DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl2 and Slc44a2

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	XP_011240895.1	Gene:	Slc44a2 / 68682	MGIID:	1915932	Length:	733	Species:	Mus musculus

Alignment Length:	794	Identity:	257/794 - (32%)
Similarity:	394/794 - (49%)	Gaps:	123/794 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCG 75
            :|.|.:||..|.||.. :|.||||.|.:|..|.:.|:..:...|..:||..|::.||||....||
Mouse    33 FGTPQKYDPTFKGPIY-NRGCTDVICCVLLFLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCG 96

  Fly    76 MDSGVLN--KKNLFFFDLNQCIDPLVPIT-GCDTPQVCVETCPRETFVWDTMKDKQSFAELHSRL 137
             ..|..|  |..||:|::.:|.:|||.:. .|.|||:||:.||.......:.::.:.|.  :.:.
Mouse    97 -QKGTKNADKPFLFYFNIVKCANPLVLLEFHCPTPQICVKQCPDRYLTLLSARNTRDFD--YYKQ 158

  Fly   138 ICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCL--FEFSQGVCDYIPSFLLNGGRSR 200
            .|:     ...:....:.:.:...:|......|.|..:||.  ...|:||
Mouse   159 FCV-----PGFQNNKGVTEILRDGECPAVITPSKPLAQRCFPAIHASKGV--------------- 203

  Fly   201 RELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLNEAVIKEKMM 265
                ::.||.||         |:           ..:|.:..:.:  :::..::.|:.:
Mouse   204 ----LMVGNETT---------YE-----------DGHGARKNITD--LVEGAKKANKIL------ 236

  Fly   266 QTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYIALMRWLSA 330
                                  :|:.|..:|.||...||..:::.....:|.||::|.|:|:|:.
Mouse   237 ----------------------EARQLAMQIFEDYTVSWYWIIIGLVIAMVLSLLFIVLLRFLAG 279

  Fly   331 PILWFSIFGVLIGLLVGIYFSVKQY--IHWENTPTVPVHGLNLHSTVKNVLQNQNTWLYLSIFVG 393
            .::|..|..|::.|..||:....:|  :..|....|.:..|...:.::..|..:.||:...|.:.
Mouse   280 IMVWVMIVMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDLRVYLHLRQTWMAFMIILS 344

  Fly   394 VCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAIGVGLYLGSI 458
            :..|||:||:|.|||||.|||||.||.|:||..|:.::.:|:.::.|....||:.....::|.:.
Mouse   345 ILEVVIILLLIFLRKRILIAIALIKEASRAVGHVMCSLLYPLVTFFLLCLCIAYWASTSVFLSTS 409

  Fly   459 GDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQNRN-PCLNTT 522
            ....:::|           :|..|  |.:..|    |.||.|.          .:|.: .|....
Mouse   410 NTAVYKVV-----------DDTAC--PLLRKT----CNPETFP----------LRNESLQCPTAR 447

  Fly   523 CSFDSINNPIEIKWAI----FYNVFGFLWLSFFISAFSYMVLASTFARWYWTFKK-RDVPYFTLT 582
            |.|...........|:    .:|.|.|.||:.|:.|...:.||..||.:||..:| .|:|.|.|.
Mouse   448 CQFAFYGGESTYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWAMRKPDDMPAFPLF 512

  Fly   583 RAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCFFWLLETFLK 647
            .||.:...||.|::||||||||||::||::|||:.::||...|...:.::.|::|.||.||.|:|
Mouse   513 SAFGRALRYHTGSLAFGSLILAIVQIIRVMLEYLDQRLKAAQNKFAKFLMVCLKCCFWCLEKFIK 577

  Fly   648 FLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAGAGASTYYFL 712
            |||||||||.||:|.|||:||.::|.|:|||.:||..||:||||||.|.|||:....|...::|.
Mouse   578 FLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFF 642

  Fly   713 DNNPSIIR-----LNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCERNDGSPEKPF 772
            .:...|::     |||..||...|:|.::||...||.||...||||||||.||.||||||.|:|:
Mouse   643 THRIRIVQDTAPPLNYYWVPILTVIIGSYLIAHGFFSVYGMCVDTLFLCFCEDLERNDGSQERPY 707

  Fly   773 FMSKQLMKILGKKN 786
            |||.:|..||.|.|
Mouse   708 FMSPELRGILLKGN 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	144/364 (40%)
Slc44a2	XP_011240895.1	ABC_6TM_exporters	<258..>298	CDD:365789	12/39 (31%)
Slc44a2	XP_011240895.1	Choline_transpo	341..697	CDD:398290	153/382 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1691
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1648
Isobase	1	0.950	-	0	Normalized mean entropy	S3684
OMA	1	1.010	-	-		QHG53694
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm43913
orthoMCL	1	0.900	-	-		OOG6_100798
Panther	1	1.100	-	-	LDO	PTHR12385
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2467
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820