DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg14 and ATG14

DIOPT Version :9

Sequence 1:	NP_651669.1	Gene:	Atg14 / 43438	FlyBaseID:	FBgn0039636	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_055739.2	Gene:	ATG14 / 22863	HGNCID:	19962	Length:	492	Species:	Homo sapiens

Alignment Length:	471	Identity:	132/471 - (28%)
Similarity:	223/471 - (47%)	Gaps:	62/471 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 RCPLCHSCSASRFHCRNCVRNGNITHSQAERPESLTEKQQRYINLQAGLKTFSTR-YERLIGQHR 132
            |||||:: :..|..|..||::|:..:......|...:|::|...|::..:.|... .:.:.|:..
Human    42 RCPLCNT-TRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSRLKSKQEEFQKEVLKAMEGKWI 105

  Fly   133 SNEDRLMAIKAKRKQLELLQQLISG------TGQRLRVLGERRDEL---RRANAEKRKNLPKYPD 188
            :::.|...:..|.:..:|.|.:..|      ..:.|....|:..:|   .:.:.||::.:.::..
Human   106 TDQLRWKIMSCKMRIEQLKQTICKGNEEMEKNSEGLLKTKEKNQKLYSRAQRHQEKKEKIQRHNR 170

  Fly   189 KV-KMLENYVLD---RVEKIEKLRETHLGLLDSIKQAARRSIQQLVTYVFPIAEVV--LKEEQQR 247
            |: .::|...:|   ..|::..||.:|              |.:|.:.:|||.||.  :::....
Human   171 KLGDLVEKKTIDLRSHYERLANLRRSH--------------ILELTSVIFPIEEVKTGVRDPADV 221

  Fly   248 RASVERTEEAETIAALADAKNTSYIRGKWVFHGSGISEVQYRIVGP--SLPANGDYTAYLDWLAD 310
            .:..:....:.|::.||:|:.|:|:.|:||..... .:....|.||  |||.||||:||..|:.:
Human   222 SSESDSAMTSSTVSKLAEARRTTYLSGRWVCDDHN-GDTSISITGPWISLPNNGDYSAYYSWVEE 285

  Fly   311 NKDDVPKATANEITPSRFEAYRIVGALTYTAQLTQLLSFYLNVRLPHKIAYGDFCRKLLNEEQFR 375
            .     |.|..........||.|..||.|..||..:||..|:|.||.|:...:||.:.|::::|.
Human   286 K-----KTTQGPDMEQSNPAYTISAALCYATQLVNILSHILDVNLPKKLCNSEFCGENLSKQKFT 345

  Fly   376 RKISRLNSNIMYLAYTQQVKLRALIEQHTLENLLAILDLERSDLGRYGHLDVNNAPLMKSVDSLL 440
            |.:.:||:||:||.::|.|.|..|...|||.||:.::......|||.|..:| .|.|.:|::.:.
Human   346 RAVKKLNANILYLCFSQHVNLDQLQPLHTLRNLMYLVSPSSEHLGRSGPFEV-RADLEESMEFVD 409

  Fly   441 IGI-----ETATESESEDENSLRMDWEAVPSLTPQPELAD-PNLMPAANQ-QSTIA--------- 489
            .|:     |:..|..|::|..|..|||.:||    |...| |:.....:| |||.|
Human   410 PGVAGESDESGDERVSDEETDLGTDWENLPS----PRFCDIPSQSVEVSQSQSTQASPPIASSSA 470

  Fly   490 --FVRMAATSVLRWIK 503
              .:..||.||..|.|
Human   471 GGMISSAAASVTSWFK 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg14	NP_651669.1	Atg14	70..412	CDD:287195	98/359 (27%)
Atg14	NP_651669.1	LON	<154..266	CDD:271862	23/126 (18%)
ATG14	NP_055739.2	Atg14	43..388	CDD:313424	98/365 (27%)
		Cysteine repeats	43..58		6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..473		19/66 (29%)
		BATS. /evidence=ECO:0000250	413..492		24/78 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141210
Domainoid	1	1.000	142	1.000	Domainoid score	I4684
eggNOG	1	0.900	-	-		E1_KOG4398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45423
Inparanoid	1	1.050	169	1.000	Inparanoid score	I4148
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48579
OrthoDB	1	1.010	-	-		D1332122at2759
OrthoFinder	1	1.000	-	-		FOG0009842
OrthoInspector	1	1.000	-	-		oto89555
orthoMCL	1	0.900	-	-		OOG6_108178
Panther	1	1.100	-	-	LDO	PTHR13664
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5332
SonicParanoid	1	1.000	-	-		X7572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800