DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl2 and Slc44a5

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	XP_017446494.1	Gene:	Slc44a5 / 365962	RGDID:	1564620	Length:	713	Species:	Rattus norvegicus

Alignment Length:	820	Identity:	257/820 - (31%)
Similarity:	404/820 - (49%)	Gaps:	146/820 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TESVELMNK-YGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLV 65
            :||.|..:: .|:|.|||.:|.||..: ||.|||.|.::||||:.|:..:...|..:||..|:..
  Rat     4 SESTEFEDQDLGDPRRYDPDFQGPTTK-RSSTDVMCCMIFVLFIMGYILLGLLAWVHGDPRKMAY 67

  Fly    66 PTDSFNRKCGMDSGV--LNKKNLFFFDLNQCIDPLVPITG--------CDTPQVCVETCPRETFV 120
            ||||..:.|| ..|.  .||..||:|::.:|       ||        |.|.|:||..||.....
  Rat    68 PTDSQGQFCG-QKGTPNENKTVLFYFNIFRC-------TGTSMMLRLQCSTTQICVSRCPERFLT 124

  Fly   121 WDTM----KDKQSFAELHSRLICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCLFEF 181
            :..|    |:.:::.|.: |..|     |||.|....:.|.::...|......|.|||:||:.:|
  Rat   125 YVDMQILNKEDKNYWEYY-RQFC-----KAQARPVETLADLLSSGDCPLAVYPSRPFLQRCVPDF 183

  Fly   182 SQGVCDYIPSFLLNGGRSRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEE 246
            |                      .:.||.|...:|..:               ...|::..|.|
  Rat   184 S----------------------AINGNLTLGSRMHFE---------------DGGGQKRTVVE- 210

  Fly   247 PIIQCKRRLNEAVIKEKMMQTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVAC 311
                    |.||             |..:.:::        ||:.:|.|::||...||..:|:..
  Rat   211 --------LREA-------------ASGISDVI--------DARAIGLKVLEDYSTSWKWILIGL 246

  Fly   312 FCTLVASLIYIALMRWLSAPILWFSIFGVLIGLLVGIYFSVKQYIHWENTP--TVPVHGLNLHST 374
            ...:..|..::.|:|:.:..:.||.|||||..:..||::...:|...:..|  .:.::|:.:.:.
  Rat   247 TIAMALSWTFLVLLRFTAGFLFWFFIFGVLGIIGYGIWYCFLEYNSIQQKPQSAIWMYGIGIQTR 311

  Fly   375 VKNVLQNQNTWLYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWI 439
            :......:.||..:.|.:....|||::::|.||.||::||.|.||||||:..:.|.:.:|..::|
  Rat   312 LNMFFHLKETWFSMMIILSAIEVVIIIVLIFLRTRIQVAIILLKEGSKAIGYLPSALVYPFLTFI 376

  Fly   440 LFIAAIAFAIGVGLYLGSIGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQ-- 502
            |....|::.....::|.:.|.|.|:::        |...:|:.|..|        |.||:|..
  Rat   377 LLSICISYWAVTAVFLATSGVPIFKVM--------VPEGECIHEDEA--------CDPEIFPNTD 425

  Fly   503 --------YCSVRLTSFFQNRNPCLNTTCSFDSINNPIEIKWAIFYNVFGFLWLSFFISAFSYMV 559
                    .|:.   :|:..|:...|...:|.            .||:|.||||..|:.|.....
  Rat   426 IPKACPGASCNF---AFYGGRSMYHNYIATFQ------------LYNLFAFLWLINFVIALGQCA 475

  Fly   560 LASTFARWYWTFKK-RDVPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKY 623
            ||..||.:||..:| .|:|.:.|..||.:...||.|::||||||||.|::.::::||:..:|||.
  Rat   476 LAGAFASYYWAMRKPEDIPRYPLFTAFGRAVRYHTGSLAFGSLILAFVQMFKVIVEYLDRRLKKA 540

  Fly   624 DNAVTRAILCCMRCFFWLLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQV 688
            .|:..:.:.||:||.||.||..:||||||||||.|::|||||.|..|:|.|:|||.|:|...|:|
  Rat   541 QNSAAQFLHCCLRCCFWCLEKMVKFLNRNAYIMIALYGKNFCESTRDAFYLLMRNILKVKVTDEV 605

  Fly   689 TDFLFFLSKLLLTAGAGASTY-YFLDNNPSIIR----LNYIAVPTTVVVIAAFLITSVFFGVYST 748
            |.|:..|.|:|::...|...: .|.:....|:.    |||..||...:|..::||...||.|||.
  Rat   606 TYFVLLLGKVLVSGIVGVLAFLLFTERLHEIVEGPTSLNYYWVPFLTLVFGSYLIAHGFFSVYSM 670

  Fly   749 AVDTLFLCFLEDCERNDGSPEKPFFMSKQLMKILGKKNNL 788
            .|:|:|:|||||.|.|:|||.:|:|::..||.:|.:::.:
  Rat   671 CVETIFICFLEDLETNEGSPSRPYFVTPTLMNVLVERDKI 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	136/369 (37%)
Slc44a5	XP_017446494.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1685
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1623
OMA	1	1.010	-	-		QHG53694
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm46001
orthoMCL	1	0.900	-	-		OOG6_100798
Panther	1	1.100	-	-	LDO	PTHR12385
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880