Protein Alignment Ctl2 and SLC44A5

DIOPT Version :10

• Sequence 1: NP_651670.1
• Gene: Ctl2 / 43440
• FlyBaseID: FBgn0039637
• Length: 796
• Species: Drosophila melanogaster
• Sequence 2: XP_016856096.1
• Gene: SLC44A5 / 204962
• HGNCID: 28524
• Length: 726
• Species: Homo sapiens
• Alignment Length: 809
• Identity: 263/809 - (32%)
• Similarity: 398/809 - (49%)
• Gaps: 133/809 - (16%)

  Fly    11 YGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCG 75
            :|:|..||.:|.|| ..:||||||.|.::|:|.:.|:..:...|..:||..:...||||....||
Human    24 FGDPRTYDPDFKGP-VANRSCTDVLCCMIFLLCIIGYIVLGLVAWVHGDPRRAAYPTDSQGHFCG 87

  Fly    76 MDSGV--LNKKNLFFFDLNQCIDPLVPIT-GCDTPQVCVETCPRETFVWDTM-----KDKQSFAE 132
             ..|.  .||..||:|:|.:|..|.|.:. .|.|.|:||..||.:...:..|     |||..:.:
Human    88 -QKGTPNENKTILFYFNLLRCTSPSVLLNLQCPTTQICVSKCPEKFLTYVEMQLLYTKDKSYWED 151

  Fly   133 LHSRLICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCLFEFSQGVCDYIPSFLLNGG 197
            .  |..|     |...:....:...:..:.|......|.|||:||..:||
Human   152 Y--RQFC-----KTTAKPVKSLTQLLLDDDCPTAIFPSKPFLQRCFPDFS--------------- 194

  Fly   198 RSRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLNEAVIKE 262
                                                 ..||..|                  |..
Human   195 -------------------------------------TKNGTLT------------------IGS 204

  Fly   263 KMMQTD----TRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYIA 323
            |||..|    ||....:| :.|:..|...||:.||.|:.||...:|..:|:.....:|.|.|::.
Human   205 KMMFQDGNGGTRSVVELG-IAANGINKLLDAKSLGLKVFEDYARTWYWILIGLTIAMVLSWIFLI 268

  Fly   324 LMRWLSAPILWFSIFGVLIGLL-VGIYFSVKQYIHWENTPT--VPVHGLNLHSTVKNVLQNQNTW 385
            |:|:::..:.|..:.|| ||:: .||:...:||.:.:..|:  :.::.:.:.:.:....:.|.||
Human   269 LLRFIAGCLFWVFMIGV-IGIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFELQQTW 332

  Fly   386 LYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAIG 450
            ....|.:.:..|:::|::|.||.|||:||.|.||||||:..|.||:.:|..::||....|.:.:.
Human   333 FTFMIILCIIEVIVILMLIFLRNRIRVAIILLKEGSKAIGYVPSTLVYPALTFILLSICICYWVV 397

  Fly   451 VGLYLGSIGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQNR 515
            ..::|.:.|.|.::::   ...|.     |:.|    |.|    |.||:|         :..:..
Human   398 TAVFLATSGVPVYKVI---APGGH-----CIHE----NQT----CDPEIF---------NTTEIA 437

  Fly   516 NPCLNTTCSF-----DSINNPIEIKWAIFYNVFGFLWLSFFISAFSYMVLASTFARWYWTFKK-R 574
            ..|....|:|     .|:.:.. |.....||:|.||||..|:.|.....||..||.:||..|| .
Human   438 KACPGALCNFAFYGGKSLYHQY-IPTFHVYNLFVFLWLINFVIALGQCALAGAFATYYWAMKKPD 501

  Fly   575 DVPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCFF 639
            |:|.:.|..||.:...||.|::||||||:|::::.::||||:..:||:..|.:::.:.||:||.|
Human   502 DIPRYPLFTAFGRAIRYHTGSLAFGSLIIALIQMFKIVLEYLDHRLKRTQNTLSKFLQCCLRCCF 566

  Fly   640 WLLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAGA 704
            |.||..:||||||||||.||:|:|||.||.|:|||:|||.|:|...|:||.|:.||.|||:....
Human   567 WCLENAIKFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVAVTDEVTYFVLFLGKLLVAGSI 631

  Fly   705 GASTYYFLDNNPSII-----RLNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCERN 764
            |...:.|......:|     .|||..||...|:..::||...||.||:..|:|:|:||.||.|||
Human   632 GVLAFLFFTQRLPVIAQGPASLNYYWVPLLTVIFGSYLIAHGFFSVYAMCVETIFICFCEDLERN 696

  Fly   765 DGSPEKPFFMSKQLMKILGKKNNLPPRQR 793
            |||.|||:|::..|..||.||..:|.:|:
Human   697 DGSTEKPYFVTPNLHGILIKKQLVPQKQK 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..762	CDD:461337	142/365 (39%)
SLC44A5	XP_016856096.1	Choline_transpo	337..694	CDD:461337	147/382 (38%)