DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ctl2 and slc44a5a

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	XP_696562.6	Gene:	slc44a5a / 568158	ZFINID:	ZDB-GENE-070705-333	Length:	715	Species:	Danio rerio

Alignment Length:	808	Identity:	276/808 - (34%)
Similarity:	398/808 - (49%)	Gaps:	130/808 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCG 75
            ||||.::|..|.|| ..:|.||||.|.:|||:.:.|:..:...|..:||..|::.||||..:.||
Zfish    12 YGEPRKFDPTFRGP-VYNRGCTDVLCCVLFVIVILGYIALGTVAWIHGDPRKVIYPTDSTGQFCG 75

  Fly    76 MDSGVLNKKN--LFFFDLNQCIDPLVPIT-GCDTPQVCVETCPRETFVWDTMKDKQSFAELH--- 134
             ..|..|.|.  ||:|::.:|..|.|.|. .|.|.|:||..||.....:..|:....|.:.|
Zfish    76 -QKGTPNAKKAILFYFNILKCASPAVLINLQCPTTQMCVSKCPDRFATYTDMQLLYRFNKSHWDY 139

  Fly   135 SRLICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCLFEFSQGVCDYIPSFLLNGGRS 199
            .:..|....:..|    ..:...:....|....:.|.|||:||           .|.|:...|
Zfish   140 YKQFCKPGFNNPQ----KSVAQVLRDEDCPSMIVPSRPFLQRC-----------FPDFITRNG-- 187

  Fly   200 RRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLNEAVIKEKM 264
                                          .|.|                     .|:...|:.:
Zfish   188 ------------------------------TLTV---------------------ANKTAFKDAL 201

  Fly   265 MQTDTRLAKLVGNM--VAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYIALMRW 327
               ||  |:.|..:  .|:.....::|:.:|.|||||..:.|..:::..|..||.|||:|.|:|:
Zfish   202 ---DT--ARSVTELRDAANGITSIHEAKEVGMKIVEDYASCWYWIVIGLFIALVISLIFILLLRF 261

  Fly   328 LSAPILWFSIFGVLIGLLVGIYFSVKQYIHWE-----NTP--TVPVHGLNLHSTVKNVLQNQNTW 385
            .:..:|||.||.|::.:..||:     :.:||     .||  .|.:..:...:.:...||...||
Zfish   262 TAGFLLWFIIFAVILLVAYGIW-----HCYWEFAVLRETPGADVTISDIGFQTDLHVYLQLSQTW 321

  Fly   386 LYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAIG 450
            |...:.:|:....|:|::|.||||:||||||.:|||:|:|.::|.:|:||.:::|....|::...
Zfish   322 LVFMVTLGLTEASIVLMLIFLRKRVRIAIALLREGSRAISYIMSALFYPIITFVLLAICISYWAM 386

  Fly   451 VGLYLGSIGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQNR 515
            ..|:|.|.||..:::.     ||          .|...| ...:|.||.|.:   ..:|
Zfish   387 TALFLASSGDAVYKVA-----SG----------NPNCKY-ANQTCSPESFNR---TNIT------ 426

  Fly   516 NPCLNTTCSFDSINNPIEIKWAIFY----NVFGFLWLSFFISAFSYMVLASTFARWYWTFKK-RD 575
            ..|....|.|............||.    |:..||||..|..|.....:|..||.:||..:| .|
Zfish   427 KQCPGAQCLFAFYGGESLYHRYIFILQLCNLLVFLWLVNFTIALGQCTVAGAFASYYWARRKPAD 491

  Fly   576 VPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCFFW 640
            :|...:..:|.:...||.|::||||||||:|:|||::|||:..|||...||..|.:|||::|.||
Zfish   492 IPPCPVFSSFSRALRYHTGSLAFGSLILAVVQLIRVILEYLDHKLKGAHNAFARFLLCCLKCCFW 556

  Fly   641 LLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAGAG 705
            .||.|::|:|||||||.||:|||||:||.::|.|:|||.:||..||:|||||.||.|||:....|
Zfish   557 CLERFIRFMNRNAYIMIAIYGKNFCTSAREAFYLLMRNVVRVAVLDKVTDFLLFLGKLLIAGSVG 621

  Fly   706 ASTYYFLDNNPSIIR-----LNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCERND 765
            ...::.......||:     |||..||...|::.::||...||.||:..||||||||.||.||||
Zfish   622 VIAFFLFTRKIPIIQEEVPVLNYYCVPLLTVILGSYLIAHSFFSVYAMCVDTLFLCFCEDLERND 686

  Fly   766 GSPEKPFFMSKQLMKILGKKNNLPPRQR 793
            |:..||||||..|.:||||....|.:.|
Zfish   687 GTTAKPFFMSPGLKRILGKAEQSPKKSR 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	148/363 (41%)
slc44a5a	XP_696562.6	Choline_transpo	335..682	CDD:282384	152/371 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1629
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1547
OMA	1	1.010	-	-		QHG53694
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm24498
orthoMCL	1	0.900	-	-		OOG6_100798
Panther	1	1.100	-	-	O	PTHR12385
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2467
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910