DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yem and UBN2

DIOPT Version :9

Sequence 1:	NP_001263054.1	Gene:	yem / 43439	FlyBaseID:	FBgn0005596	Length:	1101	Species:	Drosophila melanogaster
Sequence 2:	NP_775840.3	Gene:	UBN2 / 254048	HGNCID:	21931	Length:	1347	Species:	Homo sapiens

Alignment Length:	1168	Identity:	266/1168 - (22%)
Similarity:	444/1168 - (38%)	Gaps:	294/1168 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LEPDAASAAPDNSSKPTTKTAKCIRIKLDLFETDSNKYPEFNYSRLLYLEKKKTKKLKQVSTTNG 94
            |:|.....:...:.:|.....:.:|::|.|.:.......||:|..||...:::.|.:.
Human   104 LQPPPPRESASRAEQPPRPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKLIH------- 161

  Fly    95 SASTDPFADND---DDVARIVKELEAKYGNSYATGRGKSKKDDYRDIGMGYDESDSFIDNTEAYD 156
              :.|||.|..   .:|..:.|:.|.|||......| |.:..|..|||.||||:|.||||:||||
Human   162 --TEDPFNDEHQERQEVEMLAKKFEMKYGGKPRKHR-KDRLQDLIDIGFGYDETDPFIDNSEAYD 223

  Fly   157 EIIPEEAETLEGGFYINCGALEFKNLTKKSYTTRTDAIIKMPERSRKRMVSSSSESSSSSSGDDD 221
            |::|....|..||||||.|.|:|:..:
Human   224 ELVPASLTTKYGGFYINTGTLQFRQAS-------------------------------------- 250

  Fly   222 ENDDGNNEEDDESDSEDDSEENDESDSEDDSESESLEDEDSAATAKSSSK-------------YK 273
                 :.||||.:|::...........|||.|.:..:.::.....|...|             :|
Human   251 -----DTEEDDITDNQKHKPPKVPKIKEDDIEMKKRKRKEEGEKEKKPRKKVPKQLGVVALNSHK 310

  Fly   274 DNHQAKRAK-----VIVTGKSKPSSSSLTSGKKPPTKPITTSSSS-NSPRPSTVEISDTEDGQDP 332
            ...:.||.|     ..:..|.:....:|.....|.. |:|.|:.| |.|..:...:     |.|.
Human   311 SEKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKV-PVTLSTPSLNKPPCAAAAL-----GNDV 369

  Fly   333 IQTQPSSQLQSLPQSQAQAQALKKVVKTTTVKDMLKAKRDSFLKSQSGTAAVKGVGNGELKCVST 397
            .....||....||           :..:|...::.          |....|::.:.:.:...:..
Human   370 PDLNLSSGDPDLP-----------IFVSTNEHELF----------QEAENALEMLDDFDFDRLLD 413

  Fly   398 DVSSSDSSDMESEHGRADRQAGQHGKDGQENLRTADTL------LPTTLDADIVTAVNSFKEAVK 456
              ::||.|.: ||.|      |::|...|... |:..:      ||..|...:...:...:.|.|
Human   414 --AASDGSPL-SESG------GENGTTTQPTY-TSQVMPKVVPTLPEGLPVLLEKRIEDLRVAAK 468

  Fly   457 SRDMCGKK--FNLDV------------KLSPLLLRVYEAVLCTDRNERNMVFSHIEYQLQLPKYY 507
            ..|..|:|  |..|:            :|.|::              |:.|:||:|..:...|..
Human   469 LFDEEGRKKFFTQDMNNILLDIELQLQELGPVI--------------RSGVYSHLEAFVPCNKET 519

  Fly   508 MLRKGKQVRAKEEKRKSTIMLEKLRRAVAVVMPKAVANYETELRTFAEQAAADV----------- 561
            ::::.|::....:..:....|:||:.||:.|||:.:..|:.:.:..::...|.:
Human   520 LVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQTDEEREKNGS 584

  Fly   562 ---NSELPPKM---PRKKFQWTSELRHLLYDVYQARWTSYAFLAKRKESLEEFINWYLKEKVVEL 620
               :.|.|.|.   |||||.|...:|.||.::.:.:...|.....:.:|.|:::..:::.:|..|
Human   585 EEDDDEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPL 649

  Fly   621 WPPGWMRLDELQREITRYKNAKLKAKEKPKAPPASASPKP----VGVVSAP-------------- 667
            ||.|||:...|.:|.....|....|..|.|..||   |||    |.|.:.|
Human   650 WPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPA---PKPKVKEVMVKTLPLHSFPTMLKECSPK 711

  Fly   668 -EQMPPASSYLKAVEDPRSRGNSDTDSATSASSNSLKRKLKEMPKQTSKPPKKKVAKQVPLQPQL 731
             :|..| :|.:.:|..|.:   |.:.:|.:|:|:|            |.|.::.:.....|...|
Human   712 KDQKTP-TSLVASVSGPPT---SSSTAAIAAASSS------------SAPAQETICLDDSLDEDL 760

  Fly   732 TPH-PQFQLAPAATAAVSIPAISNNNNHLPHLDTLLSMPSTSAQAAALNAAAVAAASTVLDLASP 795
            :.| |...|...|.|.:      ||.|..|.:.:.:|||:|..: ..|....:|:..:.|.||:|
Human   761 SFHSPSLDLVSEALAVI------NNGNKGPPVGSRISMPTTKPR-PGLREEKLASIMSKLPLATP 818

  Fly   796 SRKIDLNTSNNFYNLITAASLAASGNPSP-------HSGDGQAKVIVGARPSPHVINLDDY--QC 851
             :|:|...:.:..:||     |....|.|       |:|.... :|.|:......::|:..  :.
Human   819 -KKLDSTQTTHSSSLI-----AGHTGPVPKKPQDLAHTGISSG-LIAGSSIQNPKVSLEPLPARL 876

  Fly   852 TSDILQTSKQLAATTTVITAISKAAQT----------TSVARESSS--------ESDGVEIVGVF 898
            ....||.|.|:..:::..|.:|.::|.          ||.|:::||        :...|:...|.
Human   877 LQQGLQRSSQIHTSSSSQTHVSSSSQAQIAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVS 941

  Fly   899 PASKPQKKVQSKPKNKTQNRGRSSLGAVGQVNGSLGYSANNMYIYNSPRTL----------GPVY 953
            |......|.|:.|..|..|..:.|      .:.||..:::...:|..|.:.          .|:.
Human   942 PLQATISKSQTNPVVKLSNNPQLS------CSSSLIKTSDKPLMYRLPLSTPSPGNGSQGSHPLV 1000

  Fly   954 DLTDPHIMKTMSN--LKEMEKQFIQAAF-SPNSVKGASGGMGSSAPSTPTRQXHSGSAAQQPLPA 1015
            ..|.|. ..|.||  .|.|..|.....| ||.|:..:.....|..|:|          :.:|||
Human  1001 SRTVPS-TTTSSNYLAKAMVSQISTQGFKSPFSMAASPKLAASPKPAT----------SPKPLP- 1053

  Fly  1016 AVTAFYNQEAMAAAIVLSTMSHASPRYDLLANGSVSMSAAQVGASANTLPQVFVKPSLPQPSA 1078
                             |....|||:..|.|..|||   .::.:.:|..|:..|.||...|:|
Human  1054 -----------------SPKPSASPKPSLSAKPSVS---TKLISKSNPTPKPTVSPSSSSPNA 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yem	NP_001263054.1	HUN	129..178	CDD:285888	28/48 (58%)
yem	NP_001263054.1	UBN_AB	443..633	CDD:290782	49/220 (22%)
UBN2	NP_775840.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..134		5/29 (17%)
		HUN	196..245	CDD:285888	28/48 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..301		11/93 (12%)
		UBN_AB	456..662	CDD:290782	49/219 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..597		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..740		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..849		10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..913		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	981..1006		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1035..1218		22/93 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9639
eggNOG	1	0.900	-	-		E1_KOG4786
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4175
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002638
OrthoInspector	1	1.000	-	-		otm41639
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21669
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2355
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	9.010