DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl2 and Slc44a2

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	XP_006242711.1	Gene:	Slc44a2 / 363024	RGDID:	1309680	Length:	711	Species:	Rattus norvegicus

Alignment Length:	807	Identity:	258/807 - (31%)
Similarity:	398/807 - (49%)	Gaps:	122/807 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ESVELMNKYGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPT 67
            :|.....|:|.|.:||..|.||.. :|.|||:.|.:|..|.:.|:..:...|..:||..|::.||
  Rat     4 DSQHYYGKHGTPQKYDPTFKGPIY-NRGCTDIICCVLLFLAIVGYVAVGIIAWTHGDPRKVIYPT 67

  Fly    68 DSFNRKCGMDSGVLN--KKNLFFFDLNQCIDPLVPIT-GCDTPQVCVETCPRETFVWDTMKDKQS 129
            ||....|| ..|..|  |..||:|::.:|..|||.:. .|.|||:||:.||.....:.:.::.:.
  Rat    68 DSRGEFCG-QKGTKNADKPFLFYFNIVKCASPLVLLEFHCPTPQICVKQCPDRYLTFLSARNSRD 131

  Fly   130 FAELHSRLICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCL--FEFSQGVCDYIPSF 192
            |.  :.:..|:     ...:....:.:.:...:|....|.|.|..:||.  ...|:||
  Rat   132 FD--YYKQFCV-----PGFKNNKGVAEVLRDGECPAVIIPSKPLAQRCFPAIHASKGV------- 182

  Fly   193 LLNGGRSRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLNE 257
                        ::.||.||         |:             :|..|..:...:::..::.|:
  Rat   183 ------------LMVGNETT---------YE-------------DGHGTRKNVTDLVEGAKKANK 213

  Fly   258 AVIKEKMMQTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYI 322
            .:                            :|:.|..:|.||...||..:::.....::.||::|
  Rat   214 VL----------------------------EARQLAMQIFEDYTVSWYWIVIGLVIAMLLSLMFI 250

  Fly   323 ALMRWLSAPILWFSIFGVLIGLLVGIYFSVKQY--IHWENTPTVPVHGLNLHSTVKNVLQNQNTW 385
            .|:|:|:..::|..|..|::.|..||:....:|  :..|....|.:..|...:.::..|..:.||
  Rat   251 VLLRFLAGVMVWVMIVMVILVLGYGIFHCYAEYSRLRGEAGSDVSLVDLGFQTDLRVYLHLRQTW 315

  Fly   386 LYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAIG 450
            :...|.:.:..|||:||:|.|||||.|||||.||.|:||..|:.::.:|:.::.|....||:...
  Rat   316 MAFMIILSILEVVIILLLIFLRKRILIAIALIKEASRAVGHVMCSMLYPLVTFFLLCLCIAYWAS 380

  Fly   451 VGLYLGSIGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQNR 515
            ..::|.:.....:::|           :|..|.      .:|.:|.||.|.          ....
  Rat   381 TSVFLSTSNVAVYKIV-----------DDTPCP------LLGKTCNPETFP----------LNES 418

  Fly   516 NPCLNTTCSFDSINNPIEIKWAI----FYNVFGFLWLSFFISAFSYMVLASTFARWYWTFKK-RD 575
            ..|.|..|.|...........|:    .:|.|.|.||:.|:.|...:.||..||.:||..:| .|
  Rat   419 RQCPNGRCQFAFYGGESTYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWAMRKPDD 483

  Fly   576 VPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCFFW 640
            :|.|.|..||.:...||.|::||||||||||::||::|||:.::||...|...:.::.|::|.||
  Rat   484 MPAFPLFSAFGRALRYHTGSLAFGSLILAIVQIIRVMLEYLDQRLKAAQNKFAKFLMVCLKCCFW 548

  Fly   641 LLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAGAG 705
            .||.|:||||||||||.||:|.|||:||.::|.|:|||.:||..||:||||||.|.|||:....|
  Rat   549 CLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVG 613

  Fly   706 ASTYYFLDNNPSIIR-----LNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCERND 765
            ...::|..:...|::     |||..||...|:|.::||...||.||...||||||||.||.||||
  Rat   614 ILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIIGSYLIAHGFFSVYGMCVDTLFLCFCEDLERND 678

  Fly   766 GSPEKPFFMSKQLMKILGKKNNLPPRQ 792
            ||.|:|:|||.:|..||.|.::...:|
  Rat   679 GSQERPYFMSPELKDILLKGSSQAGKQ 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	143/363 (39%)
Slc44a2	XP_006242711.1	Choline_transpo	320..675	CDD:398290	152/381 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1685
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1623
OMA	1	1.010	-	-		QHG53694
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm46001
orthoMCL	1	0.900	-	-		OOG6_100798
Panther	1	1.100	-	-	LDO	PTHR12385
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840