DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl2 and slc44a4

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	XP_017952306.1	Gene:	slc44a4 / 100489321	XenbaseID:	XB-GENE-485457	Length:	708	Species:	Xenopus tropicalis

Alignment Length:	821	Identity:	286/821 - (34%)
Similarity:	413/821 - (50%)	Gaps:	151/821 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NKYGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRK 73
            ::||||.:||.:|.||.:: |||||:.|.:||::||.|:..:...|...||..:::.|.:|....
Frog     4 DEYGEPAKYDPSFKGPIKK-RSCTDIICCVLFMVFLLGYMVVGILAWLYGDPRQVIYPRNSTGMY 67

  Fly    74 CGMDSGVLNKKNLFFFDLNQCIDPLVPITG------------CDTPQVCVETCPRETFVWDTMKD 126
            ||:... ..|.|:.::||.:|      |||            |.|.||||..||.: |.|  .|.
Frog    68 CGIGEN-QGKPNVLYYDLLKC------ITGTNILAAAMNGLQCPTTQVCVANCPAD-FKW--AKP 122

  Fly   127 KQSFAELHSRLICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCLFEFSQGVCDYIPS 191
            ..:.|:::.:..|....:..  .|...:.:...:..|..:.:.||.|..||   |......:..:
Frog   123 GSTPADVYLQEYCQPSINLT--NTALTVAEIAARELCPVFLVPSASFFNRC---FPGSNLSFPSN 182

  Fly   192 FLLNGGRSRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLN 256
            |.:||         |..|
Frog   183 FAING---------LSVN----------------------------------------------- 191

  Fly   257 EAVIKEKMMQTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIY 321
                     |:...::|..|.::..|     :.|.:|:||.||...||..::.|....:|.||::
Frog   192 ---------QSKDSISKAAGQILDSF-----NFQNVGKKIFEDFAKSWPWIITALVIAMVVSLLF 242

  Fly   322 IALMRWLSAPILWFSIFGVLIGLLVGIYFSVKQYIHWENTPTVPVHGLNLHSTVKNV-------- 378
            :.|:|:.:..::|..|.||:..:..|||....:|      .|:...|    .||.||
Frog   243 LILLRFTAGILVWVLIVGVIGVIGYGIYHCYMEY------DTLNKQG----ETVANVGFTFNLGV 297

  Fly   379 -LQNQNTWLYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFI 442
             .:.:.|||.:.|.:.|...::||:::.|||||.|||||.||.|||:..::|::|:|:.:::|.|
Frog   298 YFRVKETWLAILIVLAVIEAILLLVLLFLRKRILIAIALIKEASKAIGHIMSSLFYPLVTFVLLI 362

  Fly   443 AAIAFAIGVGLYLGSIGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVR 507
            ..:|:.....|||.:.|.|.:|:       ..|.|....||    |.|...:|.|..|    |..
Frog   363 VCVAYWGMTALYLATSGAPLYRI-------STVNTSVPGCE----NITGNETCNPMTF----SNA 412

  Fly   508 LTSFFQNRNPCLNTTCSFDSINNPIEIKWAIF----YNVFGFLWLSFFISAFSYMVLASTFARWY 568
            .||       |....|.|...||....:..:|    |||.||||...|:.|....|||.|||.:|
Frog   413 STS-------CKEARCIFYRYNNEGLFQTNLFNLQIYNVIGFLWCINFVIALGQCVLAGTFASYY 470

  Fly   569 WTF-KKRDVPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAIL 632
            |.| |.:|:|:|.:..:|.:|..||.|::|||:|||.||:|||::|||:..|||...|..||.:|
Frog   471 WAFHKPKDIPFFPVAESFMRTLRYHTGSLAFGALILTIVQLIRIILEYLDHKLKGAQNPCTRFLL 535

  Fly   633 CCMRCFFWLLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSK 697
            ||::|.||.||.|:||||||||||.|::|||||.||.::|.|:|||.:|||.||:|||.|.|..|
Frog   536 CCLKCCFWCLEKFIKFLNRNAYIMIAVYGKNFCVSAKNAFKLLMRNIVRVVVLDKVTDLLIFFGK 600

  Fly   698 LLLTAGAGASTYYFLDN-----NPSI--IRLNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFL 755
            |::..|.|...::|...     ||:.  ..|||..:|...|||.:::|:..||.||:..||||||
Frog   601 LIVVGGVGVLAFFFFSGRIPIPNPAFQSPALNYYWIPILTVVIGSYMISHGFFSVYNMCVDTLFL 665

  Fly   756 CFLEDCERNDGSPEKPFFMSKQLMKILGKKNNLPPRQRRGK 796
            |||||.||||||||||::|||.||.||.|||..|..:.:.|
Frog   666 CFLEDLERNDGSPEKPYYMSKSLMSILNKKNRPPKSEEKTK 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	162/365 (44%)
slc44a4	XP_017952306.1	Choline_transpo	310..672	CDD:367975	168/383 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1380
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11359
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1462
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm49084
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060