Protein Alignment Ctl2 and chtl-1

DIOPT Version :10

• Sequence 1: NP_651670.1
• Gene: Ctl2 / 43440
• FlyBaseID: FBgn0039637
• Length: 796
• Species: Drosophila melanogaster
• Sequence 2: NP_001367417.1
• Gene: chtl-1 / 180809
• WormBaseID: WBGene00018037
• Length: 773
• Species: Caenorhabditis elegans
• Alignment Length: 782
• Identity: 262/782 - (33%)
• Similarity: 395/782 - (50%)
• Gaps: 120/782 - (15%)

  Fly    29 RSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCGMD-SGVLN---KKNLFFF 89
            |.||||.|..||.:||.||..:|.:.|..||..:|:.||||..|:||:: .|..|   :..||:|
 Worm    87 RGCTDVFCCFLFFVFLCGWVVVAGFGIMWGDPQRLIYPTDSEFRRCGVNLEGSYNFSKRPYLFYF 151

  Fly    90 DLNQCIDPLVPITGCDTPQVCVETCPRETFVWDTMKDKQSFAELHSRL----ICLSEEHKAQIRT 150
            ||.:||.....:.||.|.|:||:.||...|.:..:: ..|.:|:.:::    .|..:..|..:.|
 Worm   152 DLTKCISYATALGGCQTTQLCVKECPSTYFSYLQLR-TASVSEIQNKMKSVVYCTDDVDKTTVTT 215

  Fly   151 KSDIQDAINQNQCARWYIKS--APFLKRCLFEFSQGVCDYIPSFLLNGGRSRRELHMLPGNATTE 213
            ...:|:.:.:.:|..:.:||  .|.|:||..|......|.:.: :||...|
 Worm   216 FQALQNLVQRGKCVSYTVKSVPVPVLQRCFPEAIFNAVDNVNN-VLNSSNS-------------- 265

  Fly   214 VQMQADVMYQKMTDAQALVVP---QANGKQTPVDEEPIIQCKRRLNEAVIKEKMMQTDTRLAKLV 275
                  :.|.|.|.....::|   |..|:.:.|            .::|::::
 Worm   266 ------LDYLKRTFGDDALIPQDIQITGQSSEV------------MKSVVEDQ------------ 300

  Fly   276 GNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYIALMRWLSAPILWFSIFGV 340
              .|.|             |::.||..:|...|:..|...:.|.|:..:||.|.:.|:|.||..|
 Worm   301 --PVTH-------------KVIHDLSQTWWQTLILIFAAGILSFIWTVIMRLLGSLIIWLSILIV 350

  Fly   341 LIGLLVGIYFSVKQYIHWENTPTV-PVHGLNLHSTVKNVLQNQNTWLYLSIFVGVCFVVILLLVI 404
            |:.|..|..||   ::.|....|. .:...:.|.......:...|||.::|...|..::.||:::
 Worm   351 LVALGFGAGFS---WLKWNTLKTTGAIDDYSFHPAFDAYFEMPTTWLVVAIATSVLLLIFLLVIL 412

  Fly   405 VLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAIGVGLYLGSIGDPSFRMVRQL 469
            .:|:||.||.||..|.|||:.|::||:.||:|.::|.|...|....:.::|.|.|.   .:.|..
 Worm   413 FIRQRISIACALISESSKAIGSMMSTLLFPLFPFLLHIGVFALWGSIAIWLASSGQ---EVCRLK 474

  Fly   470 TKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQNRNPCLNTTCSFDSINNPIE- 533
            ..:|:|......|:                    |:.::|.            |::..|....|
 Worm   475 ETNGQVYNTSTKCD--------------------CTAKVTG------------CTYVGIEKESET 507

  Fly   534 IKWAIFYNVFGFLWLSFFISAFSYMVLASTFARWYWTFKKR-DVPYFTLTRAFFQTAVYHLGTVA 597
            |.|...||:|.|.|||.|::|...:.||..||.:||...|| |||.|.:.||..:...|:||::|
 Worm   508 IFWLQVYNLFAFFWLSCFVTALGDIALAGAFASYYWARDKRHDVPTFPVIRALNRAIRYNLGSIA 572

  Fly   598 FGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCFFWLLETFLKFLNRNAYIMCAIHGK 662
            |||||:|||::||::||||..||.|..|...:..|.|::|.||.||.|.|||.:|||||.||:||
 Worm   573 FGSLIIAIVKIIRVLLEYIDHKLGKSQNKAVKWFLMCLKCCFWCLEVFFKFLTKNAYIMIAIYGK 637

  Fly   663 NFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAGAGASTYYFLDNNPSI-----IRLN 722
            ||.|||.|||.||.||.:|.|.:.:|...|.||.|.::|.|.|..::|:......:     :.|.
 Worm   638 NFFSSAKDSFLLITRNIVRTVVVHKVAGILLFLGKSMITLGMGILSFYYFSGRWVVEGVPKVDLY 702

  Fly   723 YIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCERNDGSPEKPFFMSKQLMKILGKKNN 787
            |..||..:|||.::.:..:||.||..||||.|:|||||.|:||||.|:|||||::|::|||.||:
 Worm   703 YYFVPIVIVVIGSYFMADLFFDVYEMAVDTTFICFLEDSEQNDGSLERPFFMSEKLLEILGNKND 767

  Fly   788 LP 789
            :|
 Worm   768 IP 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..762	CDD:461337	143/361 (40%)
chtl-1	NP_001367417.1	Choline_transpo	415..742	CDD:461337	143/361 (40%)