DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdhb and PDB1

DIOPT Version :9

Sequence 1:	NP_651668.1	Gene:	Pdhb / 43437	FlyBaseID:	FBgn0039635	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_009780.1	Gene:	PDB1 / 852522	SGDID:	S000000425	Length:	366	Species:	Saccharomyces cerevisiae

Alignment Length:	346	Identity:	207/346 - (59%)
Similarity:	261/346 - (75%)	Gaps:	9/346 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AASSAQRAFSTSQKALAAKQMTVRDALNSALDDELARDDRVFILGEEVAQYDGAYKVSRGLWKKY 73
            ||::|.|..||       |.||||:|||||:.:||.|||.||::|||||||:||||||:||..::
Yeast    26 AAAAALRFSST-------KTMTVREALNSAMAEELDRDDDVFLIGEEVAQYNGAYKVSKGLLDRF 83

  Fly    74 GDKRVIDTPITEMGFAGIAVGAAMAGLRPVCEFMTWNFSMQAIDHIINSAAKTFYMSAGAVNVPI 138
            |::||:||||||.||.|:|||||:.||:|:.|||::|||||||||::||||||.|||.|.....:
Yeast    84 GERRVVDTPITEYGFTGLAVGAALKGLKPIVEFMSFNFSMQAIDHVVNSAAKTHYMSGGTQKCQM 148

  Fly   139 VFRGPNGAASGVAAQHSQCFAAWYAHCPGLKVLSPYDAEDARGLLKSAIRDPDPVVFLENELVYG 203
            |||||||||.||.|||||.|:.||...||||||.||.|||||||||:|||||:|||||||||:||
Yeast   149 VFRGPNGAAVGVGAQHSQDFSPWYGSIPGLKVLVPYSAEDARGLLKAAIRDPNPVVFLENELLYG 213

  Fly   204 TAFPVADNVADKDFLVPIGKAKVMRPGKDITLVAHSKAVETSLLAAAELAKK-GIEAEVINLRSI 267
            .:|.:::.....:|.:|. |||:.|.|.||::|.:::.|:.||.||..|.|| |:.|||||||||
Yeast   214 ESFEISEEALSPEFTLPY-KAKIEREGTDISIVTYTRNVQFSLEAAEILQKKYGVSAEVINLRSI 277

  Fly   268 RPLDTATIFASVRKTHHLVTVENGWPQHGVGAEICARIMEDQTFFELDAPVWRCAGVDVPMPYAK 332
            |||||..|..:|:||:||:|||:.:|..||||||.|::||.:.|..||||:.|..|.|||.||||
Yeast   278 RPLDTEAIIKTVKKTNHLITVESTFPSFGVGAEIVAQVMESEAFDYLDAPIQRVTGADVPTPYAK 342

  Fly   333 TLEAHALPRVQDLVEATLKVL 353
            .||..|.|....:|:|..:||
Yeast   343 ELEDFAFPDTPTIVKAVKEVL 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdhb	NP_651668.1	PLN02683	2..352	CDD:215368	205/343 (60%)
		TPP_PYR_E1-PDHc-beta_like	33..199	CDD:132919	116/165 (70%)
		Transketolase_C	222..340	CDD:280875	67/118 (57%)
PDB1	NP_009780.1	PRK11892	<6..362	CDD:237011	205/343 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344171
Domainoid	1	1.000	260	1.000	Domainoid score	I312
eggNOG	1	0.900	-	-		E1_COG0022
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H712
Inparanoid	1	1.050	400	1.000	Inparanoid score	I314
Isobase	1	0.950	-	0	Normalized mean entropy	S229
OMA	1	1.010	-	-		QHG53958
OrthoFinder	1	1.000	-	-		FOG0002922
OrthoInspector	1	1.000	-	-		oto99170
orthoMCL	1	0.900	-	-		OOG6_101309
Panther	1	1.100	-	-	LDO	PTHR11624
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R864
SonicParanoid	1	1.000	-	-		X2740
TreeFam	1	0.960	-	-
	16	15.740