSSSVQKRRSDVSWKTAANSPLPHTPTPCKQDPKNMARQQLAQQV 551

  Fly   449 ----------STG------IDLNGTLNRSKINDPMQMLRTIHKNTSKVKAAPQANLSSLGSKW-K 496
                      |:|      .||.|.|:    :||.       .:..::...|:..:|.:.|.| |
Frog   552 ADYIVSETPRSSGGRGMELDDLLGILS----SDPF-------LSRKEIPRTPENLISDIRSSWRK 605

  Fly   497 QMQASFGFDEA-PVPGAAVISPQTSPTDPSDPFTPLSGSECTRIE-------------------- 540
            .:|:....|.| |||...:           |....|..:.|::|:
Frog   606 AIQSEESSDVASPVPAPCM-----------DSTAELESAHCSQIDLSMACFLSTSHASDQNDCSG 659

  Fly   541 -RIPRTSENNTSLIAKSA-AVIKVLEVSRNVLNLSTSPSGRLDALVPHTESHQQDVAPRLQLNDR 603
             |||   .|.:...|.|. :.:...|:|.....:.:...|  |..:|..||...|..  :.|.|.
Frog   660 TRIP---PNTSGTCAPSLHSDVGHQEISHQKSEIDSLKPG--DLSLPIKESRHADTL--INLLDD 717

  Fly   604 TINDSLQLDPDFNIENDKNAF-----NVSHKFD---FDQIGGEDDL 641
            .|.::...|.......:||..     ::|...|   |..:.|:::|
Frog   718 KIEENENADTMIKPTENKNKIVFGNQSISKLIDKTMFISVSGQENL 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgt6	NP_651671.1	HAUS6_N	21..257	CDD:317106	68/305 (22%)
haus6	NP_001135620.2	HAUS6_N	20..242	CDD:373201	56/228 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9520
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto105057
Panther	1	1.100	-	-	LDO	PTHR16151
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5331
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.130