DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl2 and SLC44A2

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_001350540.1	Gene:	SLC44A2 / 57153	HGNCID:	17292	Length:	711	Species:	Homo sapiens

Alignment Length:	792	Identity:	257/792 - (32%)
Similarity:	388/792 - (48%)	Gaps:	121/792 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KYGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKC 74
            |:|.|.:||..|.||.. :|.|||:.|.:..:|.:.|:..:...|..:||..|::.||||....|
Human    11 KHGTPQKYDPTFKGPIY-NRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFC 74

  Fly    75 GMDSGVL--NKKNLFFFDLNQCIDPLVPIT-GCDTPQVCVETCPRETFVWDTMKDKQSFAELHSR 136
            | ..|..  ||..||:|::.:|..|||.:. .|.|||:|||.||.....:...:..:.|.  :.:
Human    75 G-QKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFE--YYK 136

  Fly   137 LICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCL--FEFSQGVCDYIPSFLLNGGRS 199
            ..|:     ...:....:.:.:....|....|.|.|..:||.  ....:||
Human   137 QFCV-----PGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYKGV-------------- 182

  Fly   200 RRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLNEAVIKEKM 264
                 ::.||.||         |:           ..:|.:..:.:         |.|...|.
Human   183 -----LMVGNETT---------YE-----------DGHGSRKNITD---------LVEGAKKA-- 211

  Fly   265 MQTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYIALMRWLS 329
                               ||..:|:.|..:|.||...||..:::.....:..||::|.|:|:|:
Human   212 -------------------NGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLA 257

  Fly   330 APILWFSIFGVLIGLLVGIYFSVKQY--IHWENTPTVPVHGLNLHSTVKNVLQNQNTWLYLSIFV 392
            ..::|..|..|::.|..||:....:|  :..|....|.:..|...:..:..|..:.|||...|.:
Human   258 GIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIIL 322

  Fly   393 GVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAIGVGLYLGS 457
            .:..|:|:||:|.|||||.|||||.||.|:||..|:.::.:|:.::.|....||:.....::|.:
Human   323 SILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLCLCIAYWASTAVFLST 387

  Fly   458 IGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQNRNPCLNTT 522
            ..:..:::.           :|..|...|      .:|.||.|        .|..::|. |.|..
Human   388 SNEAVYKIF-----------DDSPCPFTA------KTCNPETF--------PSSNESRQ-CPNAR 426

  Fly   523 CSFDSINNPIEIKWAI----FYNVFGFLWLSFFISAFSYMVLASTFARWYWTFKK-RDVPYFTLT 582
            |.|...........|:    .:|.|.|.||:.|:.|...:.||..||.:||..:| .|:|.|.|.
Human   427 CQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPLF 491

  Fly   583 RAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCFFWLLETFLK 647
            .||.:...||.|::|||:||||||::||::|||:.::||..:|...:.::.|::|.||.||.|:|
Human   492 SAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIK 556

  Fly   648 FLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAGAGASTYYFL 712
            |||||||||.||:|.|||:||.::|.|:|||.:||..||:||||||.|.|||:....|...::|.
Human   557 FLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFF 621

  Fly   713 DNNPSIIR-----LNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCERNDGSPEKPF 772
            .:...|::     |||..||...|::.::||...||.||...||||||||.||.||||||.|:|:
Human   622 THRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFCEDLERNDGSQERPY 686

  Fly   773 FMSKQLMKILGK 784
            |||.:|..||.|
Human   687 FMSPELRDILLK 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	142/363 (39%)
SLC44A2	NP_001350540.1	Choline_transpo	337..675	CDD:309592	142/363 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1679
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1599
Isobase	1	0.950	-	0	Normalized mean entropy	S3684
OMA	1	1.010	-	-		QHG53694
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm41863
orthoMCL	1	0.900	-	-		OOG6_100798
Panther	1	1.100	-	-	LDO	PTHR12385
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2467
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820