DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl2 and SLC44A5

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	XP_016856096.1	Gene:	SLC44A5 / 204962	HGNCID:	28524	Length:	726	Species:	Homo sapiens

Alignment Length:	809	Identity:	263/809 - (32%)
Similarity:	398/809 - (49%)	Gaps:	133/809 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCG 75
            :|:|..||.:|.|| ..:||||||.|.::|:|.:.|:..:...|..:||..:...||||....||
Human    24 FGDPRTYDPDFKGP-VANRSCTDVLCCMIFLLCIIGYIVLGLVAWVHGDPRRAAYPTDSQGHFCG 87

  Fly    76 MDSGV--LNKKNLFFFDLNQCIDPLVPIT-GCDTPQVCVETCPRETFVWDTM-----KDKQSFAE 132
             ..|.  .||..||:|:|.:|..|.|.:. .|.|.|:||..||.:...:..|     |||..:.:
Human    88 -QKGTPNENKTILFYFNLLRCTSPSVLLNLQCPTTQICVSKCPEKFLTYVEMQLLYTKDKSYWED 151

  Fly   133 LHSRLICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCLFEFSQGVCDYIPSFLLNGG 197
            .  |..|     |...:....:...:..:.|......|.|||:||..:||
Human   152 Y--RQFC-----KTTAKPVKSLTQLLLDDDCPTAIFPSKPFLQRCFPDFS--------------- 194

  Fly   198 RSRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLNEAVIKE 262
                                                 ..||..|                  |..
Human   195 -------------------------------------TKNGTLT------------------IGS 204

  Fly   263 KMMQTD----TRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYIA 323
            |||..|    ||....:| :.|:..|...||:.||.|:.||...:|..:|:.....:|.|.|::.
Human   205 KMMFQDGNGGTRSVVELG-IAANGINKLLDAKSLGLKVFEDYARTWYWILIGLTIAMVLSWIFLI 268

  Fly   324 LMRWLSAPILWFSIFGVLIGLL-VGIYFSVKQYIHWENTPT--VPVHGLNLHSTVKNVLQNQNTW 385
            |:|:::..:.|..:.|| ||:: .||:...:||.:.:..|:  :.::.:.:.:.:....:.|.||
Human   269 LLRFIAGCLFWVFMIGV-IGIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFELQQTW 332

  Fly   386 LYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAIG 450
            ....|.:.:..|:::|::|.||.|||:||.|.||||||:..|.||:.:|..::||....|.:.:.
Human   333 FTFMIILCIIEVIVILMLIFLRNRIRVAIILLKEGSKAIGYVPSTLVYPALTFILLSICICYWVV 397

  Fly   451 VGLYLGSIGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQNR 515
            ..::|.:.|.|.::::   ...|.     |:.|    |.|    |.||:|         :..:..
Human   398 TAVFLATSGVPVYKVI---APGGH-----CIHE----NQT----CDPEIF---------NTTEIA 437

  Fly   516 NPCLNTTCSF-----DSINNPIEIKWAIFYNVFGFLWLSFFISAFSYMVLASTFARWYWTFKK-R 574
            ..|....|:|     .|:.:.. |.....||:|.||||..|:.|.....||..||.:||..|| .
Human   438 KACPGALCNFAFYGGKSLYHQY-IPTFHVYNLFVFLWLINFVIALGQCALAGAFATYYWAMKKPD 501

  Fly   575 DVPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCFF 639
            |:|.:.|..||.:...||.|::||||||:|::::.::||||:..:||:..|.:::.:.||:||.|
Human   502 DIPRYPLFTAFGRAIRYHTGSLAFGSLIIALIQMFKIVLEYLDHRLKRTQNTLSKFLQCCLRCCF 566

  Fly   640 WLLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAGA 704
            |.||..:||||||||||.||:|:|||.||.|:|||:|||.|:|...|:||.|:.||.|||:....
Human   567 WCLENAIKFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVAVTDEVTYFVLFLGKLLVAGSI 631

  Fly   705 GASTYYFLDNNPSII-----RLNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCERN 764
            |...:.|......:|     .|||..||...|:..::||...||.||:..|:|:|:||.||.|||
Human   632 GVLAFLFFTQRLPVIAQGPASLNYYWVPLLTVIFGSYLIAHGFFSVYAMCVETIFICFCEDLERN 696

  Fly   765 DGSPEKPFFMSKQLMKILGKKNNLPPRQR 793
            |||.|||:|::..|..||.||..:|.:|:
Human   697 DGSTEKPYFVTPNLHGILIKKQLVPQKQK 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	141/364 (39%)
SLC44A5	XP_016856096.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1679
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1599
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53694
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm41863
orthoMCL	1	0.900	-	-		OOG6_100798
Panther	1	1.100	-	-	LDO	PTHR12385
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2467
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870