DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl2 and slc44a5

DIOPT Version :9

Sequence 1:	NP_651670.1	Gene:	Ctl2 / 43440	FlyBaseID:	FBgn0039637	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	XP_031755701.1	Gene:	slc44a5 / 100145179	XenbaseID:	XB-GENE-987953	Length:	725	Species:	Xenopus tropicalis

Alignment Length:	833	Identity:	282/833 - (33%)
Similarity:	408/833 - (48%)	Gaps:	168/833 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCG 75
            :|||.::|..|.||..: |.||||.|.::||:.:.|:..:...|..:||..|::.||||:.:.||
Frog    12 FGEPRKFDPKFKGPIGK-RHCTDVLCCIIFVVVILGYIALGVVAWIHGDPRKIIYPTDSYGQFCG 75

  Fly    76 MDSGV--LNKKNLFFFDLNQCIDPLVPIT-GCDTPQVCVETCPRETFVWDTMKDKQ------SFA 131
             ..|.  .||..|.:|::.:|..|:|.|. .|.|.|:||..|| :.|.  |..|.|      |:.
Frog    76 -QKGTPNENKTILMYFNILRCASPVVLINLQCPTTQLCVSKCP-DRFA--TYLDMQANRFNNSYW 136

  Fly   132 ELHSRLICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCLFEFSQGVCDYIPSFLLNG 196
            |.:.: .|.....|    .:..|.:.:....|....|.|.|||:||..:||
Frog   137 EYYKQ-FCKPGFDK----PRKSITEVLRDEDCPSMIIPSRPFLQRCFPDFS-------------- 182

  Fly   197 GRSRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLNEAVIK 261
                                                  ..||..|..            |:...|
Frog   183 --------------------------------------TRNGVLTVA------------NKTEFK 197

  Fly   262 EKMMQ----TDTRLAKLVGNMVAHFYNGTN-------DAQLLGEKIVEDLVNSWSIVLVACFCTL 315
            :.:.|    ||.|.|   .|.|....:||.       ||:.:|.||.||..:||..:|:|.|..:
Frog   198 DGIGQMRNVTDLRSA---ANHVTTTQHGTKSGINNVLDARSVGMKIFEDYASSWYWILIALFIAM 259

  Fly   316 VASLIYIALMRWLSAPILWFSIFGVLIGLLVGIYFSVKQYIHWENTP--TVPVHGLNLHSTVKNV 378
            |.||:::.|:|:.:....|..|.||:..:..||:....:|...:..|  .:.::.:.|.:..:..
Frog   260 VVSLLFLILLRFTAGVFFWIFIIGVIGVVGYGIWHCFWEYDSLKGVPGADLTIYDIGLQTDFRVY 324

  Fly   379 LQNQNTWLYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIA 443
            ||.:.|||...|.:.:..|:|:|::|.||.||||||||.:|||:|:..::||:|:||.::||...
Frog   325 LQLRQTWLAFMILLCIVEVIIILMLIFLRNRIRIAIALLQEGSRAIGYIMSTLFYPIITFILIAI 389

  Fly   444 AIAFAIGVGLYLGSIGDPSFRMV--RQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSV 506
            .|::.....:::.:.|:|.::::  :.|.|..::|                  |.||.|......
Frog   390 CISYWAVTAVFMATSGEPIYKVMANKTLCKYADIT------------------CIPETFNTTNVT 436

  Fly   507 RLTSFFQNRNPCLNTTCSFDSINNPIEIKWAIFY----------------NVFGFLWLSFFISAF 555
            ||         |....|:|            .||                |||.||||..|..|.
Frog   437 RL---------CPGAQCTF------------AFYGGESFYHQYILIFQLCNVFVFLWLVNFSIAL 480

  Fly   556 SYMVLASTFARWYWTFKK-RDVPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEK 619
            ....||..||.:||.||| .|:|...|..:|.:...||.|::|.||||||:|:.||::|||:..|
Frog   481 GQCTLAGAFASYYWAFKKPADIPACPLFSSFGRAIRYHTGSLALGSLILALVQFIRIILEYLDHK 545

  Fly   620 LKKYDNAVTRAILCCMRCFFWLLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVT 684
            ||...|:..:.||||::|.||.||.|:||:|||||||.||:|||||:||.|:|.|:|||.:||..
Frog   546 LKASQNSFAKFILCCLKCCFWCLEKFIKFMNRNAYIMIAIYGKNFCTSAKDAFFLLMRNVIRVAV 610

  Fly   685 LDQVTDFLFFLSKLLLTAGAGASTYYFL--------DNNPSIIRLNYIAVPTTVVVIAAFLITSV 741
            ||:|||||.||.|:.:|...|...::|.        |..|:   |||..||...|:|.::||...
Frog   611 LDKVTDFLLFLGKVFVTGSVGVLAFFFFTRKIPVLTDEAPA---LNYYWVPLLTVLIGSYLIAHG 672

  Fly   742 FFGVYSTAVDTLFLCFLEDCERNDGSPEKPFFMSKQLMKILGKKNNLPPRQRR 794
            ||.||:..||||||||.||.|||:||..||::||..|.:|||||..|..:.:|
Frog   673 FFSVYAMCVDTLFLCFCEDLERNNGSSSKPYYMSPNLHRILGKKEILSKKAKR 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl2	NP_651670.1	Choline_transpo	407..761	CDD:282384	152/380 (40%)
slc44a5	XP_031755701.1	Choline_transpo	336..693	CDD:398290	159/398 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1380
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1462
OMA	1	1.010	-	-		QHG53694
OrthoDB	1	1.010	-	-		D156581at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm49084
Panther	1	1.100	-	-	LDO	PTHR12385
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2467
SonicParanoid	1	1.000	-	-		X515
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110