Protein Alignment Ctl2 and Slc44a4

DIOPT Version :10

• Sequence 1: NP_651670.1
• Gene: Ctl2 / 43440
• FlyBaseID: FBgn0039637
• Length: 796
• Species: Drosophila melanogaster
• Sequence 2: NP_997706.1
• Gene: Slc44a4 / 294255
• RGDID: 1303167
• Length: 707
• Species: Rattus norvegicus
• Alignment Length: 804
• Identity: 266/804 - (33%)
• Similarity: 397/804 - (49%)
• Gaps: 140/804 - (17%)

  Fly    11 YGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCG 75
            ||...:||.:|.|| .::|.|||:.|.:||::|:.|:..:...|...||..::|.|.:|....||
  Rat    11 YGNSAKYDPSFRGP-IKNRGCTDIICCVLFLVFILGYIVVGLVAWVYGDPRQVLYPRNSTGAYCG 74

  Fly    76 MDSGVLNKKNLFFFDLNQCIDPLVPIT------GCDTPQVCVETCPRETFVWDTMKDKQSFAELH 134
            :... .:|..:.:|::..|...:..|:      .|.||||||.:||:..:|.:..:...:..:::
  Rat    75 VGDN-KDKPYVLYFNILSCAAAINVISIAENGLQCPTPQVCVSSCPQTPWVVEGFQLSNTVGDVY 138

  Fly   135 S--RLICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCLFEFSQGVCDYIPSFLLNGG 197
            .  |..|:.......:     :.|::.:..|..:.:.|.|.|.||.
  Rat   139 KEYRNFCVPAVSPDMV-----VMDSLQKGLCPSFLLPSTPALGRCF------------------- 179

  Fly   198 RSRRELHMLPG-NATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLNEAVIK 261
                   .||. |.|...|:|.:
  Rat   180 -------PLPNINFTLPEQLQIN------------------------------------------ 195

  Fly   262 EKMMQTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYIALMR 326
                  :|.::|.:..::     .:.:|:.:..||.||...||..:|||....||.||::|.|:|
  Rat   196 ------NTTVSKGISGLL-----DSINARDVSVKIFEDFAQSWYWILVALGVALVLSLLFILLLR 249

  Fly   327 WLSAPILWFSIFGVLIGLLVGIYFSVKQYIHWENTPTVPVHGLNLHSTVKNVLQNQNTWLYLSIF 391
            .::||::...|.|||..|..|||...:||....: ..|.:..|...:.:......:.|||...|.
  Rat   250 LVAAPLVLLLIVGVLAVLAYGIYHCWQQYRELRD-QGVSITQLGFTANLSAYQNVKETWLAALII 313

  Fly   392 VGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAIGVGLYLG 456
            :.|...|:||::|.||:||||||||.||.|:||..::||:|:|:.:::|.:..|.:.....|||.
  Rat   314 LAVLEGVLLLMLIFLRQRIRIAIALLKEASRAVGQMMSTMFYPLVTFVLLVICIGYWAVTALYLA 378

  Fly   457 SIGDPSF-RMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQNRNPCLN 520
            :.|.|.: ..|...:..|        ||...:|.    ||.|       ...|.|      .|..
  Rat   379 TSGQPQYVYWVHNTSTPG--------CEKVLVNV----SCDP-------MAPLNS------SCPE 418

  Fly   521 TTCSFDSINNPIEIKWAIF----YNVFGFLWLSFFISAFSYMVLASTFARWYWTF-KKRDVPYFT 580
            ..|:|...::....:.::|    |.:.|..|...::.|....|||..||.:||.| |.||:|.|.
  Rat   419 LKCTFTGYSSSGLAQRSLFNLQIYGILGLFWTVNWVLALGQCVLAGAFASFYWAFHKPRDIPTFP 483

  Fly   581 LTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCFFWLLETF 645
            |:.||.:|..||.|::|||:|||.:|::.|::||||..||:...|.|.|.|:||.:|..|.||.|
  Rat   484 LSSAFIRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGSQNPVARCIICCFKCCLWCLEKF 548

  Fly   646 LKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAGAGASTYY 710
            :||||||||||.||:|||||.||.::|.|:|||.:|||.||:|||.|.|..|||:..|.|..:::
  Rat   549 IKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNVVRVVVLDKVTDLLLFFGKLLVVGGVGVLSFF 613

  Fly   711 FLD----------NNPSIIRLNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCERND 765
            |..          .||.   |||..:|....::.|::|.|.||.|:...|||||||||||.||||
  Rat   614 FFSGRIKGLGKDFKNPD---LNYYWLPIMTSIMGAYVIASGFFSVFGMCVDTLFLCFLEDLERND 675

  Fly   766 GSPEKPFFMSKQLMKILGKKNNLP 789
            ||.|:|::|.|.|:|||||||.:|
  Rat   676 GSQERPYYMPKALLKILGKKNEVP 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..762	CDD:461337	151/370 (41%)
Slc44a4	NP_997706.1	Choline_transpo	312..672	CDD:461337	158/387 (41%)