Protein Alignment Ctl2 and SLC44A1

DIOPT Version :10

• Sequence 1: NP_651670.1
• Gene: Ctl2 / 43440
• FlyBaseID: FBgn0039637
• Length: 796
• Species: Drosophila melanogaster
• Sequence 2: XP_006717090.1
• Gene: SLC44A1 / 23446
• HGNCID: 18798
• Length: 737
• Species: Homo sapiens
• Alignment Length: 814
• Identity: 214/814 - (26%)
• Similarity: 338/814 - (41%)
• Gaps: 219/814 - (26%)

  Fly    19 RNFTGPRQR------DRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCGM- 76
            ||.....:|      ||||||:|.||||:||..|..||..::|..|...:|:...||:...||.
Human    26 RNLEDSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQK 90

  Fly    77 --------DSGV--LNKKNLFFFD------LNQCIDPLVPITGCDTPQVCVETCPRETFVWDTMK 125
                    :||:  ..:|.:||.|      :|:.|..:.         :||..|||:..  .|:.
Human    91 NTKLEAIPNSGMDHTQRKYVFFLDPCNLDLINRKIKSVA---------LCVAACPRQEL--KTLS 144

  Fly   126 DKQSFAELHSRLICLSEEHKAQIRT--KSDIQDAINQNQCARWYIKSA---PFLKRCLFEFSQGV 185
            |.|.|||::...:|......::..|  ||.:       .|.:..:.::   ||..||
Human   145 DVQKFAEINGSALCSYNLKPSEYTTSPKSSV-------LCPKLPVPASAPIPFFHRC-------- 194

  Fly   186 CDYIPSFLLNGGRSRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQ 250
                                                                   .||:    |.
Human   195 -------------------------------------------------------APVN----IS 200

  Fly   251 CKRRLNEAVIKEKMMQTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTL 315
            |..:..||:|           ..:..|.|.|             :::..::.|..|:|..|..:|
Human   201 CYAKFAEALI-----------TFVSDNSVLH-------------RLISGVMTSKEIILGLCLLSL 241

  Fly   316 VASLIYIALMRWLSAPILWFSIFGVLIGLLVGIYFSVKQYIHWENTP--TVPVHGLNLHSTVKNV 378
            |.|:|.:.::|::|..::|.....|::|.|.|.......|.....:|  ||....|.:..
Human   242 VLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAE----- 301

  Fly   379 LQNQNTWLYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIA 443
             .|....|..:|...|..|::.|:::|:|||:.:.|||.....|....:...||.|.:::...:.
Human   302 -DNLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVL 365

  Fly   444 AIAFAIGVGLYLGSIGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRL 508
            ...:.|...|:||:.|.|             |..|                   :.|.::
Human   366 FWVYWIMTLLFLGTTGSP-------------VQNE-------------------QGFVEF----- 393

  Fly   509 TSFFQNRNPCLNTTCSFDSINNPIEIKWAIFYNVFGFLWLSFFISAFSYMVLASTFARWYWTFKK 573
                              .|:.|::..|  :|:|.|.:|:|.||.|...|.:|.....:|:|..|
Human   394 ------------------KISGPLQYMW--WYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDK 438

  Fly   574 RDVPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCF 638
            |::|:..:..:..:...|||||||.||.|:.:|::.|::|.|||.:||..:||..|.:|....|.
Human   439 RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLKSCICC 503

  Fly   639 FWLLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAG 703
            .|.||..|.:||:|||...||:..|||:||.|:|.:::.|.|||.|::.|.||:.||.|:|:...
Human   504 LWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVATINTVGDFMLFLGKVLIVCS 568

  Fly   704 AGASTYYFLDNNPSIIRLNY------IAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCE 762
            .|.:         .|:.|||      ..:|..:|.:.|||:...|..:|...||.|||||..|.:
Human   569 TGLA---------GIMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTK 624

  Fly   763 RNDGSPEKPFFMSKQLMKILGKKNNLPPRQRRGK 796
            .|||||.:.|:|.|.||:.:  :|:....:..||
Human   625 YNDGSPGREFYMDKVLMEFV--ENSRKAMKEAGK 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..762	CDD:461337	110/360 (31%)
SLC44A1	XP_006717090.1	Choline_transpo	312..622	CDD:461337	114/375 (30%)