DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl2 and slc44a4

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_956707.1	Gene:	slc44a4 / 393385	ZFINID:	ZDB-GENE-040426-1371	Length:	723	Species:	Danio rerio

Alignment Length:	808	Identity:	267/808 - (33%)
Similarity:	401/808 - (49%)	Gaps:	115/808 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ESVELMNKYGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPT 67
            |..:..::||.|.:||..|.||..: |||||:.|.:||:|.:.|:..:...|...||...:|.|.
Zfish     7 EEEQNSSEYGAPAQYDPTFNGPIHK-RSCTDIICCVLFMLVITGYMVVGILAWLYGDPRHVLYPR 70

  Fly    68 DSFNRKCGMDSGVLNKKNLFFFDLNQCIDP----LVPITG--CDTPQVCVETCPRETFVWDTMK- 125
            :|....||:... .||.::.:||:.:|...    ...:.|  |.|.||||.:||...:....:.
Zfish    71 NSTGMFCGIGQN-QNKPSVLYFDILKCATATNIMAAALQGLQCPTTQVCVSSCPSGFWALSPLAY 134

  Fly   126 -DKQSFAELHSRLICLSEEHKAQIR-TKSDIQDAINQNQCARWYIKSAPFLKRCLFEFSQGVCDY 188
             .....|:...:.:|:.   ..|:: |...:.:.||:..|..:|..:...|.|||  .|.|...|
Zfish   135 LPNAKPADYFQQELCVP---SLQLKDTTYTVMEIINKELCPYYYTPTTSVLDRCL--PSLGGSAY 194

  Fly   189 IPSFLLNGGRSRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKR 253
            .||             .:|.|.:                     :|..:..||
Zfish   195 NPS-------------NIPANFS---------------------LPGLSINQT------------ 213

  Fly   254 RLNEAVIKEKMMQTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVAS 318
                              ...:.|..:...|..| .:.:|.:|.||...:|..::......:|.|
Zfish   214 ------------------LSTIANATSDLTNSFN-MKDVGLRIFEDFAKTWQWIVAGLVIAMVVS 259

  Fly   319 LIYIALMRWLSAPILWFSIFGVLIGLLVGIYFSVKQYIHWENTPTVPVHGLNLHSTVKNVLQNQN 383
            ::::.|:|:.:..::|..|||||.....||::....|:...:: .:....:...:.|:..||.::
Zfish   260 VLFLLLLRFTAPVLIWILIFGVLAVGAFGIWYCYNDYMSLASS-NLTFSNVGFTTNVQVYLQVRD 323

  Fly   384 TWLYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFA 448
            |||...|.:.:...|::|.:|.||.||.|||||.:|.|||:..::||:.:|:.:::|.:..:::.
Zfish   324 TWLAFLIILCIVEAVLILALIFLRTRILIAIALIQETSKALGHMMSTLLYPVVTFVLLLVCVSYW 388

  Fly   449 IGVGLYLGSIGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQ 513
            ....|||.:.|.|.:::|...|..|     ||      .|.....:|.|:.|.   |.|.:|
Zfish   389 GITALYLATSGAPIYKVVALNTTQG-----DC------SNIQANQTCDPQTFN---SSRYSS--- 436

  Fly   514 NRNPCLNTTCSFDSINNPIEIKWAIF----YNVFGFLWLSFFISAFSYMVLASTFARWYWTFKK- 573
                |.:..|.|.:.|.....:..:|    |||..|||...|:.|..:..||..||.:||.|.|
Zfish   437 ----CPSARCVFINYNTEGLFQRNLFNLQIYNVVAFLWCVNFVIALGHCTLAGAFASYYWAFSKP 497

  Fly   574 RDVPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCF 638
            .|:|.|.||::|.:...||:|::|||:|||.:|:::|::|||:..|.|...|...|.::||::|.
Zfish   498 ADIPTFPLTQSFMRALRYHVGSLAFGALILTLVQIVRIILEYLDHKFKAAQNPCARFLMCCLKCC 562

  Fly   639 FWLLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAG 703
            ||.||.|:||:|||||||.||:|||||.||.::|.|:|||.:|||.||:|||.|.|..|||:..|
Zfish   563 FWCLEKFIKFINRNAYIMIAIYGKNFCVSAKNAFFLLMRNIVRVVVLDKVTDLLLFFGKLLVVGG 627

  Fly   704 AGASTYYFLD-------NNPSIIRLNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDC 761
            .|...::|..       |......|||..:|...||..|:||...||.||:..|||||||||||.
Zfish   628 IGVLAFFFFSGRIQLPGNTFQTAALNYYWMPIITVVFGAYLIAHGFFSVYNMGVDTLFLCFLEDL 692

  Fly   762 ERNDGSPEKPFFMSKQLMKILGKKNNLP 789
            ||||||.|||:||||.|||||.|||..|
Zfish   693 ERNDGSAEKPYFMSKNLMKILNKKNKQP 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	149/365 (41%)
slc44a4	NP_956707.1	UPF0182	<276..>357	CDD:304904	26/81 (32%)
slc44a4	NP_956707.1	Choline_transpo	329..692	CDD:282384	154/383 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1629
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11359
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1547
OMA	1	1.010	-	-		QHG53694
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm24498
orthoMCL	1	0.900	-	-		OOG6_100798
Panther	1	1.100	-	-	O	PTHR12385
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2467
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	14.010