DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl2 and SLC44A4

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_079533.2	Gene:	SLC44A4 / 80736	HGNCID:	13941	Length:	710	Species:	Homo sapiens

Alignment Length:	815	Identity:	279/815 - (34%)
Similarity:	413/815 - (50%)	Gaps:	147/815 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCG 75
            ||:|::||.:|.|| .::||||||.|.:||:||:.|:..:...|...||..::|.|.:|....||
Human    13 YGKPVKYDPSFRGP-IKNRSCTDVICCVLFLLFILGYIVVGIVAWLYGDPRQVLYPRNSTGAYCG 76

  Fly    76 MDSGVLNKKNLFFFDLNQCI--DPLVPIT----GCDTPQVCVETCPRETFVWDTMKDK--QSFAE 132
            |... .:|..|.:|::..||  ..::.:.    .|.||||||.:||.:.  |...|::  |:..|
Human    77 MGEN-KDKPYLLYFNIFSCILSSNIISVAENGLQCPTPQVCVSSCPEDP--WTVGKNEFSQTVGE 138

  Fly   133 L---HSRLICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCLFEFSQGVCDYIPSFLL 194
            :   .:|..||     ..:.....:..::.|..|..:.:.|||.|.|| |.::    :..|.
Human   139 VFYTKNRNFCL-----PGVPWNMTVITSLQQELCPSFLLPSAPALGRC-FPWT----NVTPP--- 190

  Fly   195 NGGRSRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLNEAV 259
                      .|||
Human   191 ----------ALPG--------------------------------------------------- 194

  Fly   260 IKEKMMQTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYIAL 324
                 :..||.:.:.:..::     .:.:|:.:..||.||...||..:|||....||.||::|.|
Human   195 -----ITNDTTIQQGISGLI-----DSLNARDISVKIFEDFAQSWYWILVALGVALVLSLLFILL 249

  Fly   325 MRWLSAPILWFSIFGVLIGLLVGIYFSVKQYIHWENTPTVPVHGLNL----HSTVKNVLQN-QNT 384
            :|.::.|::...|.|||..|..|||:.      ||....:...|.::    .:|..:..|: |.|
Human   250 LRLVAGPLVLVLILGVLGVLAYGIYYC------WEEYRVLRDKGASISQLGFTTNLSAYQSVQET 308

  Fly   385 WLYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAI 449
            ||...|.:.|...::||::|.||:||||||||.||.||||..::||:|:|:.:::|.:..||:..
Human   309 WLAALIVLAVLEAILLLMLIFLRQRIRIAIALLKEASKAVGQMMSTMFYPLVTFVLLLICIAYWA 373

  Fly   450 GVGLYLGSIGDPSFRM-VRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQ 513
            ...|||.:.|.|.:.: ...::..|        ||...||    .||.|           |:...
Human   374 MTALYLATSGQPQYVLWASNISSPG--------CEKVPIN----TSCNP-----------TAHLV 415

  Fly   514 NRNPCLNTTCSFDSINNPIEIKWAIF----YNVFGFLWLSFFISAFSYMVLASTFARWYWTF-KK 573
            | :.|....|.|...::...|:.::|    |.|.|..|...::.|....|||..||.:||.| |.
Human   416 N-SSCPGLMCVFQGYSSKGLIQRSVFNLQIYGVLGLFWTLNWVLALGQCVLAGAFASFYWAFHKP 479

  Fly   574 RDVPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCF 638
            :|:|.|.|..||.:|..||.|::|||:|||.:|::.|::||||..||:...|.|.|.|:||.:|.
Human   480 QDIPTFPLISAFIRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGVQNPVARCIMCCFKCC 544

  Fly   639 FWLLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAG 703
            .|.||.|:||||||||||.||:|||||.||.::|.|:|||.:|||.||:|||.|.|..|||:..|
Human   545 LWCLEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNIVRVVVLDKVTDLLLFFGKLLVVGG 609

  Fly   704 AGASTYYFLDNN-PSIIR------LNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDC 761
            .|..:::|.... |.:.:      |||..:|....::.|::|.|.||.|:...|||||||||||.
Human   610 VGVLSFFFFSGRIPGLGKDFKSPHLNYYWLPIMTSILGAYVIASGFFSVFGMCVDTLFLCFLEDL 674

  Fly   762 ERNDGSPEKPFFMSKQLMKILGKKNNLPPRQRRGK 796
            |||:||.::|::|||.|:|||||||..||..::.|
Human   675 ERNNGSLDRPYYMSKSLLKILGKKNEAPPDNKKRK 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	152/366 (42%)
SLC44A4	NP_079533.2	Choline_transpo	313..674	CDD:282384	158/384 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1679
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11359
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1599
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53694
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm41863
orthoMCL	1	0.900	-	-		OOG6_100798
Panther	1	1.100	-	-	O	PTHR12385
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2467
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870