Protein Alignment Atg14 and ATG14

DIOPT Version :10

• Sequence 1: NP_651669.1
• Gene: Atg14 / 43438
• FlyBaseID: FBgn0039636
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_055739.2
• Gene: ATG14 / 22863
• HGNCID: 19962
• Length: 492
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 132/471 - (28%)
• Similarity: 223/471 - (47%)
• Gaps: 62/471 - (13%)

  Fly    69 RCPLCHSCSASRFHCRNCVRNGNITHSQAERPESLTEKQQRYINLQAGLKTFSTR-YERLIGQHR 132
            |||||:: :..|..|..||::|:..:......|...:|::|...|::..:.|... .:.:.|:..
Human    42 RCPLCNT-TRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSRLKSKQEEFQKEVLKAMEGKWI 105

  Fly   133 SNEDRLMAIKAKRKQLELLQQLISG------TGQRLRVLGERRDEL---RRANAEKRKNLPKYPD 188
            :::.|...:..|.:..:|.|.:..|      ..:.|....|:..:|   .:.:.||::.:.::..
Human   106 TDQLRWKIMSCKMRIEQLKQTICKGNEEMEKNSEGLLKTKEKNQKLYSRAQRHQEKKEKIQRHNR 170

  Fly   189 KV-KMLENYVLD---RVEKIEKLRETHLGLLDSIKQAARRSIQQLVTYVFPIAEVV--LKEEQQR 247
            |: .::|...:|   ..|::..||.:|              |.:|.:.:|||.||.  :::....
Human   171 KLGDLVEKKTIDLRSHYERLANLRRSH--------------ILELTSVIFPIEEVKTGVRDPADV 221

  Fly   248 RASVERTEEAETIAALADAKNTSYIRGKWVFHGSGISEVQYRIVGP--SLPANGDYTAYLDWLAD 310
            .:..:....:.|::.||:|:.|:|:.|:||..... .:....|.||  |||.||||:||..|:.:
Human   222 SSESDSAMTSSTVSKLAEARRTTYLSGRWVCDDHN-GDTSISITGPWISLPNNGDYSAYYSWVEE 285

  Fly   311 NKDDVPKATANEITPSRFEAYRIVGALTYTAQLTQLLSFYLNVRLPHKIAYGDFCRKLLNEEQFR 375
            .     |.|..........||.|..||.|..||..:||..|:|.||.|:...:||.:.|::::|.
Human   286 K-----KTTQGPDMEQSNPAYTISAALCYATQLVNILSHILDVNLPKKLCNSEFCGENLSKQKFT 345

  Fly   376 RKISRLNSNIMYLAYTQQVKLRALIEQHTLENLLAILDLERSDLGRYGHLDVNNAPLMKSVDSLL 440
            |.:.:||:||:||.::|.|.|..|...|||.||:.::......|||.|..:| .|.|.:|::.:.
Human   346 RAVKKLNANILYLCFSQHVNLDQLQPLHTLRNLMYLVSPSSEHLGRSGPFEV-RADLEESMEFVD 409

  Fly   441 IGI-----ETATESESEDENSLRMDWEAVPSLTPQPELAD-PNLMPAANQ-QSTIA--------- 489
            .|:     |:..|..|::|..|..|||.:||    |...| |:.....:| |||.|
Human   410 PGVAGESDESGDERVSDEETDLGTDWENLPS----PRFCDIPSQSVEVSQSQSTQASPPIASSSA 470

  Fly   490 --FVRMAATSVLRWIK 503
              .:..||.||..|.|
Human   471 GGMISSAAASVTSWFK 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg14	NP_651669.1	ATG14	70..412	CDD:462986	98/359 (27%)
ATG14	NP_055739.2	ATG14	43..388	CDD:462986	98/365 (27%)
		Cysteine repeats	43..58		6/15 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..473		19/66 (29%)
		BATS. /evidence=ECO:0000250	413..492		24/78 (31%)