DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl2 and Slc44a4

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	XP_006524948.1	Gene:	Slc44a4 / 70129	MGIID:	1917379	Length:	716	Species:	Mus musculus

Alignment Length:	804	Identity:	271/804 - (33%)
Similarity:	397/804 - (49%)	Gaps:	142/804 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCGM 76
            |...:||.:|.|| .::|.|||:.|.:||::|:.|:..:...|...||..::|.|.:|....||:
Mouse    21 GNSAKYDPSFRGP-IKNRGCTDIICCVLFLIFILGYIIVGLVAWVYGDPRQVLYPRNSTGAYCGV 84

  Fly    77 DSGVLNKKNLFFFDLNQCIDPLVPIT------GCDTPQVCVETCPRETFVWDTMKDKQSFAELHS 135
            ... .:|..:.:||:..|...:..|:      .|.||||||.:||...:..:..:..::..|::.
Mouse    85 GDN-KDKPYVLYFDILSCAAAINIISIAENGLQCPTPQVCVSSCPLAPWAVEVFQFSKTVGEVYG 148

  Fly   136 --RLICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCLFEFSQGVCDYIPSFLLNGGR 198
              |..||.......|     :::::.:..|.|:.:.|.|.|.||.
Mouse   149 ERRNFCLPAVSPDMI-----VEESLQKGLCPRFLLPSTPALGRCF-------------------- 188

  Fly   199 SRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQT-PVDEEPIIQCKRRLNEAVIKE 262
                                               |..|...| |.|        .|:|...
Mouse   189 -----------------------------------PLPNINFTLPED--------LRINNTT--- 207

  Fly   263 KMMQTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYIALMRW 327
                        |.|.::...:..| |:.:..||.||...||..:|||....|..||::|.|:|.
Mouse   208 ------------VSNGISGLLDSIN-ARDVSVKIFEDFAQSWYWILVALGVALALSLLFILLLRL 259

  Fly   328 LSAPILWFSIFGVLIGLLVGIYFSVKQY-IHWENTPTVPVHGLNLH-STVKNVLQNQNTWLYLSI 390
            ::||::...|.|||..|..|||...:|| :..:...::...|...: |..::|   :.|||...|
Mouse   260 VAAPLVLLLIVGVLAVLAYGIYHCWQQYQVFRDKGASITQLGFTTNFSAYQSV---KETWLAALI 321

  Fly   391 FVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAIGVGLYL 455
            .:.|...::||::|.||:||||||||.||.|:||..::||:|:|:.:::|.:..|.:.....|||
Mouse   322 VLAVLEGILLLMLIFLRQRIRIAIALLKEASRAVGQMMSTMFYPLVTFVLLVICIGYWAVTALYL 386

  Fly   456 GSIGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQNRNPCLN 520
            .:.|.|.:     :..:...:|..  ||...:|.|    |.|       ...|.|      .|.|
Mouse   387 ATSGQPQY-----IYWASNTSTPG--CENVPVNMT----CDP-------MAPLNS------SCPN 427

  Fly   521 TTCSFDSINNPIEIKWAIF----YNVFGFLWLSFFISAFSYMVLASTFARWYWTF-KKRDVPYFT 580
            ..|.|...:.....:.::|    |.|.|..|...::.|....|||..||.:||.| |.||:|.|.
Mouse   428 LKCVFKGYSTTGLAQRSLFNLQIYGVLGLFWTVNWVLALGQCVLAGAFASFYWAFHKPRDIPTFP 492

  Fly   581 LTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCFFWLLETF 645
            |:.||.:|..||.|::|||:|||::|::.|::||||..||:...|.|.|.|:||.:|..|.||.|
Mouse   493 LSSAFIRTLRYHTGSLAFGALILSLVQIARVILEYIDHKLRGSQNPVARCIICCFKCCLWCLEKF 557

  Fly   646 LKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAGAGASTYY 710
            :||||||||||.||:|||||.||.::|.|:|||.||||.||:|||.|.|..|||:..|.|..:::
Mouse   558 IKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNVLRVVVLDKVTDLLLFFGKLLVVGGVGVLSFF 622

  Fly   711 FLD----------NNPSIIRLNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCERND 765
            |..          .||:   |||..:|....::.|::|.|.||.|:...|||||||||||.||||
Mouse   623 FFSGRIKGLGKDFENPN---LNYYWLPIMTSIMGAYVIASGFFSVFGMCVDTLFLCFLEDLERND 684

  Fly   766 GSPEKPFFMSKQLMKILGKKNNLP 789
            ||.|:|::|.|.|:|||||||..|
Mouse   685 GSQERPYYMPKALLKILGKKNEAP 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	152/368 (41%)
Slc44a4	XP_006524948.1	Choline_transpo	321..681	CDD:367975	159/386 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1691
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11359
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1648
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53694
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm43913
orthoMCL	1	0.900	-	-		OOG6_100798
Panther	1	1.100	-	-	O	PTHR12385
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2467
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870