DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl2 and slc44a5b

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	XP_009302125.1	Gene:	slc44a5b / 558142	ZFINID:	ZDB-GENE-081105-4	Length:	741	Species:	Danio rerio

Alignment Length:	814	Identity:	275/814 - (33%)
Similarity:	410/814 - (50%)	Gaps:	126/814 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCG- 75
            |||.::|..|.||..: |.||||.|.::||:.:.|:..:...|..:||..|::.||||:.:.||
Zfish    14 GEPHKFDPTFRGPVHK-RGCTDVLCCVIFVIVILGYIVLGTVAWMHGDPRKVVYPTDSYGQFCGQ 77

  Fly    76 MDSGVLNKKNLFFFDLNQCIDPLVPIT-GCDTPQVCVETCPRE--TFV---WDTMKDKQSFAELH 134
            .::...||..||:|::.||.:|.|.|. .|.|.|:||..||..  |::   :...::|.|:
Zfish    78 QETPNANKAILFYFNILQCANPSVLINLQCPTTQLCVSKCPDRFATYIDMQYSYRRNKGSW---- 138

  Fly   135 SRLICLSEEHKAQI------RTKSDIQDAINQNQCARWYIKSAPFLKRCLFEFSQGVCDYIPSFL 193
                    |:..|.      .....|...:....|....:.|.|||:||           .|.|:
Zfish   139 --------EYYKQFCKPGFNNPDKPISQVLRDEDCPSMIVPSRPFLQRC-----------FPDFI 184

  Fly   194 LNGGRSRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGK-QTPVDEEPIIQCKRRLNE 257
            ...|                          .:|.|........:|| ::.||          |.:
Zfish   185 TRNG--------------------------TLTVANQTSFKDGHGKIRSVVD----------LRD 213

  Fly   258 AVIKEKMMQ--TDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLI 320
            |..|...||  |::.:..|:            ||:.:|.||.||..:||..:|:....:::.||:
Zfish   214 AANKVTAMQQGTESGITSLL------------DAKEVGTKIFEDYASSWFWILIGLVISMLVSLV 266

  Fly   321 YIALMRWLSAPILWFSIFGVLIGLLVGIYFSVKQYIHWENTP--TVPVHGLNLHSTVKNVLQNQN 383
            :|.|:|:.:..:.|..||||:..:..||:....:|...:..|  .|.:..:...:..:..||...
Zfish   267 FILLLRFTAGVLFWLVIFGVIAAVGYGIWHCYWEYSSLKGKPDSDVTISDIGFQTDFRVYLQLSQ 331

  Fly   384 TWLYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFA 448
            |||.....:.|...:|:|::|.||.|:||||||.||||||:..::||:|:||.:::|....||:.
Zfish   332 TWLIFMTSLAVIEAIIILVLIFLRNRVRIAIALLKEGSKAIGCIMSTLFYPIITFLLLALCIAYW 396

  Fly   449 IGVGLYLGSIGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQ 513
            ....::|.|.|:..::::.        |..||       .|| ..:|.||.|.|....:|
Zfish   397 AVTAVFLASSGEAVYKVMS--------TLPDC-------KYT-NLTCDPETFSQSNVTKL----- 440

  Fly   514 NRNPCLNTTCSFDSINNPIEIKWAIFY----NVFGFLWLSFFISAFSYMVLASTFARWYWTFKK- 573
                |..:.|:|............||.    |:..||||..|..|.....||..||.:||..:|
Zfish   441 ----CPGSQCTFAFYGGESLYHRYIFVLQLCNLLVFLWLVNFTIALGQCTLAGAFAAYYWALRKP 501

  Fly   574 RDVPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCF 638
            .|:|...|..:|.:...||.|::|||:|||:||:.||::|||:..|||...||.||.:|||::|.
Zfish   502 ADIPPCPLASSFGRALRYHTGSLAFGALILSIVQFIRIILEYLDHKLKGAHNAFTRFLLCCLKCC 566

  Fly   639 FWLLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAG 703
            ||.||.|:||:|||||||.:|:|||||:||.|:|.|:|||.:||..||:|||||.||.|||::..
Zfish   567 FWCLEHFIKFMNRNAYIMISIYGKNFCTSARDAFFLLMRNVMRVAVLDKVTDFLLFLGKLLISGS 631

  Fly   704 AGASTYYFLDNNPSIIR-----LNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCER 763
            .|...::|......:|:     |||..||...|:..:::|...||.||:..|||||||||.|.|:
Zfish   632 VGVLAFFFFTRQIPVIQEEVPSLNYYWVPLLTVIFGSYMIAHGFFNVYAMCVDTLFLCFLLDLEK 696

  Fly   764 NDGSPEKPFFMSKQLMKILGKKNNLPPRQ-RRGK 796
            ||||..:|::|...|..||.|||...|:: :||:
Zfish   697 NDGSATRPYYMCSSLRAILNKKNQKRPKETKRGR 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	151/363 (42%)
slc44a5b	XP_009302125.1	Choline_transpo	340..694	CDD:282384	156/378 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1629
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1547
OMA	1	1.010	-	-		QHG53694
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm24498
orthoMCL	1	0.900	-	-		OOG6_100798
Panther	1	1.100	-	-	LDO	PTHR12385
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2467
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870