DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yem and ubn2b

DIOPT Version :9

Sequence 1:	NP_001263054.1	Gene:	yem / 43439	FlyBaseID:	FBgn0005596	Length:	1101	Species:	Drosophila melanogaster
Sequence 2:	NP_001098410.1	Gene:	ubn2b / 561642	ZFINID:	ZDB-GENE-060503-768	Length:	1065	Species:	Danio rerio

Alignment Length:	1152	Identity:	269/1152 - (23%)
Similarity:	441/1152 - (38%)	Gaps:	244/1152 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SSKPTT---KTAKCIRIKLDLFETDSNKYPEFNYSRLLYLEKKKTKKLKQVSTTNGSASTDPFAD 103
            ::||.|   :..:.:|:.|.|.|.:..|..||||..|: ....:.:|..| ..|.....:|||||
Zfish    50 TAKPATDPGEPKRTVRLNLSLSEPNEQKSAEFNYGELI-TSSLQVRKAPQ-GLTPALDPSDPFAD 112

  Fly   104 ND---DDVARIVKELEAKYGNSYATGRGKSKKDDYRDIGMGYDESDSFIDNTEAYDEIIPEEAET 165
            .|   .:|..:.::.|:|||.:....| |.:..|..|||.||||:|.||||:|||||::|....|
Zfish   113 EDKERQEVEALARKFESKYGGAVKKKR-KDRMQDLIDIGYGYDETDPFIDNSEAYDELVPASLTT 176

  Fly   166 LEGGFYINCGALEFKNLTKKSYTTRTDAIIKMPERSRKRMVSSSSESSSSSSGDDDENDDGNNEE 230
            ..||||||.|.|:|:                         |:|.||      |:|...:..:.::
Zfish   177 KLGGFYINTGTLQFR-------------------------VASESE------GEDAGKESNHIKK 210

  Fly   231 DDESDSEDDSEENDESDSEDDSESESLEDEDSAATAKSSSKYKDNHQAK-------------RAK 282
            :.|.......::..:...|:....:....:...::.....|.|.....|             |.|
Zfish   211 EGEERVIKRRKKKQDGGLEEKKPRKFKVPKPGVSSLNRPEKKKRKKLMKDSLSLAAMLRRFTREK 275

  Fly   283 VIVTGKSKPSSSSLTSGKKPPTKPITTSSSSNSPRPSTVEISDTEDGQDPIQTQPSSQLQSLPQS 347
            ..:..||..|:..|.   :.|..|..||:::.|...|..:||     .||
Zfish   276 EEIRKKSPVSAVKLV---RAPPNPAVTSAAAPSDDLSMADIS-----ADP--------------- 317

  Fly   348 QAQAQALKKVVKTTTVKDMLKAKRDSFLKSQSGTAAVKGVGNGELKCVSTDVSSSDSSDMESEHG 412
                 |:..::...|..|||:...                  |:|.....| |...||..:||:|
Zfish   318 -----AMMSLLGGATENDMLQELM------------------GDLDFGLLD-SPQPSSPGQSENG 358

  Fly   413 RADRQAGQHGKDGQENLRTADTLLPTTLDADIVTAVNSFKEAVKSRDMCGKK--FNLDVK--LSP 473
            :|. ..|:..|.|.  :......||.:|.|.::..:...:.|.:..||.|:|  |.||:.  |..
Zfish   359 KAG-ATGRVQKSGM--MPMPPPPLPNSLPAPLLKRIEDLRAASRLFDMEGRKKFFTLDMNNILLD 420

  Fly   474 LLLRVYEAVLCTDRNERNMVFSHIEYQLQLPKYYMLRKGKQVRAKEEKRKSTIMLEKLRRAVAVV 538
            :.|:|.|..:..    |..|::|:|..:...|..:|::.|::....:..:....|.||:.||..|
Zfish   421 IELQVQEQPVPI----RAAVYTHLEAFVPCNKEALLKRLKKLSLNIQDDRLRTPLLKLKLAVCSV 481

  Fly   539 MPKAVANY---------ETELRTFAEQAAADVNSELPPKM---PRKKFQWTSELRHLLYDVYQAR 591
            ||:.:|.|         :.:...|....:.:.:.|.|.|.   |||||.|..:||.||.::.:.:
Zfish   482 MPEQIARYNMDCMAKVAKQQTEDFDRNGSEEEDDEKPGKRVMGPRKKFVWDDKLRTLLCNLVRVK 546

  Fly   592 WTSYAFLAKRKESLEEFINWYLKEKVVELWPPGWMRLDELQREITRYKNAKLKA----------- 645
            .:.|...|:...|.|:::..:::.:|..|||.|||:...|.:| :|..:..|.|
Zfish   547 LSCYELEAQSSLSPEDYLKVFMETEVKPLWPKGWMQARMLIKE-SRLAHNHLTANTVKKRVLPTP 610

  Fly   646 KEKPKAPPASASPKPVGVVSAPEQMPPASSYLK---AVEDPRSRGNSDTDSATSASSNSLKRKL- 706
            |.|||...:....:|...|..|.|.|...:..:   :..:|....:|..|...:.|.:|:...|
Zfish   611 KAKPKPQDSGVLQRPPVSVDTPSQTPSTPAIPRPQPSPPEPICLSDSLDDDLIAPSLDSISHALA 675

  Fly   707 ------KEMPKQTSKP---PKKKVAKQVPLQPQLTPHPQFQLAPAATAAVSIPAIS-----NNNN 757
                  |::.:..|.|   |.|....|...:...||.|....:..::::.|:..:|     ...:
Zfish   676 MLSSAAKDLVQSDSLPSSDPPKPAPPQQAKKSTNTPPPPPSPSILSSSSPSVKGVSVLSQVQRPS 740

  Fly   758 HLPHLDTLLSMPS----------TSAQAAALNAAAVAAASTVLDL----------ASPSRKIDLN 802
            .:|.....::.|:          ....|:.|:|.......||:.|          |||..:...|
Zfish   741 VIPTQRPTVAQPTKIGVSPAKPRPPPTASPLHAPQKITNKTVVTLPAGLIKSSNSASPQPRALPN 805

  Fly   803 TSNNFYNLITAASLAASGNPSPHSG---DGQAKVIVGARPSPHVINLDDYQCTSDILQTSKQLAA 864
            .|:......||.......:.:|..|   ..||.:    ..|||              ..|..:..
Zfish   806 ASSVINVKPTAPFHVTKNHEAPKPGFITPMQATI----TKSPH--------------NPSSNIIK 852

  Fly   865 TTTVITAISKAAQTTSVARESSSESDGVE---IVGVFPASKPQKKVQSKPKNKTQNRGRSSLGAV 926
            .|...:.:|:.....|:.:.::|:|.|..   :.|.:.|...|       |:.:|....|||
Zfish   853 LTPTASPVSRPTALPSMHQHTASKSAGFHPGYVAGGYSAPTAQ-------KSSSQGNSVSSL--- 907

  Fly   927 GQVNGSLGYSANNMYIYNSPRTLGPVYDLTDPHIMKTMSNLKEMEKQFIQAAFSPN-----SVKG 986
                 |:..||......:||.|  ||........::.:....:..|.....:.:.:     .|..
Zfish   908 -----SVQSSAVKQLPVSSPPT--PVATANHSQRLRPVGGANQGVKTITSVSTATSVSPLAQVSS 965

  Fly   987 ASGGMGSSAPSTPTRQXHSGSAAQQPLPAAVTAFYNQEAMAAAIVLSTMSHASPRYDLLANGSVS 1051
            :|..:||:||:.|......|......||.......|    ..:.|:||.|         ::||.|
Zfish   966 SSALLGSAAPALPLGFGMLGGLVPVSLPFQFPNLLN----LPSSVVSTAS---------SSGSSS 1017

  Fly  1052 MSAAQVGASANTL------PQVFVKPSLP------QPSAGGDVVTTT 1086
            .||:....|.|.|      ||..:.|.|.      ..:.|||:...|
Zfish  1018 ASASGFSLSPNVLKNLMSGPQAALPPHLQLAFPDVNQAQGGDLKRKT 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yem	NP_001263054.1	HUN	129..178	CDD:285888	28/48 (58%)
yem	NP_001263054.1	UBN_AB	443..633	CDD:290782	55/205 (27%)
ubn2b	NP_001098410.1	HUN	140..189	CDD:285888	28/48 (58%)
ubn2b	NP_001098410.1	UBN_AB	389..588	CDD:290782	55/202 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	80	1.000	Domainoid score	I8531
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I4079
OMA	1	1.010	-	-		QHG47800
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002638
OrthoInspector	1	1.000	-	-		otm25217
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21669
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4833
SonicParanoid	1	1.000	-	-		X2355
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.190