Protein Alignment Pdhb and Pdhb

DIOPT Version :10

• Sequence 1: NP_651668.1
• Gene: Pdhb / 43437
• FlyBaseID: FBgn0039635
• Length: 365
• Species: Drosophila melanogaster
• Sequence 2: NP_077183.1
• Gene: Pdhb / 68263
• MGIID: 1915513
• Length: 359
• Species: Mus musculus
• Alignment Length: 939
• Identity: 175/939 - (18%)
• Similarity: 313/939 - (33%)
• Gaps: 265/939 - (28%)

  Fly    28 LSGDSLIL---RDKPVNGPPREK---QLNFAGIVAPKLARRPTNGSSDGSRDQPYAWESREYLRQ 86
            :||||.:.   .|..:....|::   :...||:   :|.|.||                    :|
Mouse   726 VSGDSCVFVWRLDSQMTNSMRKRLAERKQQAGL---RLQRAPT--------------------KQ 767

  Fly    87 RLIGQEVWFYSEKPPNANREYGYVKLGKEPNAENIVE-------------SIVSEGLVT------ 132
            .:|.:|.  |...|.||........|..|.|.|:.:|             |:.|..|.|
Mouse   768 EVIRRET--YITVPCNALTHMEEDGLMAEVNPEDGLEDCRTPDRLDSTDASLDSVVLQTNGKMPM 830

  Fly   133 -VRR-------------DNVRQTPEHARLIELEDAARRARKGLWSDAPEGEHVRNIVWNIDNPKQ 183
             |||             :.|:..|:....::.:..|.|....:.|:.....|..:.|...:..::
Mouse   831 WVRRLGGEGEKDGTGAANRVQYQPQGRWAVQSDPLAIRTVLEMKSNQLPLSHTPSRVMGEEELEE 895

  Fly   184 FVDQHAGQLIKAIIEHVRDGSTVRAFLMPNPRVFQHVTLMMSGIRCPGFKLDAEGRPDNTTEVPY 248
            ....|...|...:.|.:.||.             :.....:.|:...||.....| |: ..:.|:
Mouse   896 DPRFHPQSLDSLLDEDLEDGE-------------EEEEEKICGVSSDGFSSSLHG-PE-FLQFPH 945

  Fly   249 ADEARFHVECRLLQREVKVRLESNSNTNFLGTILCPEGNIAESLLRNGF---AKCVEWSIPYVKE 310
            .:| .|:.|           |.|:..|   |.||.|..:.|.|.....|   |.|...:....:|
Mouse   946 GEE-NFNPE-----------LSSSEKT---GYILYPANSTALSTGEGEFDVKALCEGTAGDPDEE 995

  Fly   311 GIDRLRACEREAKAARLRLWKDYKPP--AALANT------KDKELVGTVMEVYNGDAVLVKVGTV 367
            .:....||..|:..:......|....  :.:::|      :|:|..||::..:     ...:|..
Mouse   996 ELSPDSACSAESPESHSDQPHDQDTDSLSQVSSTGSSGVEEDEEESGTLLRQH-----FDTLGVA 1055

  Fly   368 SKKVF---FSSIRPPRPKEDDGPRAKNSRPLYDIPYMFEAREFLRKKLIGKRVTCTLDYVAPARD 429
            :.:.|   .||::|........||...|            ..||.:.....|..|.   .|....
Mouse  1056 TNEKFNTDLSSLQPTTESNFLNPRLSIS------------TRFLSRFQSRFRAACR---PAACLS 1105

  Fly   430 NYPEKYCYTVRLDDQNIAEAMLE-RGLATVINYRQDDEQRSPEYDKLRAAQEQAIKGQKGMHAKK 493
            :.|::     ..|.|.:.:.|.: :.|:   |....:|:...|......:..|:.....|:.:.|
Mouse  1106 SIPDE-----STDSQTLDQTMEKPKHLS---NSGSVEEKEKTEITNKNQSTTQSTTSAPGVLSNK 1162

  Fly   494 QTPSHRINDLTTDHSRIKHHYL-PSWQRALRTEALVEFVASGSRLRLYCPKESCLVTFLLAGISC 557
            .|.    |......:|.:..|: |:    ..:.|.:....|...|.|...:|:.|..  |..:..
Mouse  1163 STS----NSCDASVTRSRQSYMGPT----ASSRAKINQSNSVESLNLCISEETPLNA--LPNVEH 1217

  Fly   558 RRS-----SRPAIGGAPAQEAEPYGDEALQFTREKVLQRDVSVKIETTDKQATSVIGWLFTDHN- 616
            .:.     |.|.:..||..::...|:.:.:          .|::::        :||     ||
Mouse  1218 SKENMIPPSSPVVSSAPLHQSPVLGNHSAR----------ASLRLD--------LIG-----HNR 1259

  Fly   617 VNLSVALVE--EGLAEVHFTAEKSDYYRVLRDAEARA--KAQRKNIWKDYVEKAAAEEEKDEIED 677
            .:||...::  .|..|.|.:..:.   .::...|.|:  |..||.|  ..:|::.|..::.....
Mouse  1260 ASLSPVSLKSRRGKVEHHDSPRRQ---ALVTPTEMRSLGKESRKQI--SNIEQSLAPSDRLSTGA 1319

  Fly   678 TPDVNTPVERKVKYESVVVTEVTPELQFYAQHTDQGAKLEELMTKLRQDFK------AMPPVTGS 736
            .....:|:.|:..      ..|..:||  :..:||.:....:...:.||.:      ::|..||.
Mouse  1320 GMFSRSPMVRQTS------DTVFEDLQ--SVRSDQTSVSSPMTNAVSQDNQDSADNNSIPEETGL 1376

  Fly   737 YAPKRG-DMCAAKFSEDNEWYRAKVEKVEKGGNVTILYIDYGNRETVPSTRLAMIPPTFISEKPF 800
            .|.... .||....:|  .|:     .:.|   .|.||           ::|..||
Mouse  1377 SAEALSVQMCKEMVNE--LWH-----TIHK---ATDLY-----------SKLCSIP--------- 1411

  Fly   801 AHLYVPALLLLPTDADDRAEAVKAFSQDV---LNRTLNMNVEYRISGTEYVTLTDPATKA--DIA 860
                         :..::.|.:|...|:|   :...||.....:         |.|:||:  .|:
Mouse  1412 -------------ELSEQQEQMKGVLQEVFVGVQSELNSICPQK---------TQPSTKSTRPIS 1454

  Fly   861 EDLIADGYLIADKNKKDRRLTKLIADYKD 889
            ||  :.|     :..:|.|...|:..|.:
Mouse  1455 ED--SPG-----RQLRDDRAVALLEKYSE 1476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdhb	NP_651668.1	PLN02683	2..352	CDD:215368	74/373 (20%)
Pdhb	NP_077183.1	PRK11892	<31..355	CDD:237011